HOME >> MEDICINE >> NEWS
Brain transportation system defect linked to Huntington's by UCSD team

Researchers at the University of California, San Diego (UCSD) School of Medicine have linked a defective protein in Huntington's disease to gridlock in the transportation system that moves signals and vital protein cargoes within the brain, eventually leading to neuron cell death.

Published in the September 25, 2003 issue of the journal Neuron, their studies in Drosophila, the fruit fly, showed that a protein called huntingtin is critical for normal neuronal transportation. When the protein is defective, however, it appears to physically blocks traffic in the narrow axons that are the long pipes of the nerve cells.

Although defective huntingtin genes have previously been linked to Huntington's disease, this is the first study to illustrate that the defective protein may cause neuronal damage by aggregating (sticking together) and blocking axonal traffic.

"These findings support our hypothesis that blockage of neuronal transportation is related to several neurodegenerative diseases," said the study's senior author, Lawrence S.B. Goldstein, Ph.D., UCSD professor of cellular and molecular medicine and a Howard Hughes Medical Institute investigator. "In a previous studies (Nature, Dec. 6, 2001 and Neuron, Nov. 8, 2001), we provided evidence that a protein linked to plaque accumulation in Alzheimer's disease is involved in brain cellular trafficking."

In the current study, the Goldstein team removed or reduced the normal huntingtin gene in fruit fly larva. As a result, they found that vesicle traffic up and down the axon was disrupted, indicating that huntingtin's normal function was related to the transport machinery.

Next, the researchers looked at the defective, or pathogenic version of the huntingtin protein, and of other proteins that cause polyglutamine diseases, which are neurodegenerative disorders similar to Huntington's disease. They found that the disease-causing versions of all these genes inhibited the transport
'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
24-Sep-2003


Page: 1 2

Related medicine news :

1. Brain activity prior to treatment flags vulnerability to antidepressant side effects
2. Brain imaging study may hold clues to onset of schizophrenia in people at high risk
3. Brain imaging reveals secrets of love, fear and betrayal
4. Brain imaging studies investigate pain reduction by hypnosis
5. Brain tumor with dismal prognosis in infants can be cured in older children
6. Brain-scanning technologies need standards, according to Stanford researcher
7. Brain activity of men and women during hostile or impulsive acts differs less on nicotine
8. Brain synapse formation linked to proteins, Stanford study finds
9. Brain tumor treatment can vary greatly, according to new JAMA study
10. Brain region identified that controls collecting behavior
11. Brain imaging reveals new language circuits

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... ... ... Pink , a national non-profit organization focusing on the prevention and early detection of breast ... proud to announce Katie Thiede as their new Chief Executive Officer. In January, founder Lindsay ... the Board and launched a national search to find a visionary new leader to grow ...
(Date:4/24/2017)... ... April 24, 2017 , ... ALP ... food supplements, announced its popular products are now available for purchase on StackedNutrition.com, ... prioritizes the use of premium natural ingredients in making all of its products. ...
(Date:4/24/2017)... NEW PORT RICHEY, Fla. (PRWEB) , ... April ... ... Disease Control and Prevention (CDC), rising prescription opioid overdose deaths now claim the ... (DEA) has slashed its civil case filings against drug manufacturers, distributors, pharmacies and ...
(Date:4/24/2017)... ... 2017 , ... As a former supermodel known for her timeless beauty, Joan ... single women is that she put all the words in her new book, "Manifest ... personal experiences and sparkling sense of humor have inspired her to write a book ...
(Date:4/24/2017)... ... ... “Reflections of God’s Work”: an enlightening collection of life lessons leading each ... published author, Jerri Broglin, a survivor of great loss who gained insight on how ... for those searching for answers, as we are finding the answers that are so ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017 /PRNewswire/ - CRH Medical Corporation (TSX: CRH) (NYSE ... Bloom Burton & Co. Healthcare Investor Conference 2017 at the Sheraton ... Edward Wright , Chief Executive Officer of the Company is scheduled ... CFO, Richard Bear and the Chairman of the Board, ... ...
(Date:4/19/2017)... Global Surgical Drainage Device Market: Overview ... remove excess liquid and air. The fluid to be ... lymph. Surgical drains are used in a wide variety ... cardiovascular surgery, neurosurgery, plastic surgery etc. Common use of ... of fluid e.g. blood or pus. Surgical drains are ...
(Date:4/19/2017)... DIEGO , April 19, 2017  Sorrento ... an antibody-centric, clinical-stage biopharmaceutical company developing new treatments ... announced the closing of its previously announced underwritten ... stock at a public offering price of $2.00 ... and estimated offering expenses payable by Sorrento.  The ...
Breaking Medicine Technology:
Cached News: