Blood screen may help cancer patients thwart radiation side effects, say Stanford researchers

nes, or the same genes at different levels, compared with normal cells exposed to radiation.

A group of graduate students and medical students consisting of Kerri Rieger, Wan-Jen Hong, Virginia Goss Tusher and Jean Tang tested this idea in blood samples taken from 57 cancer patients who had recently received radiation treatment. Of these, 14 patients had unusually severe radiation toxicity. The students used a gene microarray, which provides a snapshot of gene activity, to analyze which genes were active in blood cells.

In the initial analysis, Chu said the group couldn't identify genes that were consistently different between patients who did and didn't suffer serious side effects. He worked with Robert Tibshirani, PhD, professor of health research and policy, to develop a new statistical method of analyzing the microarray data. With this improved analysis, the group found 24 genes that behaved differently in patients who suffered radiation toxicity.

When Chu and his colleagues tested the patients' blood samples for these 24 genes, they identified nine of the 14 people with severe reactions. Of the remaining five patients, two were later found to have been treated with new approaches that carried high risks for toxicity. That left only three of 14 patients who the test failed to identify. Most important, the test did not mistakenly pinpoint any of the other patients.

Knowing which patients may have severe radiation toxicity could make treatment decisions easier. For cancers of the breast or prostate, Chu said surgical options can be as effective as radiation. "If you knew one of the options carried a big risk, that might alter your decision," he said.

For other cancer patients, radiation may be the best treatment. However, Chu added that patients at risk for high toxicity may also have cancers that die in response to much lower radiation doses. In such cases, radiation - though at greatly reduced doses - may still be an optio

Contact: Amy Adams
Stanford University Medical Center

Page: 1 2 3

Related medicine news :

1. Blood pressure treatment could cut risk of strokes and heart attacks
2. Blood protein predicts risk of heart attack
3. Blood transplants may be more harmful than bone marrow transplants in pediatric leukemia patients
4. Blood pressure drugs may slow deterioration of Alzheimers
5. Blood pressure control poor in elderly, says Northwestern researcher
6. Blood pressure for children and adolescents on the rise
7. Blood pressure drug helps delay ischemic brain damage in stroke patients
8. Blood test for liver cancer risk
9. Blood-forming stem cells fail to repair heart muscle in Stanford study
10. Blood test heralds speedy stroke diagnoses
11. Blood pressure may predict recurrent cardiovascular events in women

Post Your Comments:

(Date:8/31/2020)... ... August 31, 2020 , ... Colorado ... through high-quality, career-relevant, and affordable online education – is proud to announce its ... Among the first of its kind in the nation, the 60-credit hour program ...
(Date:8/31/2020)... Ga. (PRWEB) , ... August 31, 2020 , ... The pandemic and topsy-turvy economic outlook ... examine our budgets and look for ways to trim the fat from our monthly expenses ... your finances, but it’s also important that you have a financial safety net in place ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... In an ... West Loop is donating 10 percent of each hotel room booked with a ... Charities® of Chicagoland & Northwest Indiana (RMHC-CNI) , effective immediately. Donations will be ...
(Date:8/31/2020)... ... 31, 2020 , ... Bonde Innovations, LLC, a venture-backed developer ... failure, today announced that the company has been awarded a Phase 1 Small ... Heart, Lung, and Blood Institute of the National Institutes of Health (NIH). The ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ernst & Young LLP ... an Entrepreneur Of The Year® 2020 Florida Award finalist. Now in its 34th ... deliver innovation, growth and prosperity as they build and sustain successful businesses that ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... August 31, 2020 , ... ... technologies, today announced that they have invested $400,000 in PopBase, one of two ... collaboration with the Global Wellness Institute (GWI). , The competition was part ...
(Date:8/28/2020)... ... August 28, 2020 , ... Dr. Mark Surrey ... endoscopic surgeon and serves as a clinical professor in the Department of OBGYN at ... American Laparoscopy Society & Pacific Coast Reproductive Society and is a Clinical Director of ...
(Date:8/27/2020)... CHAPEL HILL, N.C. (PRWEB) , ... August 27, 2020 , ... ... Jensen, professional football player and sleep apnea patient, is the company’s new spokesperson. , ... on the football field. So, when I found the Bleep DreamPort it was a ...
Breaking Medicine Technology:
Cached News: