HOME >> MEDICINE >> NEWS
Biological Markers Found That Correlate To Esophageal Cancer Treatment Success

to therapy, Harpole found the three protein markers whose presence or absence significantly impacted patient survival.

The presence of one such marker, P-glycoprotein (Pgp), signaled that the patients would not respond well to chemotherapy. Pgp is primarily responsible for inducing multi-drug resistance, in which the tumors become resistant to many chemotherapy drugs after treatment with just one drug. Pgp effectively pumps the drug out of tumor cells before it has time to kill the cells. Pgp is just one protein implicated in multi-drug resistance. Harpole found that the 88 patients with Pgp survived 20.9 months on average, while the 24 patients without Pgp had an average survival of more than 5 years after diagnosis.

Laboratories across the country are looking into ways to stop Pgp or to circumvent its action. One way is to give patients Pgp modulators -- molecules that block Pgp=s drug pump. Another is to develop drugs that Pgp and related proteins can=t remove from the cell.

A second significant marker was glutathione-s-transferase-pi, or GST-pi, which confers radiation resistance. Radiation kills cells by forming oxygen radicals -- highly reactive oxygen atoms that damage DNA. GST-pi reduces these oxygen atoms so that they are no longer reactive. The 84 patients with GST-pi survived an average of 21 months, while those without it survived 47 months on average.

The third implicated marker was HER-2/neu, which initiates chemical signals telling the cell to multiply. Herceptin, a drug recently approved by the FDA to treat breast cancer patients who have excess HER-2/neu, or other agents might eventually be useful in esophageal cancer, Harpole said. Average survival for the 94 HER-2/neu positive patients was 26.8 months, while that for HER-2/neu negative patients was 14.5 months.

The researchers are continuing to study molecular markers, both in esophageal cancer and in lung cancer -- two diseases with survival rates relatively constan
'"/>

Contact: Joanna Downer
downe010@mc.duke.edu
919-684-4148
Duke University Medical Center
15-May-1999


Page: 1 2 3 4

Related medicine news :

1. 2005 Award for Basic Research in Biological Mineralization
2. 2004 Award for Basic Research in Biological Mineralization goes to Dr. Yoshiro Takano
3. Biological marker associated with depression in children uncovered by University of Pittsburgh researchers
4. Biologically inspired electronics leads to higher fidelity
5. Research Links Healthy Biological Clock To Longevity
6. Novel Biological Interaction Found To Explain Blood Vessel Growth To Tumors
7. University Of Pittsburgh Cancer Institute Defines First Immunologic Markers Of Interferon Effectiveness Against Melanoma
8. Can you read my mind? W.M. Keck Foundation funds innovative brain research at Carnegie Mellon
9. Top honor for head of Epilepsy Foundation
10. The Larry King Cardiac Foundation presents The Changing Face of Heart Disease on Feb. 2
11. Prentiss Foundation awards $5 million to University Hospitals

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/2/2020)... ... April 02, 2020 , ... Representatives fighting for ... encouraging their parents, grandparents, and guardians, to file a proof of claim in ... funds will be made available by Purdue as part of its bankruptcy settlement. ...
(Date:4/1/2020)... ... April 01, 2020 , ... ... stay safe while treating Coronavirus-infected patients. , Staffers are in particular need of ... coronavirus. Earlier this week, The Wall Street Journal reported that New York City ...
(Date:3/30/2020)... ... March 30, 2020 , ... ... patients, continuing its commitment to provide comprehensive and compassionate mental health and wellness ... Achieve Medical Center’s UpDox platform for telemedicine services including initial consultations, evaluations, and ...
(Date:3/28/2020)... N.Y. (PRWEB) , ... March 27, 2020 , ... ... protect workers and the public from the spread of the coronavirus. Operating under ... crews are pressing forward with infrastructure renewal and environmental protection projects in the ...
(Date:3/28/2020)... ... March 28, 2020 , ... Confluent Health ... a physical therapist-owned rehabilitation company since 1985 specializing in the treatment of orthopedic, ... we started more than 30 years ago, we have been committed to providing ...
Breaking Medicine News(10 mins):
(Date:3/28/2020)... ... March 27, 2020 , ... Based on his exceptional ... Gallant as its permanent CIO. In this executive leadership team role, Gallant establishes ... provide a smooth shopping experience for customers and digital tools that help independent ...
(Date:3/27/2020)... ... March 27, 2020 , ... A new ... on students' holistic portfolios, revealed that college-bound young adults are reconsidering their higher ... huge new barriers to high school senior’s path to college and possibly dashing ...
(Date:3/22/2020)... ... March 21, 2020 , ... As the spread of ... Department of Thoracic Medicine and Surgery, and the Temple Lung Center have taken ... symptom tracking platform and triage/care coordination services. Temple is now enrolling patients, faculty, ...
Breaking Medicine Technology:
Cached News: