HOME >> MEDICINE >> NEWS
Brain's efforts to save itself during Alzheimer's may backfire

The creation of a new transgenic mouse that makes a mysterious brain chemical may lead to better understanding of why people with Alzheimers disease lose their memory.

The neurotransmitter galanin appears to play a role in the disease, and scientists are now trying to figure out how and why. Galanin is normally neuro-protective, following brain injury. One possibility is that the brain overproduces galanin during the early stages of Alzheimers in an effort to rescue the afflicted brain but, over time, the brains own attempted cure makes a bad situation worse.

"This could be a sad irony. The body may be detecting the underlying pathology of Alzheimer's and tries to rescue deteriorating brain cells with increased expression of galanin. Very early on in the disease, galanin might even be having beneficial effects," said Dr. Robert Steiner, a professor in the departments of Obstetrics and Gynecology, and Physiology and Biophysics, at the University of Washington School of Medicine. "As the brain attempts to rescue itself with galanin and the disease progresses, the overexpression of galanin may become its own problem. This excess of galanin may contribute to the cognitive decline that Alzheimer's patients and their families so dread. "

The findings of Steiner and colleagues are published in the March 20 issue of Proceedings of the National Academy of Sciences. Co-authors include Dr. Jacqueline N. Crawley, chief of the Section on Behavioral Neuropharmacology, the National Institute of Mental Health; Dr. Elliott J. Mufson, professor in the Department of Neurological Sciences at Rush Presbyterian-St. Lukes Medical Center in Chicago; and Dr. John Hohmann, who was then a doctoral student in the neurobiology and behavior program at the University of Washington.

If galanin is playing a role in the disease, then what we know as Alzheimers could be the result of many parallel events that themselves create complications. Crawley said that galanin will need to b
'"/>

Contact: Walter Neary
wneary@u.washington.edu
206-685-3841
University of Washington
18-Mar-2001


Page: 1 2 3 4

Related medicine news :

1. Brains nicotine receptors also target for anti-depressants
2. Brains immune system triggered in autism
3. Brains daydream network offers detection for Alzheimers diagnosis
4. Novel Imaging Agent Developed By Penn Researchers Provides Insight Into Brains Message Delivery System
5. PITT Researchers Demonstrate Human Brains Natural Mechanism For Guarding Against Errors
6. 3D Ultrasound Gives Better View Of Brains Arteries
7. Computational tool predicts how drugs work in cells, advancing efforts to design better medicines
8. New European cancer figures for 2004 major efforts needed against the big four killers
9. Campus can be effective site for anti-smoking efforts
10. HIV/AIDS conspiracy theories may hamper efforts to halt the disease
11. Exposed: Tobacco industrys efforts to cast doubt

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brain efforts save itself during Alzheimer may backfire

(Date:4/17/2014)... to a study published today in PLOS Pathogens ... where malaria is common can mount an immune response ... to avoid repeated bouts of high fever and illness ... their bloodstream. The findings may help researchers develop future ... the malaria parasite. , Each year, approximately 200 million ...
(Date:4/17/2014)... In a review published in the April issue of ... The Feinstein Institute for Medical Research, says it,s time ... approach to treating sepsis, which kills millions ... Sepsis occurs when molecules released into the bloodstream to ... body. Inflammation is necessary for maintaining good health ...
(Date:4/17/2014)... 2014) Doctors who treat patients with a ... can face an agonizing treatment decision. , The ... and help relieve shortness of breath. But some ... can cause potentially fatal complications following transplantation. , ... Dilling, medical director of Loyola University Medical Center,s ...
(Date:4/17/2014)... Calif., April 17, 2014 By discovering a new ... after a stroke, researchers at UC Irvine and the ... that may limit or prevent stroke-induced brain damage. , ... fourth-leading cause of death and primary reason for disability ... in a stroke and lets blood-borne material into the ...
(Date:4/17/2014)... potential to ward off depression among retirees, particularly among ... in The Journals of Gerontology, Series B: ... article " Internet Use and Depression Among Retired Older ... the authors report that Internet use reduced the probability ... study sample. , Late-life depression affects between 5 ...
Breaking Medicine News(10 mins):Health News:Study sheds light on how the immune system protects children from malaria 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:Study IDs new cause of brain bleeding immediately after stroke 2Health News:Internet use may cut retirees' depression 2
(Date:1/15/2014)... 15, 2014 MultiCell Technologies, Inc. (OTC Bulletin Board: ... patent application concerning composition of matter, biological targets, mechanism ... cell death.  This patent application describes ... RNA molecules (VSRNAs) which interfere with the basic homeostatic ...
(Date:1/15/2014)... YORK , Jan. 15, 2014 ... report is available in its catalogue: ... Forecast – Worldwide Analysis ... Market Analysis Insulin ...
(Date:1/15/2014)... 15, 2014 Reportlinker.com announces that ... available in its catalogue: ... for Advanced Drug Delivery Systems -- ... http://www.reportlinker.com/p01941928/Global-Markets-and-Technologies-for-Advanced-Drug-Delivery-Systems----Focus-on-Routes-of-Administration.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Delivery_Technology ...
Breaking Medicine Technology:MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16
Cached News: