HOME >> MEDICINE >> NEWS
Brain-imaging study offers clues to inhalant abuse

UPTON, NY -- Inhalant abuse, also known as "huffing," is a rapidly growing health problem, particularly among young people. However, little is known about how inhaled chemicals affect the brain and body. Now, scientists at the U.S. Department of Energy's Brookhaven National Laboratory -- inspired by schoolchildren who wanted to know more about huffing -- have produced the first-ever images showing what parts of the brain and body are most affected by toluene, a commonly inhaled solvent. The study, which was performed in baboons and mice, appears in the April 26 issue of the journal Life Sciences (available online April 15).

The images show that toluene moves into the brain rapidly and initially affects the same brain regions as cocaine and other abused drugs. Then, toluene spreads more generally to the entire brain before clearing the body rapidly via the kidneys. "This affinity for brain regions associated with reward and pleasure, as well as the quick uptake and clearance, may help to explain why inhalants are so commonly abused," said lead author Madina Gerasimov, a Brookhaven chemist.

"For the first time, we have shown in living animals where the most commonly used solvent goes in the brain and the whole body," said Brookhaven neuroanatomist Stephen Dewey, a coauthor.

"This study was really born out of my going to elementary schools, where I've been giving talks about Brookhaven's addiction research since 1995," said Dewey. During his talks, children as young as fourth and fifth graders would sometimes ask him about huffing. "After about the third or fourth time someone asked me, I proposed that we develop a way to label and image solvents, which seem to be a 'gateway' drug of abuse for some young children," he said.

The team chose toluene because it is one of the most common industrial solvents, found in paints, glues, and other household products often abused by huffers. To label the toluene, Brookhaven chemists replaced some
'"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
15-Apr-2002


Page: 1 2 3

Related medicine news :

1. Brain-imaging study sheds more light on underlying cause of attention-deficit hyperactivity syndrome
2. Brain-imaging cap under study for space and Earth use
3. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
4. UMaine study looks at infants and chronic nighttime crying
5. Chronic pain treatments more effective when taken together, new study shows
6. UNC study: Most N.C. family practitioners engage in unrecognized community service
7. New study in Nature demonstrates protection against cell death during heart attack
8. UCSF study offers insight into human circadian rhythms
9. International breast cancer prevention study launches in the United States and Canada
10. UW study shows blacks and Latinos are more satisfied with physicians of the same race
11. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brain imaging study offers clues inhalant abuse

(Date:2/28/2015)... Vegas, NV (PRWEB) February 28, 2015 My ... will be sending a team to Las Vegas, Nevada for ... Market Week is one of the leading consumer-goods tradeshows and ... vendors at this year’s event. My Shiney Hiney can be ... a fresh, modern design for the at-home personal hygiene brush ...
(Date:2/27/2015)... 27, 2015 Wireless Analytics, ... and one of the founders of the ... Bell Mobility within their CLEAN Platform™ (Communications Lifecycle ... Wireless Analytics’ newly developed Bell Mobility Data Loader ... Canadian wireless carrier’s business customers. , Wireless Analytics ...
(Date:2/27/2015)... Just a little over two years ago, ... Sjögren’s Syndrome after a new autoantibody associated with the ... of Buffalo and Immco Diagnostics, Inc. After the groundbreaking ... a new diagnostic test that would be ... Researchers aimed to develop a test that would more ...
(Date:2/27/2015)... On March 2-4, the Mesothelioma Applied ... Institute (NCI) will co-host the annual International Symposium ... Health (NIH), in Bethesda, Maryland. The event comprises ... professionals and scientists who specialize in mesothelioma, while ... including patients, their families, and caregivers. , The ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 Altec Products, ... as their Sage ERP Document Management Partner of the ... ERP, Sage CRM and other complimentary solutions for their ... worked side-by-side for many years to provide clients with ... applications. , “We are thrilled to recognize ADSS ...
Breaking Medicine News(10 mins):Health News:My Shiney Hiney® to Participate in ASD Market Week 2015 2Health News:Bell Mobility Gains Traction With Enterprises; Is Added to Wireless Analytics’ CLEAN Platform™ 2Health News:Bell Mobility Gains Traction With Enterprises; Is Added to Wireless Analytics’ CLEAN Platform™ 3Health News:Breakthrough Blood Test for Early Detection of Sjögren’s Syndrome Now Available 2Health News:Conference on Mesothelioma Co-Hosted with National Cancer Institute 2Health News:Conference on Mesothelioma Co-Hosted with National Cancer Institute 3Health News:Altec Announces 2014 Sage ERP Document Management Partner of the Year Award Recipient 2
(Date:2/27/2015)... Pa. , Feb. 27, 2015  In recognition ... ongoing commitment to the global bleeding disorders community, ... 2 million international units (IUs) of protein therapies to ... international not-for- profit organization which has worked to improve ... bleeding disorders. The donation supports the WFH,s Global Alliance ...
(Date:2/27/2015)... TEL-AVIV, Israel , February 27, 2015 ... Unternehmen baut sein bahnbrechendes Überwachungssystem für kongestive ... weiter aus -   ... Medical Technologies, die ein neuartiges Herzüberwachungssystem für ... gab heute bekannt, dass sie ein Finanzierungsvorhaben ...
(Date:2/27/2015)... YORK , Feb. 27, 2015 /PRNewswire/ ... are increasing in applications as their effectiveness ... firm Kalorama Information.  Kalorama Information says that ... is the most powerful tool in proteomic ... spec; MS) through its traditional techniques has ...
Breaking Medicine Technology:CSL Behring Continues Treatment Access Leadership by Donating Bleeding Disorder Protein Therapies IUs to World Federation of Hemophilia 2CSL Behring Continues Treatment Access Leadership by Donating Bleeding Disorder Protein Therapies IUs to World Federation of Hemophilia 3Vectorious Medical Technologies schließt Finanzierungsvorhaben über 5 Mio. USD ab 2Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 2Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 3
Cached News: