HOME >> MEDICINE >> NEWS
Biological Markers Found That Correlate To Esophageal Cancer Treatment Success

to therapy, Harpole found the three protein markers whose presence or absence significantly impacted patient survival.

The presence of one such marker, P-glycoprotein (Pgp), signaled that the patients would not respond well to chemotherapy. Pgp is primarily responsible for inducing multi-drug resistance, in which the tumors become resistant to many chemotherapy drugs after treatment with just one drug. Pgp effectively pumps the drug out of tumor cells before it has time to kill the cells. Pgp is just one protein implicated in multi-drug resistance. Harpole found that the 88 patients with Pgp survived 20.9 months on average, while the 24 patients without Pgp had an average survival of more than 5 years after diagnosis.

Laboratories across the country are looking into ways to stop Pgp or to circumvent its action. One way is to give patients Pgp modulators -- molecules that block Pgp=s drug pump. Another is to develop drugs that Pgp and related proteins can=t remove from the cell.

A second significant marker was glutathione-s-transferase-pi, or GST-pi, which confers radiation resistance. Radiation kills cells by forming oxygen radicals -- highly reactive oxygen atoms that damage DNA. GST-pi reduces these oxygen atoms so that they are no longer reactive. The 84 patients with GST-pi survived an average of 21 months, while those without it survived 47 months on average.

The third implicated marker was HER-2/neu, which initiates chemical signals telling the cell to multiply. Herceptin, a drug recently approved by the FDA to treat breast cancer patients who have excess HER-2/neu, or other agents might eventually be useful in esophageal cancer, Harpole said. Average survival for the 94 HER-2/neu positive patients was 26.8 months, while that for HER-2/neu negative patients was 14.5 months.

The researchers are continuing to study molecular markers, both in esophageal cancer and in lung cancer -- two diseases with survival rates relatively constan
'"/>

Contact: Joanna Downer
downe010@mc.duke.edu
919-684-4148
Duke University Medical Center
15-May-1999


Page: 1 2 3 4

Related medicine news :

1. 2005 Award for Basic Research in Biological Mineralization
2. 2004 Award for Basic Research in Biological Mineralization goes to Dr. Yoshiro Takano
3. Biological marker associated with depression in children uncovered by University of Pittsburgh researchers
4. Biologically inspired electronics leads to higher fidelity
5. Research Links Healthy Biological Clock To Longevity
6. Novel Biological Interaction Found To Explain Blood Vessel Growth To Tumors
7. University Of Pittsburgh Cancer Institute Defines First Immunologic Markers Of Interferon Effectiveness Against Melanoma
8. Can you read my mind? W.M. Keck Foundation funds innovative brain research at Carnegie Mellon
9. Top honor for head of Epilepsy Foundation
10. The Larry King Cardiac Foundation presents The Changing Face of Heart Disease on Feb. 2
11. Prentiss Foundation awards $5 million to University Hospitals

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/19/2019)... ... November 18, 2019 , ... ... for the scientific and healthcare industries, announced today the asset acquisition of ... known as Advantage Business Media) ceased operations after 13 years in June ...
(Date:11/19/2019)... ... November 19, 2019 , ... iPatientCare, a pioneer ... Patient Engagement solutions, announces Virtual User Conference (VUCON), which will highlight the impact ... better patient-centric experience. , VUCON sessions are designed to demonstrate ...
(Date:11/16/2019)... (PRWEB) , ... November 15, 2019 , ... ... adults living with memory impairment, has announced the Best Memory Care Facilities in ... to experts, facility features and amenities. , According to the Alzheimer’s ...
(Date:11/16/2019)... VEGAS (PRWEB) , ... November 15, 2019 , ... ... seen before in the United States, access to cannabis via well-managed dispensaries becomes ... marijuana industry. Wise Business Plans, industry-leading online provider of state-of-the-art, online, custom cannabis ...
(Date:11/16/2019)... LAUDERDALE, Fla. (PRWEB) , ... November 16, 2019 ... ... uniform provider to support AdventHealth, one of the nation’s largest faith-based health systems, ... kicked off a massive program implementation process – from product selection to fitting ...
Breaking Medicine News(10 mins):
(Date:11/19/2019)... ... 2019 , ... “Impact of the Biofield Energy Healing Based ... been named No. 1 International Best Seller and Hot New Release on Amazon ... Theory, and Mind-Body Connection in the USA, Canada, United Kingdom, and Australia. ...
(Date:11/19/2019)... ... 19, 2019 , ... HashCash Consultants is going to aid a major Pharma ... research initiative for precision drugs. , The collaboration is expected to streamline the process ... have more control over their genome records and the way it is used. They ...
(Date:11/16/2019)... ... 16, 2019 , ... International Splash Awards 2019 winners were announced and Srijan ... Srijan got nominated for its efforts at the world-class competition acknowledging the best Drupal ... tools and apps category. The event was organized in conjunction with DrupalCon Amsterdam on ...
Breaking Medicine Technology:
Cached News: