HOME >> MEDICINE >> NEWS
Bone marrow stem cells build new circulation to lungs

Orlando, Fla., Nov. 10 A bone marrow stem cell transplant restored circulation to injured blood vessels in animals with pulmonary hypertension, according to a study presented today at the American Heart Associations Scientific Sessions 2003.

This is a novel and exciting approach, said Duncan Stewart, M.D., professor and director of cardiology at the University of Toronto and head of cardiology at St. Michaels Hospital. Pulmonary arterial hypertension (PAH) is abnormally high blood pressure in the arteries between the heart and lungs. It is a progressive disease that can affect the arterioles and capillaries that supply blood to the lungs.

PAH reduces the hearts ability to pump blood through the lungs and gradually leads to heart failure. Today, we can achieve some improvement with drugs, but the treatment is palliative and can only delay death, Stewart said.

Restoring blood flow to the lungs with a stem cell transplant in the pulmonary vessels may hold promise as a new treatment for PAH, Stewart said.

His team used endothelial progenitor cells. Endothelial cells form a thin lining in blood vessels, providing an interface between the vessel and blood. This lining, called the endothelium, regulates a host of basic processes, such as blood clotting and blood pressure.

Our results show that endothelial progenitor cells from the bone marrow circulate in the bloodstream. We can use them to form new blood vessels or repair damaged ones, Stewart said. Stewart and co-investigator Yidan Zhao, M.D., a research associate at the University of Toronto and St. Michaels Hospital, removed vascular progenitor cells from rats bone marrow. The cells were cultured for five days, then injected into the pulmonary circulation of rats with PAH. A second group of rats with PAH received skin fibroblasts (cells), while a third group, which did not have PAH, were used as controls.

Right ventricular systolic blood pressur
'"/>

Contact: Carole Bullock
carole.bullock@heart.org
214-706-1279
American Heart Association
10-Nov-2003


Page: 1 2

Related medicine news :

1. Bone marrow fat may indicate bone weakening
2. Transplanted bone marrow cells reduce liver fibrosis in mice
3. New marrow transplant method developed at Stanford may eliminate fatal side effects
4. New research shows stomach (gastric) cancer originates from bone marrow derived stem cells
5. Blood transplants may be more harmful than bone marrow transplants in pediatric leukemia patients
6. Early signs that adult bone-marrow stem cells could regenerate brain tissue
7. Embryonic stem cells induced to develop into bone marrow and blood cells
8. An alternative to bone-marrow donation
9. Database on blood and marrow stem cell transplants now available online
10. Hormone released by bone marrow cells may hasten recovery from brain injury
11. Bone marrowderived stem cells active in pulmonary fibrosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2016)... ... , ... Hidden Cypress in Sun City is the place to be on March 3rd to ... Weniger will be hosting this educational seminar from 5:30 p.m. – 7:00 p.m. Exciting ... pricing on offers. In addition, prizes will be given away and light refreshments will be ...
(Date:2/13/2016)... ... February 13, 2016 , ... The producers of Enterprises TV are ... The increasingly modern world of instantaneous consumption proves very convenient for businesses. With new ... oil and coal, which pollutes our air, water, and soil. It can also threaten ...
(Date:2/13/2016)... ... February 13, 2016 , ... DDi , a ... Providers list for its expertise in eClinical Solutions. DDi has built its solution ... technology needs of global clients. DDi provides smarter technology for Clinical Development, Regulatory ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... to funding innovative lymphoma research and serving the lymphoma community through a comprehensive ... members of South Florida’s philanthropic community at its 10th anniversary Fashion Luncheon on ...
(Date:2/12/2016)... California (PRWEB) , ... February 12, 2016 , ... Coco ... their participation in Red Carpet Events LA GRAMMY’s Style Lounge Event. Coco Libre will ... way to stay hydrated before the big event. The invitation-only gifting suite, held this ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Feb. 12, 2016  Eli Lilly and Company (NYSE: ... the Alimta® (pemetrexed disodium) vitamin regimen patent would not presently ... France , Italy ... the product only with dextrose solution.  ... UK Court of Appeal held that Lilly,s patent would be ...
(Date:2/12/2016)... 12 2016  OMS Supply, a large provider of ... announced today the recent launching of their new company ... of features that enhance the user experience and enable ... --> --> Despite ... company that started in early 2016, they have already ...
(Date:2/12/2016)... LOUISVILLE, Ky. , Feb. 12, 2016 ... it has completed a $47.1 million Series ... investors Cormorant Asset Management, Hillhouse Capital Group ... investors Morningside Venture Investments, AJU IB Investment, ... will be used to further advance clinical ...
Breaking Medicine Technology:
Cached News: