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Blood pressure drug helps delay ischemic brain damage in stroke patients

SAN FRANCISCO A drug used to lower blood pressure can help stop or delay the progress of further ischemic brain lesions in stroke patients according to research that will be presented at the American Academy of Neurology 56th Annual Meeting in San Francisco, Calif., April 24 May 1, 2004.

For the study, researchers surveyed 226 people with prior cerebrovascular disease (stroke or TIA--transient ischemic attack). All study participants received either the ACE inhibitor perindopril (4mg daily) or placebo(s). All participants had a cerebral MRI at the beginning of the study and a follow-up MRI examination three years later to measure the presence and volume of incidental white matter lesions. The prevalence of white matter lesions increases with age, is strongly associated with hypertension, and has been shown to increase the risk of dementia, severe cognitive impairment, or gait disturbances.

"Overall, the volume of new white matter lesions in the patients who took the placebo was 5 times higher compared to those who received the blood pressure medication--and more than 7.5 times higher for those patients who had severe white matter lesions upon entry," said study co-author Carole Dufouil, PhD, researcher at unit 360 of INSERM (Institut National de la Sant et de la Recherche Mdicale) located at Hopital La Salpetriere, Paris, France. "Of those patients in the active treatment group who had severe white matter lesions upon entry, none experienced an increase in lesions. The results clearly indicate that a blood pressure lowering regimen in stroke patients stops or delays further ischemic brain damage."


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Contact: Kathy Stone
kstone@aan.com
651-695-2763
American Academy of Neurology
27-Apr-2004


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