HOME >> MEDICINE >> NEWS
Breaking down the walls of immunological ignorance

T cells that respond to an antigen challenge in vitro but fail to do so in a living animal are said to be in a state of immunological ignorance. Chen and his colleagues have argued for some time that this poorly understood state can help explain the workings and, crucially, the failings of immunological surveillance for tumors. Ignorance of tumor antigens has been ascribed to the lack of costimulatory signals, and it appears that one strategy of immune evasion by tumors is the down regulation of otherwise common costimulatory activators. Still, some experimentally induced tumors, expressing known tumor antigens that are targeted by defined CTL clones, can be eliminated when T cells are provided an additional, costimulatory signal. In their current report, Wilcox et al. develop a useful reagent for this purpose, and they show that such a co-stimulatory treatment is not always sufficient to induce tumor regression. The authors injected a monoclonal antibody to the costimulatory mediator CD137, a T cell?borne relative of the TNF receptor. This novel agonistic antibody stimulates the expansion and activation of the necessary CTL clone, allowing animals with one type of carcinoma undergo a dramatic tumor regression following treatment. Interestingly, another tumor type, a thymoma that displays the same tumor antigen, is refractory to this treatment, indicating that the CTLs remain ignorant of the antigen when it occurs in the latter context. Wilcox et al. find that this ignorant state can be overcome when the animals are provided not just the agonistic antibody, but also an antigenic peptide recognized by the tumor-specific CTL. Hence, they argue that either inadequate levels of the presented antigen or insufficient costimulatory signaling through CD137 can lead to immunological ignorance and allow tumor growth to proceed unchecked. Providing one or both of these signals might therefore heighten the efficiency of tumor surveillance in animals with spontaneous tumors as w
'"/>

Contact: John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation
27-Feb-2002


Page: 1 2

Related medicine news :

1. Breaking the worst possible news in the best possible manner
2. Breaking the barriers of distance and time
3. Baby Milk Manufacturers Are Breaking The Rules
4. Penn Researchers Initiate Ground-Breaking New Trials To Treat
5. HIV-infected have thicker carotid artery wallspredictor of heart attack & stroke
6. Early heart disease in parents linked to thicker artery walls in offspring
7. Obese women have thicker carotid artery walls, higher stroke risk
8. Self-assembled nano-capsules resemble bacterial cell walls

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... September 03, 2020 , ... International Dark-Sky ... WALI wireless parking lot controller. This advanced LED wireless dimming controller, along with ... and protecting the night sky against light pollution. Leo Smith, the Northeast Regional ...
(Date:9/1/2020)... ... September 01, 2020 , ... Feeding Matters , ... children with Pediatric Feeding Disorder (PFD), is pleased to announce that the U.S. Centers ... diagnostic code (R code) in the next edition of the U.S. International Classification ...
(Date:8/31/2020)... NEW YORK (PRWEB) , ... August 31, 2020 ... ... the nation’s largest non-profit organization devoted exclusively to funding innovative lymphoma research and ... and patient services – today announced the 10th Anniversary of Blood Cancer Awareness ...
(Date:8/31/2020)... ... August 31, 2020 , ... Genesis ... chiropractors, announced today the launch of its integrated, HIPAA compliant, telehealth solution, available ... virtual practice in under 90 seconds. , According to the U.S. Department ...
(Date:8/31/2020)... , ... August 31, 2020 , ... A Cure for Covid-19 “PTS” with Mediation & ... the planet are in a state of panic, experiencing deep anxiety, immense stress, and right ... a solution is timely when most people on the planet are experiencing a great degree ...
Breaking Medicine News(10 mins):
(Date:9/3/2020)... ... ... Using Analysis of Variance — A Practical Approach:, Perform Statistical Analysis Without ... https://www.fdanews.com/anova , How much would it help one’s Quality Management System if ... 90 minutes, one can master a powerful statistical technique in that time — Analysis ...
(Date:9/2/2020)... ... September 02, 2020 , ... ... Penetration Technology, LLC, (APT) a Texas- and Indiana-based company ( http://www.aptt3x.com ) ... Counter (OTC) products, was today provided results of an independent laboratory evaluation ...
(Date:9/1/2020)... ... September 01, 2020 , ... Mara C. Weinstein Velez, M.D., ... the University of Rochester Medical Center, in Upstate New York. She completed a ... clinical faculty from the Harvard and Yale Departments of Dermatology and is one ...
Breaking Medicine Technology:
Cached News: