Broad-based vaccination of wild mice could help reduce lyme disease risk in humans

nown as erythema migrans, as well as fatigue, chills and fever, headache, muscle aches and joint pain. Early treatment prevents the development of more debilitating symptoms. Lyme disease is most commonly found in the northeastern, mid-Atlantic and upper north-central regions of the United States, as well as parts of northwestern California.

In their study, the research team took aim at the larval form of the blacklegged tick, the crucial stage during which a tick becomes infected with B. burgdorferi. Normally, uninfected tick larvae pick up the bacterium the first summer of their two-year life cycle while taking their first blood meal from infected small animals, such as the white-footed mouse. The white-footed mouse is considered a key animal reservoir for Lyme disease. One year later, after the larva develops into a nymph, it feeds on a second animal host, possibly a human, infecting that host. Roughly 90 percent of human infections are contracted from nymphal ticks.

The researchers' goal was to reduce the level of B. burgdorferi infection in nymphal ticks. By vaccinating a large sample of white-footed mice, the researchers hypothesized, fewer tick larvae would become infected the first summer and, in turn, fewer nymphs would be capable of transmitting the disease to humans the following summer.

Throughout the summers of 1998 and 2001, researchers trapped and vaccinated a total of more than 900 mice in 12 different forested sites in Connecticut--six unique sites each summer. In half of the sites, mice received injections of active vaccine; in the other six sites, mice received a placebo.

The vaccine contained a recombinant protein--called OspA--normally found on the outer surface of B. burgdorferi in ticks but not in mice. The vaccine is based on one previously used in humans and currently used in dogs. When an infected nymph feeds on an immunized mouse, the animal's antibodies kill the bacterium inside the nymph, preventing the ny

Contact: Jennifer Wenger
NIH/National Institute of Allergy and Infectious Diseases

Page: 1 2 3 4

Related medicine news :

1. Many children are undervaccinated or have delayed vaccinations in their first 2 years of life
2. Influenza vaccination programmes for children in USA and Canada based on little evidence
3. Flu vaccination benefits people of any age with high-risk medical conditions
4. Flu vaccination impact on elderly deaths may be over-estimated
5. Risk factors affect parents attitudes about STD vaccinations
6. Parents comfortable with vaccination for sexually transmitted infections for adolescent children
7. Study documents decline in rare paralytic disorder linked to influenza vaccination
8. Annual vaccination against influenza associated with decreased risk of death in elderly
9. Hib infections on the rise in adults despite child vaccination programme
10. Most physicians agree that widespread routine influenza vaccination for young children is feasible
11. Childhood vaccination coverage affected by temporary suspension of hepatitis B vaccine

Post Your Comments:
(Date:5/6/2015)... Vancouver Chiropractic Clinic, Backs in ... blog containing the Canadian Physical Activity and Sedentary ... for Exercise Physiology (CSEP). Since the CSEP is ... fitness research and personal training in Canada, its ... beneficial and a rich resource for many people. ...
(Date:5/6/2015)... California (PRWEB) May 06, 2015 ... hand sanitizers are increasing, driven by the rising consumer ... the spread of contagious diseases. Hand washing is becoming ... of consumer apprehension over contracting infections. Periodic outbreak of ... the recent Ebola virus disease (EVD) epidemic ...
(Date:5/6/2015)... 06, 2015 Healthcare jobs ... after launching in mid-February. The company connects hospitals, home-health, ... previous experience in the industry. Likewise, job seekers are ... to Kyle Johnson, CTO, unique traffic to the site ... month: "Each new job posting brings targeted, interested candidates ...
(Date:5/6/2015)... 2015 TU-Automotive has opened press registration ... vehicles make it to the headlines of major publications ... GM, Volvo and Hyundai ready to share their visions ... the only way for press to go behind the ... marketing director, TU-Automotive said “This year we’re releasing a ...
(Date:5/6/2015)... 06, 2015 The 2015 STEMtech conference ... Corporate Partner booth selection . Don’t miss this ... community college and university decision-makers from around the country. ... 2015, at the Arizona Grand in Phoenix. This beautiful ... on the doorstep of the South Mountain Preserve. The ...
Breaking Medicine News(10 mins):Health News:Vancouver Chiropractor Shares Canadian Physical Activity and Sedentary Behavior Guidelines by CSEP in New Blog 2Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 2Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 3Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 4Health News:Job Seekers Turn to JobMedic to Find Healthcare Positions - JobMedic.com Reaches 1,000 User Milestone 2Health News:Press Registration for TU-Automotive Detroit Now Open 2Health News:STEMtech Conference Exhibitors Gain Access to Community College and University Representatives From Across the U.S. 2
(Date:5/6/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/rd24gk/chromatography ) ... (Instruments and Reagents) Global Market - Forecast to ... Chromatography is an analytical technique, a method of ... mixture by differential movement through a two phase ... chromatography as an esoteric art, which mainly involves ...
(Date:5/6/2015)... , May 06, 2015 Research and Markets ... addition of the "Global Insulin Patch Market ... Highly advanced technology like ultrasound and iontophoresis ... insulin patches. Depending upon the type of technique, ... of reach of several patients. In long-term, it ...
(Date:5/6/2015)... , UAE, May 6, 2015 ... management solutions, has been named a "Cool Vendor" by top ... in Emerging Markets 2015". Gartner defines a "Cool ... are innovative, impactful and intriguing. The report highlights ... whose organizations operate in emerging markets should look at local ...
Breaking Medicine Technology:Global Chromatography (Instruments and Reagents) Market 2015 - Forecasts to 2019 2Global Insulin Patch Market Opportunity Analysis 2015 2UAE-Based Software Developer Named by Gartner as a Cool Vendor 2UAE-Based Software Developer Named by Gartner as a Cool Vendor 3UAE-Based Software Developer Named by Gartner as a Cool Vendor 4
Cached News: