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BioNumerik Reports The Supercomputer Supported Discovery Of New, Non-Toxic Chemotherapy Protecting Agent

the Netherlands.

Richard L. Schilsky, M.D., Director of the University of Chicago Cancer Research Center and Principal Investigator for the University of Chicago BNP7787 Phase I trial indicated, "We are extremely pleased to have the opportunity to conduct Phase I trials on this exciting new drug. BNP7787 has great potential to increase the safety of platinum therapy and to provide meaningful increases in tumor response rates."

In commenting on the data, Dr. Frederick H. Hausheer, BioNumerik's Chairman & Chief Executive Officer stated: "This information represents an important new development in understanding the chemical mechanisms that underlie platinum drug toxicity and antitumor activity. Using this information, we hope to develop better drugs such as BNP7787. The reported preclinical studies demonstrate that BNP7787 appears to substantially protect against the common major toxicities of platinum chemotherapy and does not interfere with the antitumor activity of cisplatin. There also appears to be reproducible evidence of enhancement of cisplatin's antitumor effect by BNP7787. Preclinically, we have observed that BNP7787 can safely and effectively protect against very large increases in the dosage of cisplatin, including lethal doses of cisplatin. To our knowledge, no drug has ever been reported in preclinical models to achieve this level of protection against high doses of cisplatin."


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Contact: Neil Cohen
neil@noonanrusso.com
415-677-4455
Noonan/Russo Communications
13-Oct-1998


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