HOME >> MEDICINE >> NEWS
Brain tumor with dismal prognosis in infants can be cured in older children

Some children with a rare brain tumor that is considered almost universally fatal can be saved if they receive radiation therapy followed by tandem (given one after the other) cycles of high-dose chemotherapy. This finding, from researchers at St. Jude Children's Research Hospital, is published in the March 1 issue of the Journal of Clinical Oncology (JCO).

The tumor, called atypical teratoid/rhabdoid tumor (ATRT), is a rare aggressive cancer that arises either in the cerebellum or cerebral cortex and often spreads through the central nervous system. The cerebellum is the lower, back part of the brain that controls balance.

The St. Jude team showed that, while children with ATRT under three years of age have a dismal prognosis, children older than 3 can be cured by upfront treatment with radiation followed by chemotherapy using so-called alkylating agents (cyclophosphamide, cisplatin, vincristine and etoposide), according to Amar Gajjar, M.D., director of St. Jude Neuro-oncology. In this case, physicians first surgically removed as much of the tumor as possible before treating children with radiation followed by chemotherapy.

The success in raising the survival rate among these children reflects the long-standing leadership of St. Jude in addressing the needs of children who suffer from rare cancers, as well as more common malignancies, according to Gajjar.

"Effective therapy for patients with ATRT has remained elusive until now, at least for children older than 3 years," said Gajjar, senior author of the JCO report. "The fact that we found that upfront radiation is so effective, especially in older children, suggests that this should become a standard approach to ATRT therapy."

Gajjar's team studied the medical records of 31 patients, 22 of whom were younger than 3 years old. All patients had surgery, and 30 received subsequent chemotherapy. Most patients who were 3 years old or older received postoperative radiation to their brains and
'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
2-Mar-2005


Page: 1 2

Related medicine news :

1. Brain activity prior to treatment flags vulnerability to antidepressant side effects
2. Brain imaging study may hold clues to onset of schizophrenia in people at high risk
3. Brain imaging reveals secrets of love, fear and betrayal
4. Brain imaging studies investigate pain reduction by hypnosis
5. Brain-scanning technologies need standards, according to Stanford researcher
6. Brain activity of men and women during hostile or impulsive acts differs less on nicotine
7. Brain synapse formation linked to proteins, Stanford study finds
8. Brain tumor treatment can vary greatly, according to new JAMA study
9. Brain region identified that controls collecting behavior
10. Brain imaging reveals new language circuits
11. Brain can be trained to process sound in alternate way, study shows

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder ... of ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership ... rules. It also provides a forum to network with elder law attorneys nationwide,” said ...
(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
(Date:10/13/2017)... Abilene, Texas (PRWEB) , ... October 13, 2017 , ... ... publication this week that explains one of the most popular and least understood books ... seems like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the ... save lost souls in the Philippines. “The Journey: From the Mountains to the Mission ... of the Bible. She has taught all ages and currently teaches a class of ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco dentists, ... cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated to ... breathing. Oral appliances can offer significant relief to about 75 percent of people ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), will ... and webcast on Friday, November 3, 2017, beginning at ... at approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... financial performance and guidance for 2018, Hill-Rom executives will ... operational performance, and long-range financial outlook through 2020. ...
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., a ... design, and immune-engineering today announced the launch of ... development of personalized therapeutic cancer vaccines. EpiVax has ... exclusive access to enabling technologies to the new ... will lead EpiVax Oncology as Chief Executive Officer. ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., a ... today announced that it has been ranked #1 by its ... Book™ Rankings 2017 User Survey. ZirMed was recognized as ... large hospitals and medical centers over 200 beds and holds ... healthcare technology user survey history. ...
Breaking Medicine Technology:
Cached News: