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Bone microarchitecture can significantly deteriorate in one year

ces of bone and mineral metabolism should be effectively treated before starting Actonel therapy. Actonel is not recommended for use in patients with severe renal impairment (creatinine clearance < 30 mL/min).

Bisphosphonates may cause upper gastrointestinal disorders such as dysphagia, esophagitis and esophageal or gastric ulcer. Patients should pay particular attention to the dosing instructions, as failure to take the drug according to instructions may compromise clinical benefits and may increase the risk of adverse events.

In clinical trials, the overall incidence of adverse events with Actonel 5 mg daily was comparable to placebo. The most commonly reported adverse events regardless of causality were infection (primarily upper respiratory, placebo 29.7 per cent vs. Actonel 5 mg 29.9 per cent), back pain (23.6 per cent vs. 26.1 per cent), and arthralgia (21.1 per cent vs. 23.7 per cent).

In a one-year clinical trial comparing Actonel 35 mg once-a-week and Actonel 5 mg daily, the overall incidence of adverse events with the two dosing regimens was similar. The most commonly reported adverse events regardless of causality were infection (Actonel 35 mg 20.6 per cent vs. Actonel 5 mg 19.0 per cent), arthralgia (14.2 per cent vs. 11.5 per cent) and constipation (12.2 per cent vs. 12.5 per cent).


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Contact: Julie McQuain
jmprmedia@aol.com
212-477-0472
JMPR Associates, Inc.
21-Jun-2002


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