HOME >> MEDICINE >> NEWS
Blocking immune response to spinal cord injury can improve chances for recovery

Irvine, Calif., Nov. 13, 2003 -- People who suffer spinal cord injuries may have a greater chance of recovery if treated with drugs that block the body's own immune response to the initial trauma, researchers from the Reeve-Irvine Research Center at UC Irvine have found. In addition, UCI neurologist Hans Keirstead and immunologist Thomas Lane have laid the foundation for these drugs by creating antibodies that, when tested on rats, stopped the secondary nerve and spinal cord damage caused by the immune system response. Use of these antibodies resulted in significantly improved rates of recovery.

Previous studies have shown that the body's immediate immune system response to a spinal cord injury actually worsens the condition. Results of this UCI study appear in the November issue of Experimental Neurology.

"While the primary tissue damage caused by the initial spinal trauma cannot be reversed, we've discovered that the secondary damage caused by immune responses can be prevented, which gives those who suffer these injuries hope for recovery," Keirstead said.

Immediately after spinal cord trauma, cells called chemokines are released at the injury site and induce inflammation. One specific chemokine called CXCL-10 recruits immune system cells called T-lymphocytes. Normally, T-cells battle disease and other invading agents in the body, but in the central nervous system during spinal injury and periods of disease in multiple sclerosis, these T-cells create toxic compounds that attack and damage spinal tissue and nerve fibers.

In tests on rats with induced spinal cord injuries, Keirstead and Lane treated one group with their antibody drugs that blocked CXCL-10 cells from recruiting T-cells to the injury site. Another group received no therapies. In the group treated with the antibodies, the researchers found a significant reduction in T-cell counts and spinal damage. The untreated rats showed increased T-cell levels and greater secondary tissue d
'"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
13-Nov-2003


Page: 1 2 3

Related medicine news :

1. Blocking molecules protects health of implants
2. Blocking selected neurotransmitter activity may decrease alcohol consumption
3. Blocking enzyme found to ease anxiety without causing sedation
4. Blocking pathway overcomes tumor vessel resistance to radiation
5. Blocking adhesion protein may reduce lung damage from radiation
6. Blocking gene may reduce lung scarring caused by radiation therapy
7. Chemists identify immune system mechanism for methamphetamine binges
8. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
9. Smart immune cells kill more cancer
10. New network of gastrointestinal immune cells discovered
11. Old T cells cripple immune function in the elderly

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... ... May 28, 2020 , ... Officials with ... clinically integrated network (CIN) and the group purchasing organization run by Allegheny Health ... establish a heart failure program at Mon Health Medical Center. ...
(Date:5/27/2020)... ... May 27, 2020 , ... The podiatrists and foot doctors ... Michigan, Fowlerville Michigan , and Ann Arbor Michigan. Dr. Tomasz Biernacki ... within the clinic and at the hospital. We have been seeing patients in the ...
(Date:5/26/2020)... ... May 26, 2020 , ... Loyale ... patient messaging and IVR Advantage™--for Loyale customers. Talksoft pre-service messaging solutions complement ... texts, IVR reminders and email messages tailored to each stage of their ...
(Date:5/25/2020)... ... May 23, 2020 , ... Winemaker Grant Long Jr. is introducing three Toilet ... whimsical and delicious in these complicated times,” he said, in announcing the new wines. ... ($24.99). The Chardonnay and Red Wine Blend are sourced in the Napa Valley; the ...
(Date:5/21/2020)... Pa. (PRWEB) , ... May 21, 2020 , ... ... Inc. and an industry leader in cancer biomarker assays, announced today that Cigna ... list. Cigna Corporation is a global health service company dedicated to improving the ...
Breaking Medicine News(10 mins):
(Date:6/2/2020)... ... June 02, 2020 , ... As the leading human capital ... COVID-19 it is working with its corporate team, its consultants, and its healthcare ... host of digital resources. Harmony’s leadership team recognized the extraordinary efforts of the ...
(Date:6/2/2020)... ... June 02, 2020 , ... SCFHP members who call SCFHP’s 24/7 ... and, depending on the inquiry, can now virtually consult with an available physician. Once ... their primary care doctor to ensure seamless care. The nurse advice line with the ...
(Date:5/30/2020)... DALLAS (PRWEB) , ... May 29, 2020 , ... ... launched a unique return-to-work mobile and web based solution People1 Care ... People1 Care helps companies transition into the 'new normal’ through daily wellness screenings, ...
Breaking Medicine Technology:
Cached News: