HOME >> MEDICINE >> NEWS
Blocking enzyme found to ease anxiety without causing sedation

The trouble with most anti-anxiety drugs is that they tend to sedate, not just relax. A research team led by scientists at UCSF's Ernest Gallo Clinic and Research Center has shown that de-activating a common enzyme in neurons reduces anxiety without inducing sedation. The study in mice suggests a new route to treat anxiety while avoiding sedating and possibly addicting effects.

The research, published in the October issue of The Journal of Clinical Investigation, also showed that blocking the enzyme reduced levels of stress hormones. The same issue of the journal includes a commentary on the research (Anxiolytic Drug Targets: Beyond the Usual Suspects) by Joshua A. Gordon of Columbia University's Center for Neurobiology and Behavior.

Anti-anxiety drugs such as Valium often leave people sedated, less capable at mental tasks, and can become addicting, whereas drugs without these side effects -- such as some antidepressants -- may not reduce anxiety as well, said Robert Messing, MD, UCSF professor of neurology at the Gallo Research Center and senior author on the paper.

But in the new study, mice lacking the enzyme showed reduced anxiety while maintaining normal levels of alertness and learning abilities, the researchers reported.

The enzyme, known as protein kinase C epsilon (PKC epsilon), is present in many neurons in the brain, but its role is not well known. Its ability to affect anxiety but not sedation may stem from indirect, rather than direct action, the researchers found.

When the neurotransmitter GABA binds to proteins on the surface of many neurons, known as GABA-A receptors, the neurons become less active, which tends to reduce anxiety. Drugs such as Valium act by increasing the action of GABA at the GABA-A receptors. A group of brain molecules derived from progesterone, known as neurosteroids, also act to increase the action at the GABA-A receptor, and thereby reduce anxiety. But PKC epsilon appears to make the GA
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415 476-2557
University of California - San Francisco
2-Oct-2002


Page: 1 2

Related medicine news :

1. Blocking molecules protects health of implants
2. Blocking selected neurotransmitter activity may decrease alcohol consumption
3. Blocking immune response to spinal cord injury can improve chances for recovery
4. Blocking pathway overcomes tumor vessel resistance to radiation
5. Blocking adhesion protein may reduce lung damage from radiation
6. Blocking gene may reduce lung scarring caused by radiation therapy
7. Scientists discover enzyme crucial to the transportation of proteins within cells
8. Scientists discover enzyme crucial to HIV replication
9. Study shows coenzyme Q10 may prevent migraine
10. New information about heart enzymes could lead to better treatments
11. Researchers identify enzyme that may turn fleeting experience into lasting memory

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Blocking enzyme found ease anxiety without causing sedation

(Date:11/27/2014)... MN (PRWEB) November 27, 2014 ... of office ergonomics equipment , has announced that ... with Commercial Office Environments. The partnership will put ... office furnishings location. , In addition to having ... new dealer partnership promotes HealthPostures' products with the ...
(Date:11/27/2014)... 27, 2014 At The Little Gym, ... it came as no surprise when a recent study ... academic success. The Journal of Pediatrics found ... motor tasks during the school years may be important ... development.” The study monitored two groups of children; those ...
(Date:11/27/2014)... 2014 Ethane Web Technologies, which is ... online reputation management service. , The company has ... the world of internet marketing and algorithms of major ... Ethane Web Technologies does not work with the same ... project to reach a conclusion what will work for ...
(Date:11/27/2014)... VeloReality Inc. President Gary Bauer announced the release ... world-famous velo courses for the company's VRide software and ... velo trainers. Two dozen additional Real Life Videos videos will ... -- in time for the 2014 holiday gift-giving season, ... VeloReality collection to over sixty. , The new Majorca Grand ...
(Date:11/27/2014)... Serious Buyer, Andrew Hawley from Vintage Rock ... Memorial Coliseum concert posters. Between 1969 and 1977 many ... of Alabama. Jimi Hendrix started the concert series on ... Gary Weinberger who was a freshman at the University ... council was responsible for bringing music acts to the ...
Breaking Medicine News(10 mins):Health News:Ergonomics Manufacturer Announces New Partnership with Office Supply Dealer 2Health News:Ethane Web Technologies Announces Online Reputation Management Service 2Health News:Winter 2015 Weather Forecast Is Warm and Dry For VeloReality Riders With New RLV Offering 2Health News:Winter 2015 Weather Forecast Is Warm and Dry For VeloReality Riders With New RLV Offering 3Health News:Serious Buyer Announces His Search For Vintage 1969 Jimi Hendrix Tuscaloosa Memorial Coliseum Concert Posters 2
(Date:11/26/2014)... 26, 2014 Zynerba Pharmaceuticals , Inc., ... innovative transdermal synthetic cannabinoid treatments, today announced that the ... Healthcare Conference 2014. The conference will be held December ... New York . Zynerba,s Chairman and ... pm on Tuesday, December 2. To listen ...
(Date:11/26/2014)... , Nov. 26, 2014  Aridis Pharmaceuticals, ... produce novel therapies for infectious diseases, announced today ... an internationally recognized key opinion leader in the ... scientific advisory board. Founder and Chief ... "We believe Dr. Opal,s extensive experience investigating bacterial ...
(Date:11/26/2014)... and NEW YORK ... As the leading distributor of market intelligence, ... new research report by IQ4I Research and Consultancy focusing ... To learn more about IQ4I Research visit: ... Active Pharmaceutical Ingredients Global Market – Forecast to ...
Breaking Medicine Technology:Zynerba Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 2014 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 3MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 2MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 3
Cached News: