Brain's nicotine receptors also target for anti-depressants

New Haven, Conn.--The same receptors in the brain that are activated when a person smokes cigarettes also play a critical role in the effectiveness of antidepressants, according to a study by Yale researchers in the November issue of Biological Psychiatry.

What this means, particularly for patients who are suicidal, is that finding a way to activate these receptors will make anti-depressants work more quickly. Most anti-depressants now take up to three weeks to bring emotional relief.

"Just the ability to block the reuptake of serotonin isn't enough, otherwise it wouldn't take two to three weeks to be effective, " said Marina Picciotto, associate professor of psychiatry, pharmacology and neurobiology at Yale School of Medicine and senior author of the study. "This finding has implications for those patients who are depressed to the point of being suicidal, and for the 30 percent of people who are not responsive to anti-depressants that are now available."

The primary pharmacologic treatment for depression over the past several decades has been drugs that inhibit synaptic reuptake of monoamine neurotransmitters. Recent evidence indicates other neurotransmitter systems might play a role in the mechanism of action of antidepressants, Picciotto said.

In this study in mice, she and her colleagues tested the action of antidepressants with and without mecamylamine, a noncompetitive antagonist (blocker) in nicotinic acetylcholine receptors (nAChRs). In a separate study using knockout mice that lack these receptors, they found that the function of the nicotine receptor in the brain was an essential component of the therapeutic action of antidepressants.

Picciotto said the next step will be to study the role of nAChRs in regulating the behavioral and cellular responses to antidepressants. They will see if there is a direct effect mediated by nAChRs or an indirect effect of modulating neurotransmission in other cell types. "Use of more s

Contact: Jacqueline Weaver
Yale University

Page: 1 2

Related medicine news :

1. Brains immune system triggered in autism
2. Brains daydream network offers detection for Alzheimers diagnosis
3. Brains efforts to save itself during Alzheimers may backfire
4. Novel Imaging Agent Developed By Penn Researchers Provides Insight Into Brains Message Delivery System
5. PITT Researchers Demonstrate Human Brains Natural Mechanism For Guarding Against Errors
6. 3D Ultrasound Gives Better View Of Brains Arteries
7. Studies underscore genetic involvement in nicotine addiction & aggressive hostility
8. Brain activity of men and women during hostile or impulsive acts differs less on nicotine
9. Animal study shows link between nicotine and atrial flutter
10. Free nicotine patches increase short-term smoking quit rates
11. Antidepressant may help people stop smoking when used with nicotine patch

Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a ... has been awarded a contract by the Center for Medicare and Medicaid Services ... accelerate the enterprise use of Agile methodologies in a consistent and high value ...
(Date:10/13/2017)... ... , ... “America On The Brink”: the Christian history of the United States ... creation of published author, William Nowers. Captain Nowers and his wife, Millie, have ... thirty years in the Navy. Following his career as a naval aviator and ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 ... characterized by frequent cessation in breathing. Oral appliances can offer significant relief to ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has ... today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula ... the highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, ...
(Date:10/12/2017)... ... 12, 2017 , ... The American College of Medical Informatics (ACMI) will present ... the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... Collen, a pioneer in the field of medical informatics, this prestigious award is presented ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... IRVING, Texas , Oct. 6, 2017   ... industry with more than $100 billion in purchasing power, ... industry news and information. The Newsroom is ... chain and industry trends, infographics, expert bios, news releases, ... Besides having access to a wealth of resources at ...
(Date:10/4/2017)... , Oct. 4, 2017 ... single-use, self-contained, illuminating medical devices, today announced regulatory ... Health Surveillance Agency (or Agência Nacional de Vigilância ... first single-use, cordless surgical retractor with integrated LED ... optimal access, illumination and exposure of a tissue ...
(Date:10/2/2017)... -- Halo Labs announces the European launch of their new low ... MIBio 2017 in Cambridge, U.K on October ... biopharmaceutical samples with unprecedented speed and sensitivity while using far less ... Imaging. ... analysis system ...
Breaking Medicine Technology:
Cached News: