Bone marrow stem cells build new circulation to lungs

Orlando, Fla., Nov. 10 A bone marrow stem cell transplant restored circulation to injured blood vessels in animals with pulmonary hypertension, according to a study presented today at the American Heart Associations Scientific Sessions 2003.

This is a novel and exciting approach, said Duncan Stewart, M.D., professor and director of cardiology at the University of Toronto and head of cardiology at St. Michaels Hospital. Pulmonary arterial hypertension (PAH) is abnormally high blood pressure in the arteries between the heart and lungs. It is a progressive disease that can affect the arterioles and capillaries that supply blood to the lungs.

PAH reduces the hearts ability to pump blood through the lungs and gradually leads to heart failure. Today, we can achieve some improvement with drugs, but the treatment is palliative and can only delay death, Stewart said.

Restoring blood flow to the lungs with a stem cell transplant in the pulmonary vessels may hold promise as a new treatment for PAH, Stewart said.

His team used endothelial progenitor cells. Endothelial cells form a thin lining in blood vessels, providing an interface between the vessel and blood. This lining, called the endothelium, regulates a host of basic processes, such as blood clotting and blood pressure.

Our results show that endothelial progenitor cells from the bone marrow circulate in the bloodstream. We can use them to form new blood vessels or repair damaged ones, Stewart said. Stewart and co-investigator Yidan Zhao, M.D., a research associate at the University of Toronto and St. Michaels Hospital, removed vascular progenitor cells from rats bone marrow. The cells were cultured for five days, then injected into the pulmonary circulation of rats with PAH. A second group of rats with PAH received skin fibroblasts (cells), while a third group, which did not have PAH, were used as controls.

Right ventricular systolic blood pressur

Contact: Carole Bullock
American Heart Association

Page: 1 2

Related medicine news :

1. Bone marrow fat may indicate bone weakening
2. Transplanted bone marrow cells reduce liver fibrosis in mice
3. New marrow transplant method developed at Stanford may eliminate fatal side effects
4. New research shows stomach (gastric) cancer originates from bone marrow derived stem cells
5. Blood transplants may be more harmful than bone marrow transplants in pediatric leukemia patients
6. Early signs that adult bone-marrow stem cells could regenerate brain tissue
7. Embryonic stem cells induced to develop into bone marrow and blood cells
8. An alternative to bone-marrow donation
9. Database on blood and marrow stem cell transplants now available online
10. Hormone released by bone marrow cells may hasten recovery from brain injury
11. Bone marrowderived stem cells active in pulmonary fibrosis

Post Your Comments:

(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... , ... June 24, 2016 , ... June 19, 2016 ... dangers associated with chronic pain and the benefits of holistic treatments, Serenity Recovery ... are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 , , , ... 7, 2016 , , , , LOCATION: , , , ... , , , EXPERT PANELISTS:  , , , Frost & Sullivan,s ... Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program ... global pharmaceutical industry is witnessing an exceptional era. Several new demand ...
(Date:6/23/2016)... 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered ... Latin America . ... ... ... ...
(Date:6/23/2016)... June 23, 2016  Guerbet announced today that it ... Supplier Horizon Award . One of 12 ... recognized for its support of Premier members through exceptional ... excellence, and commitment to lower costs. ... recognition of our outstanding customer service from Premier," says ...
Breaking Medicine Technology:
Cached News: