HOME >> MEDICINE >> NEWS
Broad-based vaccination of wild mice could help reduce lyme disease risk in humans

nown as erythema migrans, as well as fatigue, chills and fever, headache, muscle aches and joint pain. Early treatment prevents the development of more debilitating symptoms. Lyme disease is most commonly found in the northeastern, mid-Atlantic and upper north-central regions of the United States, as well as parts of northwestern California.

In their study, the research team took aim at the larval form of the blacklegged tick, the crucial stage during which a tick becomes infected with B. burgdorferi. Normally, uninfected tick larvae pick up the bacterium the first summer of their two-year life cycle while taking their first blood meal from infected small animals, such as the white-footed mouse. The white-footed mouse is considered a key animal reservoir for Lyme disease. One year later, after the larva develops into a nymph, it feeds on a second animal host, possibly a human, infecting that host. Roughly 90 percent of human infections are contracted from nymphal ticks.

The researchers' goal was to reduce the level of B. burgdorferi infection in nymphal ticks. By vaccinating a large sample of white-footed mice, the researchers hypothesized, fewer tick larvae would become infected the first summer and, in turn, fewer nymphs would be capable of transmitting the disease to humans the following summer.

Throughout the summers of 1998 and 2001, researchers trapped and vaccinated a total of more than 900 mice in 12 different forested sites in Connecticut--six unique sites each summer. In half of the sites, mice received injections of active vaccine; in the other six sites, mice received a placebo.

The vaccine contained a recombinant protein--called OspA--normally found on the outer surface of B. burgdorferi in ticks but not in mice. The vaccine is based on one previously used in humans and currently used in dogs. When an infected nymph feeds on an immunized mouse, the animal's antibodies kill the bacterium inside the nymph, preventing the ny
'"/>

Contact: Jennifer Wenger
jwenger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
13-Dec-2004


Page: 1 2 3 4

Related medicine news :

1. Many children are undervaccinated or have delayed vaccinations in their first 2 years of life
2. Influenza vaccination programmes for children in USA and Canada based on little evidence
3. Flu vaccination benefits people of any age with high-risk medical conditions
4. Flu vaccination impact on elderly deaths may be over-estimated
5. Risk factors affect parents attitudes about STD vaccinations
6. Parents comfortable with vaccination for sexually transmitted infections for adolescent children
7. Study documents decline in rare paralytic disorder linked to influenza vaccination
8. Annual vaccination against influenza associated with decreased risk of death in elderly
9. Hib infections on the rise in adults despite child vaccination programme
10. Most physicians agree that widespread routine influenza vaccination for young children is feasible
11. Childhood vaccination coverage affected by temporary suspension of hepatitis B vaccine

Post Your Comments:
(Date:9/4/2015)... ... 04, 2015 , ... Friday night, Chicago lovebirds Jenny McCarthy and Donnie Wahlberg ... Hope event supporting families affected by autism, raising nearly $250,000. , 150 guests, ... at the Oscar Swan Inn to support the cause. , McCarthy tugged the ...
(Date:9/3/2015)... ... 03, 2015 , ... TransPack Toon gives users a set of 90 cartoon ... framing transitions in 30 different styles. Presets range from snow, underwater, forest, futuristic, city ... TransPack Toon features 90 cartoon transitions from 30 unique styles. Editors can choose ...
(Date:9/3/2015)... ... September 03, 2015 , ... E-Volve ... a leading national healthcare solutions organization, to provide electronic medical record (EMR) consulting ... agreement, Amerinet members will receive negotiated pricing on E-Volve Health’s Epic EMR consulting, ...
(Date:9/3/2015)... ... September 03, 2015 , ... DriButts, a non-profit organization dedicated ... Product Development Group to manufacture a long-lasting reusable diaper for warm weather climates ... to bring 600 DriButts Diapers to rural areas of Haiti during a trip ...
(Date:9/3/2015)... ... September 03, 2015 , ... ... to be situated at 4400 Columbine Drive in Bellingham, Washington. Silverado Bellingham, a ... has been carefully designed to serve up to 80 people living with Alzheimer’s, ...
Breaking Medicine News(10 mins):Health News:Jenny McCarthy & Donnie Wahlberg Help Raise Over $200,000 For Generation Rescue’s ‘Night Of Hope’ Chicago Charity Event 2Health News:Pixel Film Studios Releases TransPack Toon, a New FCPX Transition 2Health News:E-Volve Health to Offer EMR Consulting Solutions to Amerinet Members 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 3Health News:Site Dedication Ceremony to Celebrate New Silverado Memory Care Community 2
(Date:9/3/2015)... Sept. 3, 2015 Report ... New Drugs, Industry Changes and Emerging Opportunities What,s ... ovaries? Visiongain,s new study forecasts those pharmaceutical revenues. ... that industry. You also explore trends, results, treatments, ... report gives revenue predictions to 2025 at overall ...
(Date:9/3/2015)... About self-monitoring blood glucose device ... device. It consists of a glucose sensor and ... through radiowaves from the sensor to a receiver, ... self-monitoring blood glucose devices can improve self-management of ... diabetes treatment. Technavio,s analysts forecast the ...
(Date:9/3/2015)... Nevro Corp. (NYSE: NVRO ), a ... solutions for the treatment of chronic pain, today announced ... Stanley Global Healthcare Conference on Thursday, September 17, 2015 ... is scheduled to present at 11:45 a.m. ET.  The ... accessible in the "Investors" section of the company,s website ...
Breaking Medicine Technology:Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 2Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 3Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 4Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 5Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 6Global Self-monitoring Blood Glucose Devices Market 2015-2019 2
Cached News: