HOME >> MEDICINE >> NEWS
Brain transportation system defect linked to Huntington's by UCSD team

Researchers at the University of California, San Diego (UCSD) School of Medicine have linked a defective protein in Huntington's disease to gridlock in the transportation system that moves signals and vital protein cargoes within the brain, eventually leading to neuron cell death.

Published in the September 25, 2003 issue of the journal Neuron, their studies in Drosophila, the fruit fly, showed that a protein called huntingtin is critical for normal neuronal transportation. When the protein is defective, however, it appears to physically blocks traffic in the narrow axons that are the long pipes of the nerve cells.

Although defective huntingtin genes have previously been linked to Huntington's disease, this is the first study to illustrate that the defective protein may cause neuronal damage by aggregating (sticking together) and blocking axonal traffic.

"These findings support our hypothesis that blockage of neuronal transportation is related to several neurodegenerative diseases," said the study's senior author, Lawrence S.B. Goldstein, Ph.D., UCSD professor of cellular and molecular medicine and a Howard Hughes Medical Institute investigator. "In a previous studies (Nature, Dec. 6, 2001 and Neuron, Nov. 8, 2001), we provided evidence that a protein linked to plaque accumulation in Alzheimer's disease is involved in brain cellular trafficking."

In the current study, the Goldstein team removed or reduced the normal huntingtin gene in fruit fly larva. As a result, they found that vesicle traffic up and down the axon was disrupted, indicating that huntingtin's normal function was related to the transport machinery.

Next, the researchers looked at the defective, or pathogenic version of the huntingtin protein, and of other proteins that cause polyglutamine diseases, which are neurodegenerative disorders similar to Huntington's disease. They found that the disease-causing versions of all these genes inhibited the transport
'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
24-Sep-2003


Page: 1 2

Related medicine news :

1. Brain activity prior to treatment flags vulnerability to antidepressant side effects
2. Brain imaging study may hold clues to onset of schizophrenia in people at high risk
3. Brain imaging reveals secrets of love, fear and betrayal
4. Brain imaging studies investigate pain reduction by hypnosis
5. Brain tumor with dismal prognosis in infants can be cured in older children
6. Brain-scanning technologies need standards, according to Stanford researcher
7. Brain activity of men and women during hostile or impulsive acts differs less on nicotine
8. Brain synapse formation linked to proteins, Stanford study finds
9. Brain tumor treatment can vary greatly, according to new JAMA study
10. Brain region identified that controls collecting behavior
11. Brain imaging reveals new language circuits

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brain transportation system defect linked Huntington UCSD team

(Date:12/20/2014)... Columbus, OH (PRWEB) December 20, 2014 ... contend they suffered uncontrollable bleeding and other ... District Court, Eastern District of Louisiana for coordinated pretrial ... Panel on Multidistrict Litigation (JPML) issued an order Friday ... tag-along actions pending in 22 federal courts to the ...
(Date:12/19/2014)... Today, Balfleet.com , a leading dress ... formal dress promotion. All the old and new customers ... , Balfleet.com is well-known for its high quality trendy ... cocktail dresses and more. Its formal dresses are quality ... they can create an elegant look when paired with ...
(Date:12/19/2014)... Energy Textiles is excited to ... Celliant, the world’s leading responsive textile, can now ... There are a number of benefits to wearing ... and balanced body temperature; which can lead to ... enhanced athletic performance; and overall wellness. In addition, ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 Eufaula, Oklahoma, ... to Lake Eufaula, the state’s largest lake with more ... town is home to a little more than 3,000 ... P.M. on Saturday, the 6th of December. , Featuring ... way through downtown Eufaula on Main Street. Narconon ...
(Date:12/19/2014)... The print component of Vision and Hearing ... the Toronto Star, with a circulation of approximately 230,433 ... component is distributed nationally through a vast social media ... and partner outlets. To explore the digital version of ... features an exclusive interview with Mark DeMontis , ...
Breaking Medicine News(10 mins):Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 2Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 3Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 4Health News:Balfleet.com Announces Its Formal Dress Promotion For 2015 2Health News:Energy Textiles Launches Celliant Revitalizing Bedsheets 2Health News:Narconon Arrowhead Debuts Float at Checotah and Eufaula Christmas Parades 2Health News:Narconon Arrowhead Debuts Float at Checotah and Eufaula Christmas Parades 3Health News:Mark DeMontis, Founder of Courage Canada, shares his passion for bringing hockey to those affected by blindness in Mediaplanet’s “Vision and Hearing” campaign 2
(Date:12/19/2014)... 2014 Research and Markets ( ... "Micro Market Monitor: North American Dermatology Diagnostic ... http://photos.prnewswire.com/prnh/20130307/600769 ... which has resulted in fueling the overall demand ... purpose of these dermatology devices is to assist ...
(Date:12/19/2014)... Baptist Health Lexington is the first facility in ... Atrial Fibrillation with Electrophysiology Services (EPS) Accreditation status from the ... is the most common cardiac arrhythmia and has become recognized ... to stroke and possible death. More than 5 million patients ... fibrillation and the numbers are rapidly increasing as the population ...
(Date:12/17/2014)... AMSTERDAM and SAN DIEGO , ... PHG ; AEX: PHIA) and Volcano Corporation (NASDAQ: ... and measurement solutions for cardiovascular applications, today announced that they ... agreement, Philips will commence a tender offer to acquire all ... 18.00 per share, or a total equity purchase price of ...
Breaking Medicine Technology:Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3Philips to acquire Volcano to expand global leadership position in image-guided therapy market 2Philips to acquire Volcano to expand global leadership position in image-guided therapy market 3Philips to acquire Volcano to expand global leadership position in image-guided therapy market 4Philips to acquire Volcano to expand global leadership position in image-guided therapy market 5Philips to acquire Volcano to expand global leadership position in image-guided therapy market 6Philips to acquire Volcano to expand global leadership position in image-guided therapy market 7Philips to acquire Volcano to expand global leadership position in image-guided therapy market 8
Cached News: