HOME >> MEDICINE >> NEWS
Blocking immune response to spinal cord injury can improve chances for recovery

Irvine, Calif., Nov. 13, 2003 -- People who suffer spinal cord injuries may have a greater chance of recovery if treated with drugs that block the body's own immune response to the initial trauma, researchers from the Reeve-Irvine Research Center at UC Irvine have found. In addition, UCI neurologist Hans Keirstead and immunologist Thomas Lane have laid the foundation for these drugs by creating antibodies that, when tested on rats, stopped the secondary nerve and spinal cord damage caused by the immune system response. Use of these antibodies resulted in significantly improved rates of recovery.

Previous studies have shown that the body's immediate immune system response to a spinal cord injury actually worsens the condition. Results of this UCI study appear in the November issue of Experimental Neurology.

"While the primary tissue damage caused by the initial spinal trauma cannot be reversed, we've discovered that the secondary damage caused by immune responses can be prevented, which gives those who suffer these injuries hope for recovery," Keirstead said.

Immediately after spinal cord trauma, cells called chemokines are released at the injury site and induce inflammation. One specific chemokine called CXCL-10 recruits immune system cells called T-lymphocytes. Normally, T-cells battle disease and other invading agents in the body, but in the central nervous system during spinal injury and periods of disease in multiple sclerosis, these T-cells create toxic compounds that attack and damage spinal tissue and nerve fibers.

In tests on rats with induced spinal cord injuries, Keirstead and Lane treated one group with their antibody drugs that blocked CXCL-10 cells from recruiting T-cells to the injury site. Another group received no therapies. In the group treated with the antibodies, the researchers found a significant reduction in T-cell counts and spinal damage. The untreated rats showed increased T-cell levels and greater secondary tissue d
'"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
13-Nov-2003


Page: 1 2 3

Related medicine news :

1. Blocking molecules protects health of implants
2. Blocking selected neurotransmitter activity may decrease alcohol consumption
3. Blocking enzyme found to ease anxiety without causing sedation
4. Blocking pathway overcomes tumor vessel resistance to radiation
5. Blocking adhesion protein may reduce lung damage from radiation
6. Blocking gene may reduce lung scarring caused by radiation therapy
7. Chemists identify immune system mechanism for methamphetamine binges
8. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
9. Smart immune cells kill more cancer
10. New network of gastrointestinal immune cells discovered
11. Old T cells cripple immune function in the elderly

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... ... 1,400 N95 face masks to medical first responders across the United States. Since ... donations of personal protective equipment (PPE) medical centers , hospitals , ...
(Date:8/31/2020)... ... 2020 , ... Smile Brands Inc., one of the nation’s ... today announced the grand opening of another affiliated Bright Now! Dental office ... hours, a comfortable office, and full-service care at the new Beaumont location. The ...
(Date:8/31/2020)... ... August 31, 2020 , ... Dr. ... with persons with autism and other developmental disabilities, as well as supporting staff ... education, adolescents with autism, school consultation, and staff development. She joined the company ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... designed to help treat patients with respiratory conditions, including COVID-19, while reducing the ... and oxygen, but it captures exhaled gas and scrubs it free of carbon ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ziegler, a specialty investment bank, ... in Synchronous Health, a tech-enabled behavioral health and well-being solutions provider. , ... with artificial intelligence (AI) to increase access and quality of behavioral health services, ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... Mara C. Weinstein Velez, ... at the University of Rochester Medical Center, in Upstate New York. She completed ... with clinical faculty from the Harvard and Yale Departments of Dermatology and is ...
(Date:8/31/2020)... Israel (PRWEB) , ... August 31, 2020 , ... ... specialize in wellness-related technologies, today announced that they have invested $400,000 in PopBase, ... that ran in collaboration with the Global Wellness Institute (GWI). , The ...
(Date:8/28/2020)... ... ... Dr. Mark Surrey has been in practice for over 25 years. He ... the Department of OBGYN at UCLA’s David Geffen School of Medicine. , He ... is a Clinical Director of Fellowship Training for UCLA & Cedars Sinai Reproductive Endocrinology. ...
Breaking Medicine Technology:
Cached News: