HOME >> MEDICINE >> NEWS
Breast cancer patients with BRCA1 or 2 mutations twice as likely to have double mastectomy

Washington, DC -- Newly diagnosed breast cancer patients who test positive for a BRCA1 or BRCA2 gene mutation are twice as likely to opt for bilateral or double mastectomy, taking the most aggressive surgical stance to treat their current cancer and reduce their risk for future breast cancer.

The study, led by researchers at Georgetown University Medical Center's Lombardi Comprehensive Cancer Center (LCCC) and published online today in the Journal of Clinical Oncology, is the largest to date that evaluates if genetic testing offered at the time of breast cancer diagnosis affects patients' breast cancer treatment decisions.

In contrast to the 48 percent of women who had double mastectomies after testing positive for a BRCA1 or BRCA 2 mutation, 24 percent of patients with no mutation and four percent of test decliners opted for the more extensive surgery.

"Rapid genetic counseling and testing could serve as a valuable decision-making tool for newly diagnosed breast cancer patients at high risk for carrying a mutation," said Marc Schwartz, Ph.D., associate professor of oncology at Georgetown's LCCC. "Prophylactic mastectomy remains controversial, but this study suggests that for some patients who learn that they are at high risk for developing a second breast cancer, bilateral mastectomy becomes a viable alternative to more traditional breast-conserving therapy or unilateral mastectomy."

A woman who tests positive for the BRCA1/2 mutation has a 40-65 percent risk of contralateral breast cancer meaning breast cancer in the non-cancerous breast. While breast conserving therapy (a combination of lumpectomy plus radiation) and unilateral mastectomy are effective treatments for the newly diagnosed breast cancer, these treatments do not protect against the development of a new breast cancer in the opposite breast.

Although testing was provided free of charge in this study, most insurance companies cover most of the cost for B
'"/>

Contact: Elizabeth McDonald
eem6@georgetown.edu
202-687-7707
Georgetown University Medical Center
5-Apr-2004


Page: 1 2

Related medicine news :

1. Hausman to give keynote address at Breastfeeding, Motherhood and Feminism symposium
2. Breast implant Website launched by leading plastic surgery societies
3. Breast cancer treatment reduces risk of heart disease
4. Breast reconstruction with implants after mastectomy doesnt hurt survival chances
5. Breast cancer may be uniquely sensitive to inhibitors of PI3K pathway
6. Breast MRI moderately useful for detecting breast cancer, but does not eliminate need for biopsy
7. Breast conserving therapy safe for hereditary breast cancer
8. Breast cancer risk, prognosis and weight gain reduced with physical activity
9. Breast cancer in Asian Americans is rising faster than in any other ethnic group
10. Long Island Breast Cancer Study data: Aspirin helps protect some women against breast cancer
11. Breast cancer in men increasing

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give back to ... 10 percent of each hotel room booked with a special new rate code to ... Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any room type, ...
(Date:8/29/2020)... ... , ... When professor and author Randy Pausch was diagnosed with pancreatic cancer, ... than become melancholic, however, he put together a final lecture in Carnegie Hall in ... a negative situation and turned it into something that inspired millions of people worldwide. ...
(Date:8/28/2020)... Calif. (PRWEB) , ... August 28, 2020 , ... ... cover a one-year subscription to a customized Lighthouse Health & Wellness mobile app ... support of this project. Motorola Solutions Foundation awards grants each year to organizations, ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... ... role in advising Adventist Health on its investment in Synchronous Health, a tech-enabled ... company that combines the strength of human empathy with artificial intelligence (AI) to ...
(Date:8/27/2020)... ... August 27, 2020 , ... The team at Sikara ... and wellness retreat. The practice is centered on results and providing the ultimate ... , Designed to be a sanctuary for total body renewal and aesthetic revitalization, ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... N.C. (PRWEB) , ... September 01, 2020 , ... While ... an alarming rate as businesses, schools and community organizations remain closed. Because about 80% ... urgently needs the help of both blood donors and blood drive hosts to ensure ...
(Date:9/1/2020)... ... September 01, 2020 , ... September is National Ovarian Cancer Awareness ... deaths than any other cancer of the female reproductive system. The American Cancer ... and about 14,000 women will die from this disease. Throughout the month of ...
(Date:8/31/2020)... ... ... you live in New York City you will always pay more for these two things: ... supply and demand, but are plastic surgeons in New York worth the premium prices that ... make the four-hour trip to have expert aesthetic treatments by some of the best doctors ...
Breaking Medicine Technology:
Cached News: