HOME >> MEDICINE >> NEWS
Brain activity, including memory-processing, changes in Tourette syndrome

St. Louis, April 5, 2004 -- Scientists have known for years that abnormal activity involving a brain chemical called dopamine is somehow connected to the movements and vocalizations, or tics, associated with Tourette syndrome. Now neuroscience researchers at Washington University School of Medicine in St. Louis have found brain activity in these patients is abnormal during memory tasks, as well.

The researchers also found that giving Tourette syndrome patients the drug levodopa, which is used to treat abnormal dopamine activity in conditions such as Parkinson's disease, normalized brain activity during the memory tasks.

"We've observed in the living brain a dopamine-sensitive abnormality in people with tics. That's been hypothesized for 40 years, but this is the first time it's been demonstrated," says principal investigator Kevin J. Black, M.D., assistant professor of psychiatry, neurology and radiology and staff physician at Barnes-Jewish Hospital. "We actually have a direct demonstration of abnormal brain activation in people with Tourette syndrome that is corrected when they are given a dopamine-type medicine."

The study is published online and will appear in the May issue of the journal Biological Psychiatry.

Using functional magnetic resonance imaging (fMRI), the researchers compared eight adults with Tourette syndrome to 10 age- and gender-matched individuals without tics. Brain scans were taken while participants performed a memory task that involved remembering and identifying letters on a computer screen. The task measures working memory, a type of short-term memory that involves concentration on several things at once.

"We chose to look at the brain's response to a working memory task because past research has shown that working memory could be affected by dopamine levels in the brain," says first author Tamara Hershey, Ph.D., assistant professor of psychiatry and neurology at the School of Medicine. "We a
'"/>

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine
5-Apr-2004


Page: 1 2 3

Related medicine news :

1. Brain activity prior to treatment flags vulnerability to antidepressant side effects
2. Brain imaging study may hold clues to onset of schizophrenia in people at high risk
3. Brain imaging reveals secrets of love, fear and betrayal
4. Brain imaging studies investigate pain reduction by hypnosis
5. Brain tumor with dismal prognosis in infants can be cured in older children
6. Brain-scanning technologies need standards, according to Stanford researcher
7. Brain activity of men and women during hostile or impulsive acts differs less on nicotine
8. Brain synapse formation linked to proteins, Stanford study finds
9. Brain tumor treatment can vary greatly, according to new JAMA study
10. Brain region identified that controls collecting behavior
11. Brain imaging reveals new language circuits

Post Your Comments:
(Date:7/29/2015)... ... 2015 , ... Avatar Solutions has received official approval from CMS to administer ... CAHPS for PQRS Survey collects information about patients’ experiences of care within ... participate or they will receive a 2% penalty in 2017. At this point in ...
(Date:7/29/2015)... ... July 29, 2015 , ... This past week, CARE Surrogacy Center Mexico ... treasured member of the CARE extended family. , By shedding light on positive ... across the globe gain a newfound perspective on surrogacy in Mexico. The center wholeheartedly ...
(Date:7/29/2015)... ... July 29, 2015 , ... Andrzej Klos, M.D., has been reviewed and ... for nearly 38 years, is motivated each and every day by his sincere desire ... shine alongside his many awards and accolades, which include multiple listings in many highly ...
(Date:7/29/2015)... ... 2015 , ... Potomac Pilates, an elite Washington, D.C. metro area-based Pilates studio, ... ® by Potomac Pilates. On Thursday, July 30, Potomac Pilates will unveil its ... Potomac Pilates will continue to offer the same classes and personal experiences their clients ...
(Date:7/29/2015)... ... , ... Ticket Down is a reliable source of authentic tickets for the ... , The international soccer schedule of matches played on American soil continues to grow ... of the world’s greatest teams, Brazil, will travel to North America to compete with ...
Breaking Medicine News(10 mins):Health News:Avatar Solutions Approved to Administer CAHPS for Physician Quality Reporting System (PQRS) 2Health News:Avatar Solutions Approved to Administer CAHPS for Physician Quality Reporting System (PQRS) 3Health News:Heartfelt Interview Shows Extraordinary Impact of CARE Surrogacy Center Mexico 2Health News:Heartfelt Interview Shows Extraordinary Impact of CARE Surrogacy Center Mexico 3Health News:NJ Top Docs Presents, Dr. Andrzej Klos of Carepoint Health Pediatrics! 2Health News:NJ Top Docs Presents, Dr. Andrzej Klos of Carepoint Health Pediatrics! 3Health News:Same Great Pilates Studio, New Brand - Rock the Reformer 2Health News:Cheap USA vs. Brazil Tickets at Gillette Stadium: Ticket Down Cuts Presale Ticket Prices for Brazil vs. USA Men's National Soccer Team (USMNT) at Gillette Stadium 2Health News:Cheap USA vs. Brazil Tickets at Gillette Stadium: Ticket Down Cuts Presale Ticket Prices for Brazil vs. USA Men's National Soccer Team (USMNT) at Gillette Stadium 3
(Date:7/29/2015)...  Nektar Therapeutics (Nasdaq: NKTR ) will announce its ... on Wednesday, August 5, 2015, after the close of U.S.-based ... officer, will host a conference call to review the results ... (PT). The press release and a live ... a link that is posted on the home page and ...
(Date:7/29/2015)... CAMBRIDGE, Mass. , July 29, ... ), the leader in RNA-targeted therapeutics, and Akcea ... The New England Journal of Medicine ... study evaluating volanesorsen (formerly ISIS-APOCIII Rx ) in ... This publication follows the December 2014 publication in ...
(Date:7/29/2015)... PALO ALTO, Calif. , July 29, 2015 /PRNewswire/ ... announced it has, through one of its European subsidiaries, ... -based supplier of components and subsystems for X-ray ... will pay approximately €50 million in cash ... in August. Claymount is one of ...
Breaking Medicine Technology:Nektar to Announce Financial Results for the Second Quarter 2015 on Wednesday, August 5, 2015, After Close of U.S.-Based Financial Markets 2Nektar to Announce Financial Results for the Second Quarter 2015 on Wednesday, August 5, 2015, After Close of U.S.-Based Financial Markets 3Positive Clinical Data From Volanesorsen Published in the New England Journal of Medicine 2Positive Clinical Data From Volanesorsen Published in the New England Journal of Medicine 3Positive Clinical Data From Volanesorsen Published in the New England Journal of Medicine 4Positive Clinical Data From Volanesorsen Published in the New England Journal of Medicine 5Positive Clinical Data From Volanesorsen Published in the New England Journal of Medicine 6Positive Clinical Data From Volanesorsen Published in the New England Journal of Medicine 7Varian Medical Systems Acquiring Claymount to Expand Imaging Components Portfolio 2Varian Medical Systems Acquiring Claymount to Expand Imaging Components Portfolio 3Varian Medical Systems Acquiring Claymount to Expand Imaging Components Portfolio 4
Cached News: