HOME >> MEDICINE >> NEWS
Brain-imaging study offers clues to inhalant abuse

of the compound's carbon atoms with a radioactive isotope, carbon-11. This radiolabeled toluene was then injected into the experimental animals. (The scientists used injection rather than inhalation as an administration route so that they would know precisely how much toluene the animals were given.)

The level of the radioisotope was then measured using a positron emission tomography (PET) camera, which picks up the radioactive signal, shows exactly where the toluene is located in the body, and tracks its location over time. Other tissue-sampling methods were used to track the toluene as well.

The scientists were surprised by the findings. "I couldn't believe it," Dewey said. "The theory has always been that the effects of solvents would not be very specific -- that if you breathe them in they'd go everywhere equally," he said. "But, in fact, it looks like there's a regional distribution. They go to specific regions associated with reward and pleasure, just like other abused drugs. Then over time, they redistribute."

The initial specificity for the brain's reward centers may help to explain the addictive potential of inhalants, while the redistribution to the entire brain seems to mirror clinical changes observed in huffers. Unlike other drug abusers, who have damage in the reward centers, Dewey explained, "huffers have a much more global disease," with changes in areas of the brain that may interrupt normal learning and memory more quickly than other drugs.

In addition to offering insight into the nature and effects of inhalant abuse, Gerasimov said this study is also a technical advance in radiochemistry. "It's the first time chemists have labeled and purified a solvent for imaging," she said. This may open up a whole new field of study into the effects of a wide array of solvents found in common, everyday products from cleaning fluids to hairsprays. "There isn't a person among us who isn't exposed to solvents," Dewey said.


'"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
15-Apr-2002


Page: 1 2 3

Related medicine news :

1. Brain-imaging study sheds more light on underlying cause of attention-deficit hyperactivity syndrome
2. Brain-imaging cap under study for space and Earth use
3. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
4. UMaine study looks at infants and chronic nighttime crying
5. Chronic pain treatments more effective when taken together, new study shows
6. UNC study: Most N.C. family practitioners engage in unrecognized community service
7. New study in Nature demonstrates protection against cell death during heart attack
8. UCSF study offers insight into human circadian rhythms
9. International breast cancer prevention study launches in the United States and Canada
10. UW study shows blacks and Latinos are more satisfied with physicians of the same race
11. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... York, NY (PRWEB) , ... December 02, 2016 ... ... featuring an inspirational interview of two ostomy patients, standing as living proof that ... people suffer from digestive diseases and issues that spike around the holidays. This ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... ... edition of "Cardiovascular Health" in USA Today, which covers the innovative treatments, therapeutic ... health while maintaining fulfilling lives. “We are prolonging life 6 years in the ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... diagnostic imaging systems and the first company to offer robotic imaging to ... at their tradeshow booth # 941 for the American Association of Equine Practitioners ...
(Date:12/2/2016)... ... 2016 , ... Yisrayl Hawkins, at The House of Yahweh in Abilene, Texas, ... Bible Prophecy. Yisrayl says this generation, known as the Last Generation, started in 1934 ... details line up exactly with Bible Prophecy – a protected way for those who ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... needy individuals and families from eight different sites throughout Miami-Dade and Broward counties. ... 1,000 volunteers worked very hard on Thanksgiving morning by putting together individual meals ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... DUBLIN , Dec 1, 2016 ... report "Drug Delivery in Cancer - Technologies, Markets and Companies" ... , ... a challenge in management of cancer The market value ... separate. Cancer market estimates from 2015-2025 are given according to organs ...
(Date:12/2/2016)... , Dec. 1, 2016 Around the ... country, region and each habitable land present over earth. ... every individual once in a life time this is ... care available until now. Given the steady increase in ... together with the spiraling healthcare costs of treatment, there ...
(Date:12/2/2016)... Allergan plc (NYSE: AGN ), a ... previously announced Accelerated Share Repurchase (ASR) Program. Logo - ... ... previously announced, the Company entered into a variable tenor ASR ... repurchase $10 billion of its ordinary shares. Approximately 40.5 million ...
Breaking Medicine Technology:
Cached News: