HOME >> MEDICINE >> NEWS
'Biochemical storm' following brain trauma, an important factor in treatment

Oct. 28, 1999, GAINESVILLE---A forceful blow to the head can trigger a "Pacman-like" enzyme to begin gobbling up important structural proteins in the brain for up to one month afterward -- weeks longer than previously suspected, according to a University of Florida Brain Institute researcher.

The finding, based on studies in rats, suggests that treatment for traumatic brain injury must take into account tissue damage that continues to occur long after an accident. Although a number of studies recently have assessed therapies for traumatic brain injury, currently no effective treatment exists. "Emergency room medical personnel often talk about a golden hour, that if you don't get a person into treatment within the first hour or so after an injury, a lot of damage has been done to the patient," said Ronald L. Hayes, director of UF's planned Center for Traumatic Brain Injury Studies, a component of the university's multidisciplinary Brain Institute. "With traumatic brain injury, the thought has been that treatment within the first two days is critical." But data from Hayes' lab suggest this critical period may extend much longer.

"In our studies, we've found that a biochemical storm that is initiated with an injury continues for at least a month. The implication is that we may need to treat these patients over a much longer period than anyone had ever imagined," said Hayes, who reported his findings on the action of calpains on Saturday (10/23) at the annual meeting of the National Neurotrauma Society in Miami Beach. Calpains are a type of protein-destroying enzyme found in cells throughout the body.

"This is one of a very few research efforts that opens up a potential window for treatment in which we might be able to suppress the harmful activity of calpains while allowing repair to occur," said Kevin Wang, a senior research associate at Parke-Davis Pharmaceutical Research who is conducting laboratory experiments seeking to block the action of calpa
'"/>

Contact: Victoria White
vickiwhite@xtalwind.net
352-344-2738
University of Florida
27-Oct-1999


Page: 1 2 3

Related medicine news :

1. US FDA grants full approval to DOXIL(R) following submission of phase III data
2. Patients with abdominal trauma at risk for intra-abdominal infections following surgery
3. Guidelines for following pediatric cancer survivors aim to reduce medical complications
4. Can the standard course of radiation therapy following lumpectomy be shortened?
5. Higher incidence of rejection following early steroid withdrawal
6. Impaired neuromotor function following cancer treatment can improve
7. Significant pain relief following gastric bypass surgery
8. Carbon monoxide from smoking helps keep arteries open following angioplasty
9. CellCept associated with reduced incidence of cancer, compared to AZA, following heart transplant
10. Study shows lower than expected allergic-like events following second prescription of penicillin
11. Hospitals following heart attack guidelines have better outcomes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has ... least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a ... centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 ... characterized by frequent cessation in breathing. Oral appliances can offer significant relief to ...
(Date:10/12/2017)... CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... cold therapy products, announced today the introduction of an innovative new design of the ... multipurpose pad so you get maximum comfort while controlling your pain while using cold ...
(Date:10/12/2017)... ... 2017 , ... Information about the technology: , Otomagnetics has ... prevention of a major side effect of chemotherapy in children. Cisplatin and carboplatin ... cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. Hearing ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... received FDA 510(k) clearance in May 2017 for its highly anticipated ... for endoscopy environments. An innovative secondary monitor solution, ZeroWire Mobile ... the improvement of patient outcomes, procedural efficiency, and the lowering of ... ... By ...
(Date:10/4/2017)...  South Korean-based healthcare product Development Company I.M. Lab ... Kickstarter. The device will educate the user about ,proper, ... efficiency compared to the dated and pricey CPR training ... of the compression for a more informed CPR training. ... raise $5,000. cprCUBE ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology:
Cached News: