HOME >> MEDICINE >> NEWS
Blocking enzyme found to ease anxiety without causing sedation

The trouble with most anti-anxiety drugs is that they tend to sedate, not just relax. A research team led by scientists at UCSF's Ernest Gallo Clinic and Research Center has shown that de-activating a common enzyme in neurons reduces anxiety without inducing sedation. The study in mice suggests a new route to treat anxiety while avoiding sedating and possibly addicting effects.

The research, published in the October issue of The Journal of Clinical Investigation, also showed that blocking the enzyme reduced levels of stress hormones. The same issue of the journal includes a commentary on the research (Anxiolytic Drug Targets: Beyond the Usual Suspects) by Joshua A. Gordon of Columbia University's Center for Neurobiology and Behavior.

Anti-anxiety drugs such as Valium often leave people sedated, less capable at mental tasks, and can become addicting, whereas drugs without these side effects -- such as some antidepressants -- may not reduce anxiety as well, said Robert Messing, MD, UCSF professor of neurology at the Gallo Research Center and senior author on the paper.

But in the new study, mice lacking the enzyme showed reduced anxiety while maintaining normal levels of alertness and learning abilities, the researchers reported.

The enzyme, known as protein kinase C epsilon (PKC epsilon), is present in many neurons in the brain, but its role is not well known. Its ability to affect anxiety but not sedation may stem from indirect, rather than direct action, the researchers found.

When the neurotransmitter GABA binds to proteins on the surface of many neurons, known as GABA-A receptors, the neurons become less active, which tends to reduce anxiety. Drugs such as Valium act by increasing the action of GABA at the GABA-A receptors. A group of brain molecules derived from progesterone, known as neurosteroids, also act to increase the action at the GABA-A receptor, and thereby reduce anxiety. But PKC epsilon appears to make the GA
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415 476-2557
University of California - San Francisco
2-Oct-2002


Page: 1 2

Related medicine news :

1. Blocking molecules protects health of implants
2. Blocking selected neurotransmitter activity may decrease alcohol consumption
3. Blocking immune response to spinal cord injury can improve chances for recovery
4. Blocking pathway overcomes tumor vessel resistance to radiation
5. Blocking adhesion protein may reduce lung damage from radiation
6. Blocking gene may reduce lung scarring caused by radiation therapy
7. Scientists discover enzyme crucial to the transportation of proteins within cells
8. Scientists discover enzyme crucial to HIV replication
9. Study shows coenzyme Q10 may prevent migraine
10. New information about heart enzymes could lead to better treatments
11. Researchers identify enzyme that may turn fleeting experience into lasting memory

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Blocking enzyme found ease anxiety without causing sedation

(Date:8/31/2015)... , ... August 31, 2015 , ... The Sundance Film ... on Tuesday, September 1. , “Alive Inside” shadows a social worker who advocates for ... , “It’s a documentary about bringing music to residents in health care centers who ...
(Date:8/31/2015)... ... September 01, 2015 , ... Neuropsychiatric ... injury with emphasis on transcranial near-infrared laser phototherapy ”. , As corresponding author ... has been largely untreatable - with mostly palliative treatments only - and now ...
(Date:8/31/2015)... ... August 31, 2015 , ... David L. Chalnick, ... one of the first doctors in the area to perform minimally invasive hip ... been impressive: faster recovery, decreased immediate and long-term pain, and an accelerated return ...
(Date:8/31/2015)... ... ... NJ Top Docs Presents, Dr. Michael Betsy! Dr. Betsy has been reviewed and approved ... Betsy graduated from Don Bosco Prep in 1990 and was Class Salutatorian. He earned ... in his senior year. He was inducted into the National Honor Society as a ...
(Date:8/31/2015)... Viejo, CA (PRWEB) , ... August 31, 2015 , ... With the FCPX LUT Soft ... footage. A LUT is a Lookup Table that contains a mathematical formula for modifying an ... This pack comes with 60 soft CUBE LUT files. , FCPX LUT Soft requires ...
Breaking Medicine News(10 mins):Health News:Public Invited to Dementia Documentary Screening at North Carolina Retirement Community 2Health News:Near-Infrared Laser Phototherapy for Brain Injury published by Dove Medical Press 2Health News:Near-Infrared Laser Phototherapy for Brain Injury published by Dove Medical Press 3Health News:NJ Top Docs Presents, Dr. David L. Chalnick! 2Health News:NJ Top Docs Presents, Dr. David L. Chalnick! 3Health News:NJ Top Docs Presents, Dr. David L. Chalnick! 4Health News:NJ Top Docs Presents, Dr. Michael Betsy! 2Health News:NJ Top Docs Presents, Dr. Michael Betsy! 3Health News:Pixel Film Studios, FCPX Plugin Developer, Releases FCPX LUT Soft 2
(Date:8/31/2015)... Bionomics Limited (ASX:BNO, ADR:BMICY), a biopharmaceutical company ... for the treatment of diseases of the central nervous ... IND submission has passed review by the US Food ... Phase 1 clinical trial in patients with metastatic colon ... to 31 December 2015. Bionomics, CEO & ...
(Date:8/31/2015)... DUBLIN , Aug. 31, 2015 ... the addition of the "Prescription Pain Drugs ... Medical Marijuana - Global Markets, Competitors and Opportunities: ... to their offering. Pain is ... associated with actual or potential tissue damage. At ...
(Date:8/30/2015)... y LONDRES, August 30, 2015 ... visión holística de l cuidado al ... trayecto   Royal Philips  ... debut europeo de IntelliSpace Cardiovascular , un sistema ... sofisticadas herramientas para acceder, analizar y compartir imágenes cardiovasculares ...
Breaking Medicine Technology:Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 2Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 3Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 4Prescription Pain Drugs Including Opioid, Anticonvulsant, Injectable/ Inhaled, Topical/ Transdermal, Medical Marijuana - 2015-2020 Analysis and Forecasts 2Prescription Pain Drugs Including Opioid, Anticonvulsant, Injectable/ Inhaled, Topical/ Transdermal, Medical Marijuana - 2015-2020 Analysis and Forecasts 3Philips presenta IntelliSpace Cardiovascular en el Congreso ESC 2015 2Philips presenta IntelliSpace Cardiovascular en el Congreso ESC 2015 3
Cached News: