Biological Markers Found That Correlate To Esophageal Cancer Treatment Success

horacic Oncology Program.

While physicians have traditionally used only surgery to treat the cancer, clinical trials are under way using chemotherapy and radiation therapy before surgery. However, the trials have demonstrated no benefit to esophageal cancer patients from this so-called "tri-modality" therapy.

The Duke researchers, however, suspect that the patient group studied was too undifferentiated. By studying patients= tumors on a molecular level, they are seeking to identify a subset of patients who are more likely to benefit from the aggressive tri-modality therapy.

Most tumor cells have different genes and proteins activated compared to normal cells. In some cases tumors express genes that normal cells don=t, and in others the tumors lack genes normally expressed. A third option is for a gene to be altered, or mutated, in a way that scientists can detect. All of these changes are reflected in the presence, lack, or mutation of the genes= product proteins.

By examining the pattern of these genetic alterations, Harpole said he hopes to provide a more detailed picture of tumors to eventually predict patients= responses to treatment. The ultimate goal is to tailor therapy and improve survival.

"We want to know if we can predict from the initial biopsy sample which patients will respond to therapy and survive," he said.

In their study of 112 patients, the research team analyzed tumor samples for genes and their protein products that studies of other cancers, such as colon cancer, indicated had roles in either resistance or sensitivity to chemotherapy or radiation.

After biopsy, the patients underwent chemotherapy and radiation therapy, followed by surgery to remove any remaining tumor tissue. The 34 patients who responded completely to the chemotherapy and radiation and had no viable tumor left at surgery had an average survival longer than five years.

In analyzing the relationship between markers and patients= response

Contact: Joanna Downer
Duke University Medical Center

Page: 1 2 3 4

Related medicine news :

1. 2005 Award for Basic Research in Biological Mineralization
2. 2004 Award for Basic Research in Biological Mineralization goes to Dr. Yoshiro Takano
3. Biological marker associated with depression in children uncovered by University of Pittsburgh researchers
4. Biologically inspired electronics leads to higher fidelity
5. Research Links Healthy Biological Clock To Longevity
6. Novel Biological Interaction Found To Explain Blood Vessel Growth To Tumors
7. University Of Pittsburgh Cancer Institute Defines First Immunologic Markers Of Interferon Effectiveness Against Melanoma
8. Can you read my mind? W.M. Keck Foundation funds innovative brain research at Carnegie Mellon
9. Top honor for head of Epilepsy Foundation
10. The Larry King Cardiac Foundation presents The Changing Face of Heart Disease on Feb. 2
11. Prentiss Foundation awards $5 million to University Hospitals

Post Your Comments:

(Date:11/19/2019)... ... November 18, 2019 , ... “Impact of the ... Kindy has been named No. 1 International Best Seller and Hot New Release ... Energy Healing, Nosology, and Alternative Medicine. , Kindy’s study investigated the impact ...
(Date:11/16/2019)... ... 2019 , ... MemoryCare.com , a comprehensive resource for ... Care Facilities in Amarillo, Texas. The guide identifies 5 memory care communities based ... the Alzheimer’s Association , 5.6 million people age 65 and older are ...
(Date:11/15/2019)... ... 2019 , ... Anxiety is sweeping the country in epidemic ... current figures of adults who suffer at 40 million, yet only 36.9% of ... different ways, including Post Traumatic Stress Disorder (PTSD), phobias, Generalized Anxiety Disorder (GAD), ...
(Date:11/14/2019)... ... November 14, 2019 , ... Inland Detox, Inc. is proud ... gastronomical masterpiece for former President Vicente Fox of Mexico. The Chefs Latinos Guanajuato Festival ... President Fox was born and raised on Saturday, November 9, 2019. The event featured ...
(Date:11/14/2019)... (PRWEB) , ... November 14, 2019 , ... ... treatments for cancers and other serious diseases, announced it will have 5 poster ... at the upcoming 24th Annual Society for Neuro-Oncology SNO Meeting in Phoenix, beginning ...
Breaking Medicine News(10 mins):
(Date:11/16/2019)... ... November 15, 2019 , ... Cosmetic surgery continues to be popular in the ... to undergo cosmetic procedures all throughout the United States, the final price can be ... fees and the extent of the work that needs to be performed to achieve ...
(Date:11/15/2019)... CORAL SPRINGS, Fla. (PRWEB) , ... November 15, 2019 , ... ... a continued charitable partnership. Hope For The Warriors was founded by the ... the effects war can have on service members and their families. For the past ...
(Date:11/14/2019)... ... 2019 , ... Algae Health Sciences, a division of BGG, ... on brain health. , In the first study (done in USA), ... overall mood state [psychological well-being] were found after 8 weeks in healthy subjects ...
Breaking Medicine Technology:
Cached News: