HOME >> MEDICINE >> NEWS
Brain-imaging study offers clues to inhalant abuse

UPTON, NY -- Inhalant abuse, also known as "huffing," is a rapidly growing health problem, particularly among young people. However, little is known about how inhaled chemicals affect the brain and body. Now, scientists at the U.S. Department of Energy's Brookhaven National Laboratory -- inspired by schoolchildren who wanted to know more about huffing -- have produced the first-ever images showing what parts of the brain and body are most affected by toluene, a commonly inhaled solvent. The study, which was performed in baboons and mice, appears in the April 26 issue of the journal Life Sciences (available online April 15).

The images show that toluene moves into the brain rapidly and initially affects the same brain regions as cocaine and other abused drugs. Then, toluene spreads more generally to the entire brain before clearing the body rapidly via the kidneys. "This affinity for brain regions associated with reward and pleasure, as well as the quick uptake and clearance, may help to explain why inhalants are so commonly abused," said lead author Madina Gerasimov, a Brookhaven chemist.

"For the first time, we have shown in living animals where the most commonly used solvent goes in the brain and the whole body," said Brookhaven neuroanatomist Stephen Dewey, a coauthor.

"This study was really born out of my going to elementary schools, where I've been giving talks about Brookhaven's addiction research since 1995," said Dewey. During his talks, children as young as fourth and fifth graders would sometimes ask him about huffing. "After about the third or fourth time someone asked me, I proposed that we develop a way to label and image solvents, which seem to be a 'gateway' drug of abuse for some young children," he said.

The team chose toluene because it is one of the most common industrial solvents, found in paints, glues, and other household products often abused by huffers. To label the toluene, Brookhaven chemists replaced some
'"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
15-Apr-2002


Page: 1 2 3

Related medicine news :

1. Brain-imaging study sheds more light on underlying cause of attention-deficit hyperactivity syndrome
2. Brain-imaging cap under study for space and Earth use
3. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
4. UMaine study looks at infants and chronic nighttime crying
5. Chronic pain treatments more effective when taken together, new study shows
6. UNC study: Most N.C. family practitioners engage in unrecognized community service
7. New study in Nature demonstrates protection against cell death during heart attack
8. UCSF study offers insight into human circadian rhythms
9. International breast cancer prevention study launches in the United States and Canada
10. UW study shows blacks and Latinos are more satisfied with physicians of the same race
11. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brain imaging study offers clues inhalant abuse

(Date:11/23/2014)... Wright & Schulte LLC recently filed ... West Virginia residents who allege that they developed thyroid ... to drinking C8 contaminated water released by the ... to the C8 complaints, the plaintiffs were exposed to ... in at least one of the six water districts ...
(Date:11/23/2014)... City, Utah (PRWEB) November 23, 2014 ... health insurance reimbursement for small businesses, announced their ... book, The End of Employer-Provided Health Insurance. ... insurance is the greatest financial risk facing most ... facing U.S. employers, small and large, when it ...
(Date:11/22/2014)... 23, 2014 A new AlignLife Chiropractic ... in the downtown Greenville area. Dr. Chelsea Sineath, owner ... decided to open her own clinic after working in ... the patients. , AlignLife believes that the body ... a focus on chiropractic care and rehabilitation to allow ...
(Date:11/22/2014)... PrettyTailor , an outstanding dress company, has recently ... can buy new dresses at its online shop now. ... , As a matter of fact, PrettyTailor specializes in ... four types of wedding outfits, including bridesmaid dresses, mother ... also provides a variety of occasion dresses, such as ...
(Date:11/22/2014)... A classic black prom dress will never ... dress suppliers, has unveiled its new items of black ... offered at a big discount, up to 70% off. People ... The new black prom dresses, made with the best materials, ... needs of all customers, the company provides these beautiful outfits ...
Breaking Medicine News(10 mins):Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 2Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 3Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 4Health News:Zane Benefits, Inc. Announces New Webinar on The End of Employer-Provided Health Insurance Now Available On-Demand! 2Health News:AlignLife of Downtown Greenville is Now Open and Accepting New Patients 2Health News:Customers Are Welcome to Shop at PrettyTailor.com 2Health News:New Black Prom Dresses from BellasDress.com 2
(Date:11/21/2014)... 2014  Tandem Diabetes Care ® , Inc. ... company and manufacturer of the t:slim ® ... a non-profit dedicated to improving diabetes therapy management ... increases diabetes data accessibility. This partnership will enable ... under development, to download and access data from ...
(Date:11/21/2014)... 2014   Rock Creek Pharmaceuticals, Inc., (NASDAQ: ... scheduled to present at the Biotech Showcase™ 2015 taking ... on January 12-14, 2015. Michael ... Creek Pharmaceuticals, will present preclinical and clinical data for ... anti-inflammatory pharmacological characteristics. Dr. Mullan will outline the Company,s ...
(Date:11/21/2014)... 21, 2014  Heated dialogue in recent months about ... cancer treatments to Gilead,s new hepatitis C drug Harvoni® ... world questioning what it means to put a price ... And while drug pricing is one of the ... both a general business and ethical standpoint – it ...
Breaking Medicine Technology:Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 3Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 2Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 3Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 4"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 2"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 3"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 4"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 5
Cached News: