HOME >> MEDICINE >> NEWS
Bone marrow stem cells build new circulation to lungs

Orlando, Fla., Nov. 10 A bone marrow stem cell transplant restored circulation to injured blood vessels in animals with pulmonary hypertension, according to a study presented today at the American Heart Associations Scientific Sessions 2003.

This is a novel and exciting approach, said Duncan Stewart, M.D., professor and director of cardiology at the University of Toronto and head of cardiology at St. Michaels Hospital. Pulmonary arterial hypertension (PAH) is abnormally high blood pressure in the arteries between the heart and lungs. It is a progressive disease that can affect the arterioles and capillaries that supply blood to the lungs.

PAH reduces the hearts ability to pump blood through the lungs and gradually leads to heart failure. Today, we can achieve some improvement with drugs, but the treatment is palliative and can only delay death, Stewart said.

Restoring blood flow to the lungs with a stem cell transplant in the pulmonary vessels may hold promise as a new treatment for PAH, Stewart said.

His team used endothelial progenitor cells. Endothelial cells form a thin lining in blood vessels, providing an interface between the vessel and blood. This lining, called the endothelium, regulates a host of basic processes, such as blood clotting and blood pressure.

Our results show that endothelial progenitor cells from the bone marrow circulate in the bloodstream. We can use them to form new blood vessels or repair damaged ones, Stewart said. Stewart and co-investigator Yidan Zhao, M.D., a research associate at the University of Toronto and St. Michaels Hospital, removed vascular progenitor cells from rats bone marrow. The cells were cultured for five days, then injected into the pulmonary circulation of rats with PAH. A second group of rats with PAH received skin fibroblasts (cells), while a third group, which did not have PAH, were used as controls.

Right ventricular systolic blood pressur
'"/>

Contact: Carole Bullock
carole.bullock@heart.org
214-706-1279
American Heart Association
10-Nov-2003


Page: 1 2

Related medicine news :

1. Bone marrow fat may indicate bone weakening
2. Transplanted bone marrow cells reduce liver fibrosis in mice
3. New marrow transplant method developed at Stanford may eliminate fatal side effects
4. New research shows stomach (gastric) cancer originates from bone marrow derived stem cells
5. Blood transplants may be more harmful than bone marrow transplants in pediatric leukemia patients
6. Early signs that adult bone-marrow stem cells could regenerate brain tissue
7. Embryonic stem cells induced to develop into bone marrow and blood cells
8. An alternative to bone-marrow donation
9. Database on blood and marrow stem cell transplants now available online
10. Hormone released by bone marrow cells may hasten recovery from brain injury
11. Bone marrowderived stem cells active in pulmonary fibrosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2017)... (PRWEB) , ... April 25, ... ... based in Newport Beach, California, committed to raising awareness for Duchenne muscular ... results from its randomized CAP-1002 (cardiosphere-derived cells) Phase I/II HOPE clinical trial ...
(Date:4/25/2017)... ... April 25, 2017 , ... Lake Park Dental is ... using Invisalign® in Lutz, FL. With the help of this highly-effective, yet ... with fewer potential complications, more discretion and less pain. , Drs. Sarah Jockin, ...
(Date:4/25/2017)... MN (PRWEB) , ... April 25, 2017 , ... Buyers ... and recreational users to dispensaries and head shops –can’t help but be heartened by ... for the tell-tale cannabis odor aptly described as “skunk smell.” At last they ...
(Date:4/25/2017)... ... April 25, 2017 , ... Vetoquinol USA® , a ... UCII, part of the EQUISTRO line, at this week’s Rolex Kentucky Three-Day Event ... the immunologic level. , The scientifically-developed Flexadin UCII supports the body’s normal repair ...
(Date:4/24/2017)... ... April 24, 2017 , ... The Santana Telehealth Project was honored with the ... the American Telemedicine Association’s annual conference, on April 23 in Orlando, FL. , “I ... improve the lives of the poor and underserved in other parts of the world,” ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017  IRIDEX Corporation (Nasdaq: IRIX ) ... the first quarter 2017 after the close of trading ... will host a corresponding conference call beginning at 2:30 ... interested in listening to the conference call may do ... (703) 326-3030 for international callers, using conference ID: 92158987.  ...
(Date:4/19/2017)... DIEGO , April 19, 2017  Sorrento ... an antibody-centric, clinical-stage biopharmaceutical company developing new treatments ... announced the closing of its previously announced underwritten ... stock at a public offering price of $2.00 ... and estimated offering expenses payable by Sorrento.  The ...
(Date:4/18/2017)... April 18, 2017  Cardinal Health (NYSE: ... fiscal 2017 earnings per share (EPS) guidance and providing ... is in conjunction with this morning,s announcement of the ... and Nutritional Insufficiency businesses. Cardinal Health now ... will be at the bottom of its previous guidance ...
Breaking Medicine Technology:
Cached News: