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Bone microarchitecture can significantly deteriorate in one year

for a given therapy.

In the study reported today, iliac crest biopsies collected from patients were analyzed by 3D microcomputed tomography for microarchitecture parameters, including bone volume, trabecular number, and trabecular separation. The data showed significant deterioration in the placebo group for these three parameters at one year versus baseline: bone volume decreased 20.3 per cent (p= 0.032), trabecular number decreased 13.5 per cent (p=0.025) and trabecular separation increased 13.1 per cent (p=0.014). In the Actonel group over the same period there was no significant deterioration versus baseline in any of the microarchitecture parameters analyzed.

About Osteoporosis
According to the International Osteoporosis Foundation, an estimated 200 million women suffer from osteoporosis worldwide. In the United States, the National Osteoporosis Foundation estimates that the overall lifetime risk of experiencing a fracture due to osteoporosis for women over the age of 50 is 40 per cent or two out of every five. Postmenopausal osteoporosis is the most common form of osteoporosis

About Actonel (risedronate sodium tablets)
Actonel is co-developed and co-marketed by Procter & Gamble Pharmaceuticals and Aventis Pharmaceuticals. Actonel 35 mg once-a-week and Actonel 5 mg daily are indicated for the prevention and treatment of osteoporosis in postmenopausal women. Actonel 5 mg daily is also indicated for the prevention and treatment of glucocorticoid-induced osteoporosis (GIO) in men and women either initiating or continuing systemic glucocorticoid treatment (? 7.5 mg/d prednisone or equivalent) for chronic diseases.

In clinical trials, Actonel was generally well tolerated. Actonel is contraindicated in patients with hypocalcemia, known hypersensitivity to any component of this product, or inability to stand or sit upright for at least 30 minutes. Hypocalcemia and other disturban
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Contact: Julie McQuain
jmprmedia@aol.com
212-477-0472
JMPR Associates, Inc.
21-Jun-2002


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