Bone loss prevention drug showing promise in advanced prostate cancer

Oral sodium clodronate may slow the development of symptomatic bone metastases and reduce the risk of death in men with advanced prostate cancer, according to a randomized controlled trial in the September 3 issue of the Journal of the National Cancer Institute.

Prostate cancer spreads most commonly to the bone, and bone metastases affect at least 85% of men with advanced prostate cancer. Bisphosphonates, including sodium clodronate, reduce bone loss. In the early 1990s, researchers in the United Kingdom initiated two phase III trials to examine the benefit of bisphosphonates in men with advanced prostate cancer. The results of one of these trials is now being reported.

David P. Dearnaley, M.D., of the Institute of Cancer Research and Royal Marsden Hospital in Sutton, United Kingdom; Matthew R. Sydes, M.Sc., of the Medical Research Council Clinical Trials Unit in London; and their colleagues randomly assigned 311 men who were starting or responding to hormone therapy for bone metastases to receive either oral sodium clodronate or a placebo for up to 3 years.

After approximately 5 years of follow up, men in the active treatment group had a 21% reduction in the risk of symptomatic bone progression and a 20% reduction in the risk of death, compared with men in the placebo group. However, these findings were not statistically significant. The authors note several limitations to the study, such as the small population size and the use of an oral rather than an intravenous bisphosphonate. Oral bisphosphonates are poorly absorbed by the body.

Patients in the sodium clodronate group did have a statistically significant 29% increase in the time before their performance status deteriorated. However, men who received sodium clodronate had a 71% greater risk of side effects. These effects were reversed when the drug dose was modified. A subgroup analysis suggested that clodronate might be more effective in men with more recently diagn

Contact: Linda Wang
Journal of the National Cancer Institute

Page: 1 2

Related medicine news :

1. International breast cancer prevention study launches in the United States and Canada
2. Cavity prevention tips for pre-school age children
3. HIV and ID doctors oppose ideologically driven STI prevention policies
4. School-based smoking prevention programs ineffective
5. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
6. Mount Sinai stroke prevention trial published in JAMA
7. New stroke-prevention drug unlikely to be cost-effective except in patients at high risk of bleeding
8. Association publishes blueprint to strengthen stroke care from prevention through recovery
9. Medical meeting to feature research findings and disease prevention and health promotion sessions
10. Beliefs may hinder HIV prevention among African-Americans
11. Business/govt address health care costs and prevention

Post Your Comments:

(Date:8/31/2020)... ... ... economic outlook continues to put financial strain on many of us, so it just makes ... monthly expenses and put more into savings, if possible. , “That’s a great way to ... in place in case something were to happen to you,” says Lee Duncan, CMO & ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... intended to improve outcomes for patients with advanced heart failure, today announced that ... grant in the amount of $555,358 from the National Heart, Lung, and Blood ...
(Date:8/28/2020)... Calif. (PRWEB) , ... August 28, 2020 , ... ... cover a one-year subscription to a customized Lighthouse Health & Wellness mobile app ... support of this project. Motorola Solutions Foundation awards grants each year to organizations, ...
(Date:8/28/2020)... ANGELES (PRWEB) , ... August 28, 2020 , ... ... on international observations that strongly suggest that obese individuals are at an increased ... people are any more likely to catch COVID-19; however, because the same organ ...
(Date:8/26/2020)... ... August 26, 2020 , ... ... at the upcoming Global Inclusion Online Forum, leading a session entitled, “A CEO ... online event of this magnitude designed to bring together the world’s leading diversity ...
Breaking Medicine News(10 mins):
(Date:9/2/2020)... ... September 02, 2020 , ... U.S. Dermatology Partners is ... Dr. Lee will work at Bethesda Dermatopathology Lab. , Jonathan Lee, MD ... University of California, Berkley. He went on to receive his M.D. with Honors from ...
(Date:9/1/2020)... ... 01, 2020 , ... Breast and ovarian cancers are common diseases that affect ... breast cancers (about 7,500 women per year) and 10% of ovarian cancers (about 2,000 ... Both genes are detectable in the Women’s Excellence Genetic Testing Program. , Dr. Jonathan ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... advisory guide, has named Cloudticity a Gold winner in the 15th Annual 2020 ... peer recogniti o ns from Network Products Guide honoring achievements of ...
Breaking Medicine Technology:
Cached News: