HOME >> MEDICINE >> NEWS
Brain tumor with dismal prognosis in infants can be cured in older children

Some children with a rare brain tumor that is considered almost universally fatal can be saved if they receive radiation therapy followed by tandem (given one after the other) cycles of high-dose chemotherapy. This finding, from researchers at St. Jude Children's Research Hospital, is published in the March 1 issue of the Journal of Clinical Oncology (JCO).

The tumor, called atypical teratoid/rhabdoid tumor (ATRT), is a rare aggressive cancer that arises either in the cerebellum or cerebral cortex and often spreads through the central nervous system. The cerebellum is the lower, back part of the brain that controls balance.

The St. Jude team showed that, while children with ATRT under three years of age have a dismal prognosis, children older than 3 can be cured by upfront treatment with radiation followed by chemotherapy using so-called alkylating agents (cyclophosphamide, cisplatin, vincristine and etoposide), according to Amar Gajjar, M.D., director of St. Jude Neuro-oncology. In this case, physicians first surgically removed as much of the tumor as possible before treating children with radiation followed by chemotherapy.

The success in raising the survival rate among these children reflects the long-standing leadership of St. Jude in addressing the needs of children who suffer from rare cancers, as well as more common malignancies, according to Gajjar.

"Effective therapy for patients with ATRT has remained elusive until now, at least for children older than 3 years," said Gajjar, senior author of the JCO report. "The fact that we found that upfront radiation is so effective, especially in older children, suggests that this should become a standard approach to ATRT therapy."

Gajjar's team studied the medical records of 31 patients, 22 of whom were younger than 3 years old. All patients had surgery, and 30 received subsequent chemotherapy. Most patients who were 3 years old or older received postoperative radiation to their brains and
'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
2-Mar-2005


Page: 1 2

Related medicine news :

1. Brain activity prior to treatment flags vulnerability to antidepressant side effects
2. Brain imaging study may hold clues to onset of schizophrenia in people at high risk
3. Brain imaging reveals secrets of love, fear and betrayal
4. Brain imaging studies investigate pain reduction by hypnosis
5. Brain-scanning technologies need standards, according to Stanford researcher
6. Brain activity of men and women during hostile or impulsive acts differs less on nicotine
7. Brain synapse formation linked to proteins, Stanford study finds
8. Brain tumor treatment can vary greatly, according to new JAMA study
9. Brain region identified that controls collecting behavior
10. Brain imaging reveals new language circuits
11. Brain can be trained to process sound in alternate way, study shows

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/21/2020)... ... February 21, 2020 , ... The ... World Cancer Leaders’ Summit in Boston, MA, in October 2021. The prestigious, invitation-only ... makers including prime ministers, ministers of health, city and industry leaders, senior executives ...
(Date:2/20/2020)... ... February 20, 2020 , ... TMQuotes , a ... next generation API integration functionality which enables agents to take more involved ownership ... TMQuotes was the first white label software-as-a-service (SaaS) to give insurance agents and ...
(Date:2/19/2020)... (PRWEB) , ... February 19, 2020 , ... ... MedTech Start Up Founders Encouraged to Apply to Participate in 2020 Cohort , ... MedTech IGNITE program is now accepting applications from startup founders and ...
(Date:2/19/2020)... ... 19, 2020 , ... SafiraMD Medical Aesthetics & Wellness Center ... world’s most popular non-invasive fat reduction treatment. Their CoolEvent will be held on ... in Alpharetta, Georgia. The CoolEvent will feature live demonstrations, exclusive discounts, giveaways and ...
(Date:2/15/2020)... ... February 14, 2020 , ... It all started back in ... drawing these heart-shaped characters and knew she was on to something special. The ... navigate through any life challenge including a health condition or illness, a disability or ...
Breaking Medicine News(10 mins):
(Date:2/19/2020)... (PRWEB) , ... February 19, 2020 , ... A new ... presence of oxygen-deprived clusters throughout the damaged site of a compressed spinal cord. It ... of a viral vector to target the oxygen-deprived sites enhances the injured spinal cord’s ...
(Date:2/19/2020)... ... February 19, 2020 , ... The Team Type 1 Foundation, ... medicine for everyone affected by diabetes, announced a partnership with VeloCity, a fundraising ride ... third annual VeloCity event takes place on May 2nd and begins on the Mercedes-Benz ...
(Date:2/16/2020)... ... February 16, 2020 , ... In Partnership with the ... dental services at its Kennewick, WA office. , A limited number of appointments are ... schedule beforehand. For more information or to schedule an appointment, please call (509)-820-4302. , ...
Breaking Medicine Technology:
Cached News: