HOME >> MEDICINE >> NEWS
BioNumerik Reports The Supercomputer Supported Discovery Of New, Non-Toxic Chemotherapy Protecting Agent

San Antonio, TX - October 12, 1998 -- BioNumerik Pharmaceuticals, Inc. today announced a key scientific publication in the October issue of the journal Seminars in Oncology which describes the discovery and mechanism of action of a new non-toxic, second-generation platinum protecting agent, known as BNP7787, which appears to substantially reduce the toxicity of platinum-type anticancer drugs, such as cisplatin and carboplatin.

Cisplatin and carboplatin are widely used in the treatment of a variety of common cancers including small cell and non-small cell lung cancer, ovarian, head and neck, and bladder cancer and many other tumors. However, the administration of cisplatin and carboplatin frequently results in clinically important toxicities, including kidney toxicity, vomiting, and bone marrow toxicity, that pose certain risks and adversely affect the quality of life of patients. BioNumerik investigators began their discovery efforts in this area with the idea that if it were possible to safely increase the total dose or the dose frequency of platinum drugs, this would lead to an increase in tumor response rates and could result in a substantial patient benefit. To date, several platinum protecting agents have been developed by others, but all have suffered from the problem of trading a reduction in platinum-associated drug toxicities for newly-introduced toxicities of their own.

The Seminars in Oncology paper, titled "Modulation of Platinum-Induced Toxicities and Therapeutic Index: Mechanistic Insights and First- and Second-Generation Protecting Agents," authored by Dr. Frederick H. Hausheer, et al., describes new information regarding the chemical basis for the antitumor and toxicologic effects associated with the administration of platinum-type drugs. BioNumerik's chemical, pharmacological and toxicological data, combined with that of other studies, suggest that nearly all of the major clin
'"/>

Contact: Neil Cohen
neil@noonanrusso.com
415-677-4455
Noonan/Russo Communications
13-Oct-1998


Page: 1 2 3

Related medicine news :

1. BioNumerik Reports Data On Two Novel Supercomputer Engineered Anticancer Agents At 90th Annual Meeting Of The AACR
2. BioNumerik Reports Preclinical Antitumor Data On Two Novel Supercomputer Engineered Anticancer Agents At 89th Annual AACR Conference
3. Abgenix Reports Positive Survival Data From A Phase II Trial Of ABX-CBL In Graft Versus Host Disease
4. Melanoma Patients Sentinel Lymph Nodes (SLNS) Play A Strong Role In Disease Prognosis, UCSF Study Reports
5. Irritable Bowel Syndrome The Focus Of Three UNC-CH Reports At Digestive Diseases Conference
6. UCSF-Harvard Team Reports Encouraging Results In Drug Study Of Mice With Cancer
7. Bone Marrow With Heart And Lung Transplants Reduces Rejection Of Transplanted Organs, Reports University Of Pittsburgh
8. Bone Marrow With Organ Transplants Reduces Rejection Of Transplanted Organs, Reports University Of Pittsburgh
9. Changes In Levels Of LDLc From Pre- To Post-Menopausal Years Not Valuable Indicator Of Heart Disease, Reports University Of Pittsburgh Researcher
10. Medicare Policy Contradicts Preferred Treatment For Precancerous Skin Conditions, Westwood Squibb Center For Dermatology Research Reports
11. International Study Finds Statins Raise Good Cholesterol, Wake Forest Physician Reports

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/14/2019)... ... September 14, 2019 , ... GreenTheVoteOk , one of the ... again tried to bring the most relevant and important developments in the fast-changing world ... increasingly large number of people across the world suffering from different difficult-to-treat ailments, people ...
(Date:9/11/2019)... Pa. (PRWEB) , ... September 12, 2019 , ... “Heart ... living with diagnosed coronary artery disease as he hopes to prevent anyone from having ... creation of published author John Saltwick, a writer who was diagnosed with coronary artery ...
(Date:9/11/2019)... ... 11, 2019 , ... A September 2 article on CBS News ... significantly less likely to suffer heart attacks, strokes, kidney failure, and heart disease versus ... weight loss surgery specialists Dr. Feiz and Associates says the study adds further evidence ...
(Date:9/11/2019)... (PRWEB) , ... September 11, 2019 , ... ... will be held September 11-14 in Minneapolis at the Mall of America Radisson ... LaPrade, will be faculty members for the high-profile, knee-focused conference, which brings together ...
(Date:9/11/2019)... DANBURY, Conn. (PRWEB) , ... September 11, 2019 , ... ... helps couples and individuals grow their family, will host a free informational event that ... and a food truck meal voucher for the first fifty registrants. The event, “What’s ...
Breaking Medicine News(10 mins):
(Date:9/14/2019)... BOSTON (PRWEB) , ... September 13, 2019 , ... ... provider of teledentistry services for employers, became the first commercial teledentistry practice in ... an award-winning startup with other hub entrepreneurs, company leaders, innovators and industry experts ...
(Date:9/14/2019)... ... ... The Allergenic Products Advisory Committee of the Food and Drug Administration (FDA) ... approval of a standardized oral immunotherapy (OIT) product for peanut allergy. The brand name ... The FDA would require a Risk Evaluation and Mitigation Strategy (REMS) to be developed ...
(Date:9/12/2019)... ... ... Stratosphere Networks will sponsor GRIN2B Foundation’s first cocktail reception fundraiser, Gather ... Kitchen and Social House in Evanston from 6 p.m. to 9 p.m. , Proceeds ... gene on the short arm of the 12th chromosome and is part of a ...
Breaking Medicine Technology:
Cached News: