HOME >> MEDICINE >> NEWS
BioNumerik Reports The Supercomputer Supported Discovery Of New, Non-Toxic Chemotherapy Protecting Agent

San Antonio, TX - October 12, 1998 -- BioNumerik Pharmaceuticals, Inc. today announced a key scientific publication in the October issue of the journal Seminars in Oncology which describes the discovery and mechanism of action of a new non-toxic, second-generation platinum protecting agent, known as BNP7787, which appears to substantially reduce the toxicity of platinum-type anticancer drugs, such as cisplatin and carboplatin.

Cisplatin and carboplatin are widely used in the treatment of a variety of common cancers including small cell and non-small cell lung cancer, ovarian, head and neck, and bladder cancer and many other tumors. However, the administration of cisplatin and carboplatin frequently results in clinically important toxicities, including kidney toxicity, vomiting, and bone marrow toxicity, that pose certain risks and adversely affect the quality of life of patients. BioNumerik investigators began their discovery efforts in this area with the idea that if it were possible to safely increase the total dose or the dose frequency of platinum drugs, this would lead to an increase in tumor response rates and could result in a substantial patient benefit. To date, several platinum protecting agents have been developed by others, but all have suffered from the problem of trading a reduction in platinum-associated drug toxicities for newly-introduced toxicities of their own.

The Seminars in Oncology paper, titled "Modulation of Platinum-Induced Toxicities and Therapeutic Index: Mechanistic Insights and First- and Second-Generation Protecting Agents," authored by Dr. Frederick H. Hausheer, et al., describes new information regarding the chemical basis for the antitumor and toxicologic effects associated with the administration of platinum-type drugs. BioNumerik's chemical, pharmacological and toxicological data, combined with that of other studies, suggest that nearly all of the major clin
'"/>

Contact: Neil Cohen
neil@noonanrusso.com
415-677-4455
Noonan/Russo Communications
13-Oct-1998


Page: 1 2 3

Related medicine news :

1. BioNumerik Reports Data On Two Novel Supercomputer Engineered Anticancer Agents At 90th Annual Meeting Of The AACR
2. BioNumerik Reports Preclinical Antitumor Data On Two Novel Supercomputer Engineered Anticancer Agents At 89th Annual AACR Conference
3. Abgenix Reports Positive Survival Data From A Phase II Trial Of ABX-CBL In Graft Versus Host Disease
4. Melanoma Patients Sentinel Lymph Nodes (SLNS) Play A Strong Role In Disease Prognosis, UCSF Study Reports
5. Irritable Bowel Syndrome The Focus Of Three UNC-CH Reports At Digestive Diseases Conference
6. UCSF-Harvard Team Reports Encouraging Results In Drug Study Of Mice With Cancer
7. Bone Marrow With Heart And Lung Transplants Reduces Rejection Of Transplanted Organs, Reports University Of Pittsburgh
8. Bone Marrow With Organ Transplants Reduces Rejection Of Transplanted Organs, Reports University Of Pittsburgh
9. Changes In Levels Of LDLc From Pre- To Post-Menopausal Years Not Valuable Indicator Of Heart Disease, Reports University Of Pittsburgh Researcher
10. Medicare Policy Contradicts Preferred Treatment For Precancerous Skin Conditions, Westwood Squibb Center For Dermatology Research Reports
11. International Study Finds Statins Raise Good Cholesterol, Wake Forest Physician Reports

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/12/2019)... ... November 12, 2019 , ... The quality of study ... cycle times, extended contract negotiations and 80 percent of organizations still using spreadsheets ... that’s ripe for improvement. Following an overview of the challenges facing trial sponsors, ...
(Date:11/12/2019)... Calif. (PRWEB) , ... November 12, 2019 , ... ... certification, licensing, and compliance management, today announced the release of new features for ... of Certemy’s platform interface and emails to match their physical brand attributes. Customizable ...
(Date:11/11/2019)... ... November 11, 2019 , ... As Americans celebrate Veterans Day and honor ... important to remember that they also deserve recognition and compassionate care when dealing with ... Heart Hospice is demonstrating its commitment to providing specialized care for Veterans who ...
(Date:11/11/2019)... , ... November 11, 2019 , ... ... the shipment of two (2) Gruenberg Depyrogenation Sterilizers to the Pharmaceutical ... sterilizers have maximum temperature ratings of 280°C with work chamber dimensions of 36” ...
(Date:11/11/2019)... ... November 11, 2019 , ... ... care and occupational medicine, is expanding its long-term partnership with 919 Marketing ... franchise candidates. With more than 200 locations across the country, American Family Care ...
Breaking Medicine News(10 mins):
(Date:11/12/2019)... ... November 12, 2019 , ... MedMark Treatment Centers, a BayMark ... in the Cincinnati, OH suburb of Milford. MedMark Milford provides proven treatment for ... located at 749C State Route 28 in Milford, is now accepting patients. ...
(Date:11/11/2019)... ... November 11, 2019 , ... Windsor Care ... and Ethics Week. The Society of Corporate Compliance and Ethics & Health ... this year from November 3 through 9, 2019. This is the third year ...
(Date:11/11/2019)... CHARLOTTE, N.C., and GREENSBORO, N.C. (PRWEB) , ... November 11, 2019 ... ... that delivers value-based care to adults on Medicare, has opened two new centers in ... healthcare as it should be, Oak Street Health offers an entirely different model of ...
Breaking Medicine Technology:
Cached News: