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Blocking selected neurotransmitter activity may decrease alcohol consumption

ggest that L-152,804 might reduce the motivation to start drinking as well as decrease the amount of alcohol consumed. Thus, L-152,804 might make relapse less likely and possibly dampen its consequences.

Both Hodge and Pandey said these results have clear implications for the medical management of alcohol abuse and alcoholism.

"If these studies are replicable and consistently produce findings that alcohol preference and dependence are associated with increased NPY-Y5 receptors in the brain," said Pandey, "then blocking these receptors with L-152, 804 may be useful in treating alcoholism. Furthermore, since this receptor antagonist is able to delay the onset of alcohol-drinking behaviors in alcohol-preferring mice, it also has potential in preventing relapse to alcohol abuse."

"Approved medications for alcoholism such as naltrexone," added Hodge, "may help prevent relapse but do not decrease drinking by chronic alcoholics who are actively drinking. L-152,804 has the potential to both prevent relapse and decrease active drinking. When you also consider the fact that L-152,804 can be administered orally, we believe that medications that block NPY actions at its receptors have great potential for the medical management of alcoholism."


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14-Dec-2003


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