HOME >> MEDICINE >> NEWS
BioNumerik Reports Preclinical Antitumor Data On Two Novel Supercomputer Engineered Anticancer Agents At 89th Annual AACR Conference

tives. These results also demonstrate the ability of BioNumerik's Karenitecins to bypass common drug resistance mechanisms (MDR, MRP & LRP) to which many other camptothecins appear to be susceptible. Because its compounds are lipophilic, BioNumerik believes its Karenitecins will have enhanced tissue penetration, drug delivery and bioavailability compared to water soluble camptothecins.

Camptothecins, described as Topoisomerase I inhibitors, represent some of the most active anticancer drugs in existence. Due to formulation problems, however, the great majority of camptothecins in development or on the market have been made water soluble to allow easier drug dissolution and administration. BioNumerik believes that this approach may limit the utility of these drugs and the Company has developed a new generation of proprietary highly lipophilic (fat loving) camptothecins, known as Karentitecins, that have been designed to overcome problems that exist with camptothecin and the current camptothecin derivatives.

Using its mechanism-based approach, BioNumerik used its Cray supercomputers to construct a detailed computational model involving human Topoisomerase I and DNA in order to understand and more precisely target the key interactions between camptothecin-Topo I/DNA. BioNumerik used this information to guide and complement the discovery and optimization of novel compounds for laboratory synthesis and preclinical testing.

In a presentation titled "BNP7787: Administration In Vivo Results in Increased Therapeutic Index and Toxicity Reduction of Platinum Drugs", BioNumerik also presented data on its proprietary agent BNP7787, a novel water soluble disulfide that was engineered to increase the therapeutic index of cisplatin and carboplatin, two widely used anticancer drugs.

Although platinum chemotherapy is widespread, formulations of cisplatin and carboplatin have a major risk of kidney toxicity (cisplatin), nausea and vomiting, bone marrow suppressio
'"/>

Contact: Neil Cohen
neil@noonanrusso.com
212-696-4455 x. 205
Noonan/Russo Communications
30-Mar-1998


Page: 1 2 3 4 5

Related medicine news :

1. BioNumerik Reports Data On Two Novel Supercomputer Engineered Anticancer Agents At 90th Annual Meeting Of The AACR
2. BioNumerik Reports The Supercomputer Supported Discovery Of New, Non-Toxic Chemotherapy Protecting Agent
3. Abgenix Reports Positive Survival Data From A Phase II Trial Of ABX-CBL In Graft Versus Host Disease
4. Melanoma Patients Sentinel Lymph Nodes (SLNS) Play A Strong Role In Disease Prognosis, UCSF Study Reports
5. Irritable Bowel Syndrome The Focus Of Three UNC-CH Reports At Digestive Diseases Conference
6. UCSF-Harvard Team Reports Encouraging Results In Drug Study Of Mice With Cancer
7. Bone Marrow With Heart And Lung Transplants Reduces Rejection Of Transplanted Organs, Reports University Of Pittsburgh
8. Bone Marrow With Organ Transplants Reduces Rejection Of Transplanted Organs, Reports University Of Pittsburgh
9. Changes In Levels Of LDLc From Pre- To Post-Menopausal Years Not Valuable Indicator Of Heart Disease, Reports University Of Pittsburgh Researcher
10. Medicare Policy Contradicts Preferred Treatment For Precancerous Skin Conditions, Westwood Squibb Center For Dermatology Research Reports
11. International Study Finds Statins Raise Good Cholesterol, Wake Forest Physician Reports

Post Your Comments:
(Date:3/5/2015)... JACKSON, MS (PRWEB) March 05, 2015 ... “The Basics and Beyond,” leaders in addiction treatment met ... and updates in best clinical practices. Among the numerous ... M.D. , who will address the role that pain ... epidemic and new evidence-based treatment options. , "It is ...
(Date:3/5/2015)... (PRWEB) March 05, 2015 Califia ... leader in the natural products coffee drinks category[1], today ... Products Expo West in Anaheim, Calif. Concentrated Cold ... concept, Califia Café, which democratizes the next wave of ... ingredients they need to become their own baristas. ...
(Date:3/5/2015)... March 05, 2015 Supply & Demand ... listing of “Pros to Know” in the supply chain ... members of MEBC’s leadership team were included on this ... and received this award due to their hard work, ... methods for meeting and resolving client needs and challenges. ...
(Date:3/5/2015)... March 05, 2015 INTEGRATED Healthcare ... organizations to participate in its 2015 Children’s Hospitals ... executive and director-level positions, and the survey results ... year’s report featured data on 60 executive and ... healthcare organizations and 7 subsidiary children’s hospitals. Additionally, ...
(Date:3/5/2015)... Today, Earth Source Organics (ESO) ... pollution-free electricity through a partnership with national Clean ... Arcadia Power Clean Energy Partner, ESO now meets ... requirements, joining national brands such as Whole Foods, ... Earth Source Organics joins a growing community of ...
Breaking Medicine News(10 mins):Health News:National Addiction Treatment Expert William S. “Bill” Jacobs, Md Speaks At Prestigious 7th Annual Mississippi Addiction Conference 2Health News:National Addiction Treatment Expert William S. “Bill” Jacobs, Md Speaks At Prestigious 7th Annual Mississippi Addiction Conference 3Health News:Califia Farms Personalizes At-Home Coffee Experience with the Launch of Concentrated Cold Brew Coffee 2Health News:Califia Farms Personalizes At-Home Coffee Experience with the Launch of Concentrated Cold Brew Coffee 3Health News:Califia Farms Personalizes At-Home Coffee Experience with the Launch of Concentrated Cold Brew Coffee 4Health News:MEBC Leaders Awarded Supply Demand Chain Executive Pros to Know Title For 2015 2Health News:Participation Is Now Open For INTEGRATED Healthcare Strategies 2015 Children’s Hospitals Executive Compensation Survey 2Health News:Earth Source Organics to Run on Clean Energy from Arcadia Power 2
(Date:3/5/2015)... -- AMRI (NASDAQ: AMRI ) announced today that ... of VP of International Sales, effective immediately. He reports ... Global Sales and Marketing. In this ... in an effort to increase worldwide customer value and ... will drive strategy for sales and marketing efforts across ...
(Date:3/5/2015)... WASHINGTON , March 5, 2015 ... applauds the Food and Drug Administration,s (FDA) approval ... (nivolumab). Opdivo and other immunotherapy treatments add another ... by harnessing the power of a patient,s own ... drug has been approved specifically for patients with ...
(Date:3/5/2015)... 05, 2015 Research and Markets ... the "Global Pharma US & EU Outlook ... Major Role In Shaping Up Business for Large ... Strategy Diversification Divested: Productivity measurements, ... position- Will accelerate Next wave of targeted acquisition ...
Breaking Medicine Technology:AMRI Hires VP of International Sales 2LUNGevity Foundation Applauds FDA Approval of Immunotherapy Drug Opdivo 2LUNGevity Foundation Applauds FDA Approval of Immunotherapy Drug Opdivo 3Global Pharma US & EU Outlook 2015: First -In-Class Innovations and Cost Optimization Plays Major Role In Shaping Up Business for Large Cap Pharmaceutical Companies 2Global Pharma US & EU Outlook 2015: First -In-Class Innovations and Cost Optimization Plays Major Role In Shaping Up Business for Large Cap Pharmaceutical Companies 3
Cached News: