HOME >> MEDICINE >> NEWS
'Biochemical storm' following brain trauma, an important factor in treatment

Oct. 28, 1999, GAINESVILLE---A forceful blow to the head can trigger a "Pacman-like" enzyme to begin gobbling up important structural proteins in the brain for up to one month afterward -- weeks longer than previously suspected, according to a University of Florida Brain Institute researcher.

The finding, based on studies in rats, suggests that treatment for traumatic brain injury must take into account tissue damage that continues to occur long after an accident. Although a number of studies recently have assessed therapies for traumatic brain injury, currently no effective treatment exists. "Emergency room medical personnel often talk about a golden hour, that if you don't get a person into treatment within the first hour or so after an injury, a lot of damage has been done to the patient," said Ronald L. Hayes, director of UF's planned Center for Traumatic Brain Injury Studies, a component of the university's multidisciplinary Brain Institute. "With traumatic brain injury, the thought has been that treatment within the first two days is critical." But data from Hayes' lab suggest this critical period may extend much longer.

"In our studies, we've found that a biochemical storm that is initiated with an injury continues for at least a month. The implication is that we may need to treat these patients over a much longer period than anyone had ever imagined," said Hayes, who reported his findings on the action of calpains on Saturday (10/23) at the annual meeting of the National Neurotrauma Society in Miami Beach. Calpains are a type of protein-destroying enzyme found in cells throughout the body.

"This is one of a very few research efforts that opens up a potential window for treatment in which we might be able to suppress the harmful activity of calpains while allowing repair to occur," said Kevin Wang, a senior research associate at Parke-Davis Pharmaceutical Research who is conducting laboratory experiments seeking to block the action of calpa
'"/>

Contact: Victoria White
vickiwhite@xtalwind.net
352-344-2738
University of Florida
27-Oct-1999


Page: 1 2 3

Related medicine news :

1. US FDA grants full approval to DOXIL(R) following submission of phase III data
2. Patients with abdominal trauma at risk for intra-abdominal infections following surgery
3. Guidelines for following pediatric cancer survivors aim to reduce medical complications
4. Can the standard course of radiation therapy following lumpectomy be shortened?
5. Higher incidence of rejection following early steroid withdrawal
6. Impaired neuromotor function following cancer treatment can improve
7. Significant pain relief following gastric bypass surgery
8. Carbon monoxide from smoking helps keep arteries open following angioplasty
9. CellCept associated with reduced incidence of cancer, compared to AZA, following heart transplant
10. Study shows lower than expected allergic-like events following second prescription of penicillin
11. Hospitals following heart attack guidelines have better outcomes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/22/2017)... ... 22, 2017 , ... John Stewart joins Privis Health as ... t4 Leadership Development & Consulting. He has spent his career focusing on four ... development, servant leadership, data driven process improvement, and supportive technology. These key elements ...
(Date:8/21/2017)... St. Louis, MO (PRWEB) , ... August 22, 2017 , ... ... and career fairs to help healthcare employers connect with physicians and advanced practitioners like ... of virtual career fairs in August through November of this year. The ...
(Date:8/21/2017)... ... 2017 , ... FCPX LUT Monochromatic Volume 2 is an all-new Look-Up Table ... color grades to footage. A LUT is a Lookup Table that contains a mathematical ... color indicated by the table. This pack comes with 60 different monochromatic CUBE LUT ...
(Date:8/21/2017)... ... August 21, 2017 , ... Duncan Insurance Agency debuts ... people of Michigan. The new initiative fundraises for the Kalamazoo Humane Society (KHS), ... of animal protection and welfare by addressing the root causes of pet overpopulation. ...
(Date:8/21/2017)... (PRWEB) , ... August 21, 2017 , ... San Diego ... ) health care reform plan, has announced his candidacy for the 52nd Congressional District ... and shared in America’s Promise. Coming to this country at age eleven after suffering ...
Breaking Medicine News(10 mins):
(Date:8/17/2017)... , Aug. 17, 2017 Bio-Ess Laboratories, LLC Chief Science Officer, ... titer and present new data on Cell-Ess® Universal Titer Boost ... Boston, MA August 21-25.  The Bioprocessing Summit convenes more ... challenges. ... ...
(Date:8/15/2017)... 2017 AccuGenomics, Inc., a diagnostic company based ... that the company has provided an AccuKit to the ... at Chapel Hill and to Qura Therapeutics for evaluation ... quantify HIV reservoir and viral expression in human CD4+ ... Cure Center is a joint initiative between the University ...
(Date:8/10/2017)... , Aug. 10, 2017  Physical Rehabilitation Network (PRN), acquired ... Lakewood, Colorado . The reputable clinic will ... , PT, DPT with his staff of four clinicians. Lipkin ... Pittsburgh and brings over 10 years of experience with a ... Belmar PT marks the 10th PRN clinic in and around ...
Breaking Medicine Technology:
Cached News: