HOME >> MEDICINE >> NEWS
Brain-imaging study offers clues to inhalant abuse

UPTON, NY -- Inhalant abuse, also known as "huffing," is a rapidly growing health problem, particularly among young people. However, little is known about how inhaled chemicals affect the brain and body. Now, scientists at the U.S. Department of Energy's Brookhaven National Laboratory -- inspired by schoolchildren who wanted to know more about huffing -- have produced the first-ever images showing what parts of the brain and body are most affected by toluene, a commonly inhaled solvent. The study, which was performed in baboons and mice, appears in the April 26 issue of the journal Life Sciences (available online April 15).

The images show that toluene moves into the brain rapidly and initially affects the same brain regions as cocaine and other abused drugs. Then, toluene spreads more generally to the entire brain before clearing the body rapidly via the kidneys. "This affinity for brain regions associated with reward and pleasure, as well as the quick uptake and clearance, may help to explain why inhalants are so commonly abused," said lead author Madina Gerasimov, a Brookhaven chemist.

"For the first time, we have shown in living animals where the most commonly used solvent goes in the brain and the whole body," said Brookhaven neuroanatomist Stephen Dewey, a coauthor.

"This study was really born out of my going to elementary schools, where I've been giving talks about Brookhaven's addiction research since 1995," said Dewey. During his talks, children as young as fourth and fifth graders would sometimes ask him about huffing. "After about the third or fourth time someone asked me, I proposed that we develop a way to label and image solvents, which seem to be a 'gateway' drug of abuse for some young children," he said.

The team chose toluene because it is one of the most common industrial solvents, found in paints, glues, and other household products often abused by huffers. To label the toluene, Brookhaven chemists replaced some
'"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
15-Apr-2002


Page: 1 2 3

Related medicine news :

1. Brain-imaging study sheds more light on underlying cause of attention-deficit hyperactivity syndrome
2. Brain-imaging cap under study for space and Earth use
3. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
4. UMaine study looks at infants and chronic nighttime crying
5. Chronic pain treatments more effective when taken together, new study shows
6. UNC study: Most N.C. family practitioners engage in unrecognized community service
7. New study in Nature demonstrates protection against cell death during heart attack
8. UCSF study offers insight into human circadian rhythms
9. International breast cancer prevention study launches in the United States and Canada
10. UW study shows blacks and Latinos are more satisfied with physicians of the same race
11. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brain imaging study offers clues inhalant abuse

(Date:8/1/2014)... Home Care Assistance of Cincinnati , a ... be recognized as a 2014 Best of Home Care Employer ... providers who rank in the top 50th percentile in one ... conducted by Home Care Pulse. , “The Best of ... best of the best!” says Home Care Pulse Founder and ...
(Date:8/1/2014)... Ticket Down is a reputable source for authentic ... Knoxville/Greenback, TN; Ingram Farms in Auburn/Opelika, AL; Cross Creek Place ... Luke Bryan is currently out on his summer “That’s My ... Bryan is responsible for one of the most popular country ... just because the summer is over doesn’t mean that when ...
(Date:8/1/2014)... of Bioengineering and Nanotechnology (IBN), Singapore General Hospital ... co-developed the first molecular test kit that can ... patients. This breakthrough was recently reported in ... , According to IBN Executive Director Professor ... molecular diagnostics and cancer research, we have developed ...
(Date:8/1/2014)... August 01, 2014 CapsCanada, a ... opening of a new K-CAPS® (HPMC capsules) manufacturing ... announced expansion plans last year while experiencing growing ... Martin, General Manager, “KCAPS® are currently sold in ... added that: “Compared to other HPMC capsules, K-CAPS® ...
(Date:8/1/2014)... Hills, CA (PRWEB) August 01, 2014 ... has found that carbohydrates may contribute to the ... genetically predisposed to the disease. The study was authored ... it, carbohydrates were found to cause intestinal cells to ... more susceptible to colorectal cancer. , “What’s interesting ...
Breaking Medicine News(10 mins):Health News:Cincinnati Senior Care Company Receives 2014 Best of Home Care® Employer of Choice Award 2Health News:Luke Bryan Tickets at Maple Lane Farms in Knoxville, Ingram Farms in Auburn, Cross Creek Place in Tallahassee & Whitehurst Cattle Farm in Gainesville Now Available 2Health News:Luke Bryan Tickets at Maple Lane Farms in Knoxville, Ingram Farms in Auburn, Cross Creek Place in Tallahassee & Whitehurst Cattle Farm in Gainesville Now Available 3Health News:Luke Bryan Tickets at Maple Lane Farms in Knoxville, Ingram Farms in Auburn, Cross Creek Place in Tallahassee & Whitehurst Cattle Farm in Gainesville Now Available 4Health News:Taking the guesswork out of cancer therapy 2Health News:Taking the guesswork out of cancer therapy 3Health News:Carbs May Contribute to Colon Cancer 2
(Date:7/31/2014)... 31, 2014  UBM Medica US announces that ... for oncologists, presents exclusive slide shows dealing with communication ... quality cancer care. Cancer Network, ... offers news, blogs, and podcasts about the latest clinical ... care: , End-of-life care is challenging for ...
(Date:7/31/2014)... 2014  Decision Resources Group is launching an extension ... to now include ChinaTrack; the new capabilities track the ... interactive dashboard providing detailed brand-level share tracking and analytics. ... level. Other key capabilities of the new ... addition to end-user surveys of healthcare facilities, ChinaTrack data ...
(Date:7/31/2014)... Lazarus Effect, a medical device company focused ... removal of blood clots, announced the closing of a ... EU commercialization of several approved Lazarus Effect devices, as ... Lazarus Cover™ in the United States ... the value of our novel, platform technology as well ...
Breaking Medicine Technology:Cancer Network Highlights Methods Oncologists Can Use to Improve Communication 2Cancer Network Highlights Methods Oncologists Can Use to Improve Communication 3Decision Resources Group Announces First Medical Device Account Targeting Tool in China 2Lazarus Effect Closes $5 Million Financing 2
Cached News: