HOME >> MEDICINE >> NEWS
Blocking enzyme found to ease anxiety without causing sedation

The trouble with most anti-anxiety drugs is that they tend to sedate, not just relax. A research team led by scientists at UCSF's Ernest Gallo Clinic and Research Center has shown that de-activating a common enzyme in neurons reduces anxiety without inducing sedation. The study in mice suggests a new route to treat anxiety while avoiding sedating and possibly addicting effects.

The research, published in the October issue of The Journal of Clinical Investigation, also showed that blocking the enzyme reduced levels of stress hormones. The same issue of the journal includes a commentary on the research (Anxiolytic Drug Targets: Beyond the Usual Suspects) by Joshua A. Gordon of Columbia University's Center for Neurobiology and Behavior.

Anti-anxiety drugs such as Valium often leave people sedated, less capable at mental tasks, and can become addicting, whereas drugs without these side effects -- such as some antidepressants -- may not reduce anxiety as well, said Robert Messing, MD, UCSF professor of neurology at the Gallo Research Center and senior author on the paper.

But in the new study, mice lacking the enzyme showed reduced anxiety while maintaining normal levels of alertness and learning abilities, the researchers reported.

The enzyme, known as protein kinase C epsilon (PKC epsilon), is present in many neurons in the brain, but its role is not well known. Its ability to affect anxiety but not sedation may stem from indirect, rather than direct action, the researchers found.

When the neurotransmitter GABA binds to proteins on the surface of many neurons, known as GABA-A receptors, the neurons become less active, which tends to reduce anxiety. Drugs such as Valium act by increasing the action of GABA at the GABA-A receptors. A group of brain molecules derived from progesterone, known as neurosteroids, also act to increase the action at the GABA-A receptor, and thereby reduce anxiety. But PKC epsilon appears to make the GA
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415 476-2557
University of California - San Francisco
2-Oct-2002


Page: 1 2

Related medicine news :

1. Blocking molecules protects health of implants
2. Blocking selected neurotransmitter activity may decrease alcohol consumption
3. Blocking immune response to spinal cord injury can improve chances for recovery
4. Blocking pathway overcomes tumor vessel resistance to radiation
5. Blocking adhesion protein may reduce lung damage from radiation
6. Blocking gene may reduce lung scarring caused by radiation therapy
7. Scientists discover enzyme crucial to the transportation of proteins within cells
8. Scientists discover enzyme crucial to HIV replication
9. Study shows coenzyme Q10 may prevent migraine
10. New information about heart enzymes could lead to better treatments
11. Researchers identify enzyme that may turn fleeting experience into lasting memory

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/20/2019)... ... June 20, 2019 , ... SightMD (or the ... Founders, announced a strategic partnership with Northern Westchester Ophthalmology, P.C. (“NWO”) and its ... in New York, adding the Company’s first location in Westchester County to SightMD’s ...
(Date:6/19/2019)... ... 19, 2019 , ... The number of public health departments ... of performance continues to climb. Today, the Public Health Accreditation Board ... public health departments. With this week's accreditation decisions, tens of thousands more people ...
(Date:6/19/2019)... ... June 19, 2019 , ... The ... Congress (IRC) in Marseille, France. The conference is widely seen as the ... muscular dystrophy (FSHD). Nearly 200 researchers, clinicians, industry representatives and patient advocates are ...
(Date:6/18/2019)... ... June 18, 2019 , ... EMulate Therapeutics, Inc. ... serious diseases, announced it has received notice that the US Food and Drug ... (HDE) for the Hælo Pediatric system. The FDA granted the Humanitarian Use ...
(Date:6/18/2019)... ST. LOUIS (PRWEB) , ... June 18, 2019 ... ... cost, quality and clinical outcomes, today announced Steve Einig has joined the organization ... will lead strategy and corporate initiatives around market engagement, marketing, strategic events and ...
Breaking Medicine News(10 mins):
(Date:6/19/2019)... RESEDA, California (PRWEB) , ... June 19, 2019 , ... ... women living together at the Los Angeles Jewish Home (LAJH). Known as a destination ... For many seniors, including Edith Frankie, Linda Frankes, and Mildred Moccio, it is also ...
(Date:6/19/2019)... ... June 19, 2019 , ... Center for Vein Restoration (CVR) CEO and ... Top CEOs in 2019 . Glassdoor , one of the world’s largest ... world-class leaders that employees love working for throughout North America and parts of Europe. ...
(Date:6/19/2019)... (PRWEB) , ... June 19, 2019 , ... Senior citizens ... age and this vitality can be a double-edged sword leading seniors to put off ... living specialists and Certified Senior Advisors at Elder Placement Professionals have some suggestions ...
Breaking Medicine Technology:
Cached News: