HOME >> MEDICINE >> NEWS
Bone marrow stem cells build new circulation to lungs

Orlando, Fla., Nov. 10 A bone marrow stem cell transplant restored circulation to injured blood vessels in animals with pulmonary hypertension, according to a study presented today at the American Heart Associations Scientific Sessions 2003.

This is a novel and exciting approach, said Duncan Stewart, M.D., professor and director of cardiology at the University of Toronto and head of cardiology at St. Michaels Hospital. Pulmonary arterial hypertension (PAH) is abnormally high blood pressure in the arteries between the heart and lungs. It is a progressive disease that can affect the arterioles and capillaries that supply blood to the lungs.

PAH reduces the hearts ability to pump blood through the lungs and gradually leads to heart failure. Today, we can achieve some improvement with drugs, but the treatment is palliative and can only delay death, Stewart said.

Restoring blood flow to the lungs with a stem cell transplant in the pulmonary vessels may hold promise as a new treatment for PAH, Stewart said.

His team used endothelial progenitor cells. Endothelial cells form a thin lining in blood vessels, providing an interface between the vessel and blood. This lining, called the endothelium, regulates a host of basic processes, such as blood clotting and blood pressure.

Our results show that endothelial progenitor cells from the bone marrow circulate in the bloodstream. We can use them to form new blood vessels or repair damaged ones, Stewart said. Stewart and co-investigator Yidan Zhao, M.D., a research associate at the University of Toronto and St. Michaels Hospital, removed vascular progenitor cells from rats bone marrow. The cells were cultured for five days, then injected into the pulmonary circulation of rats with PAH. A second group of rats with PAH received skin fibroblasts (cells), while a third group, which did not have PAH, were used as controls.

Right ventricular systolic blood pressur
'"/>

Contact: Carole Bullock
carole.bullock@heart.org
214-706-1279
American Heart Association
10-Nov-2003


Page: 1 2

Related medicine news :

1. Bone marrow fat may indicate bone weakening
2. Transplanted bone marrow cells reduce liver fibrosis in mice
3. New marrow transplant method developed at Stanford may eliminate fatal side effects
4. New research shows stomach (gastric) cancer originates from bone marrow derived stem cells
5. Blood transplants may be more harmful than bone marrow transplants in pediatric leukemia patients
6. Early signs that adult bone-marrow stem cells could regenerate brain tissue
7. Embryonic stem cells induced to develop into bone marrow and blood cells
8. An alternative to bone-marrow donation
9. Database on blood and marrow stem cell transplants now available online
10. Hormone released by bone marrow cells may hasten recovery from brain injury
11. Bone marrowderived stem cells active in pulmonary fibrosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2016)... ... May 28, 2016 , ... After a year and a half of planning the ... extraordinary event. The Multiple Pathways of Recovery Conference was held May 2 -4, 2016 ... and the United Kingdom came together to explore the many pathways individuals use to get ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... W.S. ... products, announced today that it has been recognized as one of the best small ... Badger was named as one of nine small businesses providing progressive benefits to new ...
(Date:5/27/2016)... ... May 27, 2016 , ... In response ... many who are unaware of the plight of aphasia. In collaboration with the ... “Stroke Awareness” campaign. , The link between stroke and aphasia is relatively unknown, ...
(Date:5/27/2016)... ... May 27, 2016 , ... With a team of ... food industries. Aside from its GMP accreditation, Validation Center is also a registered ... products, services and staff. , Validation Center is ISO17025 accredited and only offers ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... clinical outcomes, hosted members and suppliers for its inaugural Member Conference at the ... their mission of elevating the operational health of America’s healthcare providers. , The ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... CAESAREA, Israel , May 27, 2016 ... developer of the Dario™ Diabetes Management Tool, today announced that ... present at the Marcum MicroCap Conference being held June 1-2 ... LD Micro Invitational, being held June 7-9 in ... Mr. Ben-David will discuss recent corporate and operational milestones, including ...
(Date:5/27/2016)... -- Hutchison China MediTech (Chi-Med) (HCM) ... highly lucrative global oncology and immunology markets. HCM ... or best-in-class tyrosine kinase inhibitor (TKI) drugs, some ... HCM,s profitable Chinese healthcare business continues to benefit ... of the mid-to-late-stage pipeline during 2016-17 (including US ...
(Date:5/27/2016)... May 27, 2016 Amarantus BioScience Holdings, ... developing products for Regenerative Medicine, Neurology and Orphan Diseases, today announced ... presenting at two upcoming investor conferences: SeeThru Equity ... Avenue, New York City , NY ... Marcum MicroCap Conference   Where: Grand Hyatt Hotel, ...
Breaking Medicine Technology:
Cached News: