"Goal-setting for patients with type 1 diabetes is more complex because of the higher occurrence of microvascular complications that we have shown to be related to blood lipids and blood pressure levels as well," Dr. Orchard said. "Additional complications are caused by the relationship between renal disease and coronary artery disease in people with type 1."

Also, because people with type 1 often have had diabetes and the accompanying risk factors since childhood, resulting diseases are more likely to manifest themselves over time in these patients than in people with type 2, who normally develop diabetes in adulthood.

During the 10-year period, 67 subjects died, 105 developed coronary artery disease, 92 developed lower-extremity arterial disease, 52 developed overt nephropathy, 120 developed distal symmetrical polyneuropathy, and 148 developed proliferative retinopathy. Adjustments for age and gender were generally minor.

'"/>

Contact: Kathryn Duda
dudak@msx.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
23-May-2001