HOME >> MEDICINE >> NEWS
Blocking molecules protects health of implants

New Haven, Conn.--Blocking a key molecule protects breast implants, permanent catheters, pacemakers, artificial joints, glucose sensors for diabetics, and other biomaterials from rejection and damage by the body, according to a study published this month in The American Journal of Pathology.

The more complicated the function of the implant, the more likely it is to be rendered non-functional due to damage induced by the body, said the lead author, Themis Kyriakides, assistant professor of pathology and a member of the interdepartmental program in Vascular Biology and Transplantation at Yale School of Medicine.

"Implantation of biomaterials and tissue-engineered devices into tissues cause the development of a foreign body reaction that can lead to implant failure," Kyriakides said. "The foreign body reaction has been implicated in the malfunction and failure of numerous devices and implants."

Kyriakides and his colleagues focused on the area of contact between the tissue and the implant, or biomaterial, where foreign body giant cells are formed from the fusion of recruited inflammatory cells that attack the implant. The CC chemokine ligand (CCL)-2, previously known as monocyte chemoattractant protein (MCP)-1, is believed to be responsible for the recruitment of foreign body giant cell precursors to the implant site. This study examined what would happen if the expression or function of CCL2 was eliminated both in mice genetically engineered without the molecule and in other mice where the function of CCL2 was blocked by means of a protein decoy via localized gene delivery.

"What we found is that in the absence of CCL2 these large cells do not form at the site of the implant, therefore protecting the implant from damage," Kyriakides said. He said the significance of the finding is discovering a new and more complex role for CCL2 in the foreign body response. The success at blocking the CCL2 in mice using a protein decoy also paves the w
'"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
20-Dec-2004


Page: 1 2

Related medicine news :

1. Blocking selected neurotransmitter activity may decrease alcohol consumption
2. Blocking immune response to spinal cord injury can improve chances for recovery
3. Blocking enzyme found to ease anxiety without causing sedation
4. Blocking pathway overcomes tumor vessel resistance to radiation
5. Blocking adhesion protein may reduce lung damage from radiation
6. Blocking gene may reduce lung scarring caused by radiation therapy
7. Medical molecules designed to respond to visible light that can penetrate tissue
8. ASU researchers demonstrate new nanotech effect - moving water molecules by light
9. Student builds micro biosensor chip to move DNA molecules
10. Laser method identifies, counts toxic molecules
11. Vision-producing cells fail taste-test, treat key light-detecting molecules identically

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... ... September 01, 2020 , ... ... fellowship training in aesthetic surgery of the face, breast, and body. In 2018, ... female-owned premier boutique plastic surgery and aesthetic practice in Southwest Florida. Dr. Gill ...
(Date:8/31/2020)... ... ... Want to get moving, break up your routine, and make a difference right ... its fourth annual STEPtember campaign in the United States to raise funds and awareness ... at this moment — encouraging people to move in the ways that work for ...
(Date:8/31/2020)... ... ... Covid-19 “PTS” with Mediation & Hypnosis , At this very turbulent time in the ... anxiety, immense stress, and right now are needing serious relief from a constant state of ... are experiencing a great degree of emotional discomfort, be it fear or worrying about their ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ernst & Young LLP ... an Entrepreneur Of The Year® 2020 Florida Award finalist. Now in its 34th ... deliver innovation, growth and prosperity as they build and sustain successful businesses that ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ziegler, ... Health on its investment in Synchronous Health, a tech-enabled behavioral health and well-being ... strength of human empathy with artificial intelligence (AI) to increase access and quality ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... August 27, 2020 , ... Trella Health, the leading ... provider of cloud CRM, marketing automation, and contact center solutions for senior living ... integration of Trella’s performance intelligence data and insights into Enquire’s CRM solution to ...
(Date:8/26/2020)... ... 26, 2020 , ... AseptiScope, a privately funded San Diego, California based, clinical ... MedTech Outlook. , “AseptiScope is pleased to receive this recognition,” said Kelly ... gloves on their hands, goggles on their eyes, covers on their shoes, and gowns ...
(Date:8/26/2020)... ... August 26, 2020 , ... As the U.S. struggles in its 6th month ... the Coronavirus. Wear a mask, keep your distance, wash your hands. Prevention is the ... it best in 1977, “How much better it is to prevent disease than to ...
Breaking Medicine Technology:
Cached News: