HOME >> MEDICINE >> NEWS
Brookhaven Lab and BioSET develop a synthetic peptide that enhances the effect of BMP-2

UPTON, NY Researchers from the U.S. Department of Energy's Brookhaven National Laboratory (BNL) and BioSurface Engineering Technologies, Inc. (BioSET) have developed a synthetic peptide that enhances the effects of a tissue growth factor known as bone morphogenetic protein 2, or BMP-2. BMPs are a family of proteins in the human body responsible for the proliferation, repair, and differentiation of cells in many tissues, including bone.

The researchers designed one portion of the peptide to target the BMP-2 receptor molecules that occur on the surface of bone-forming stem cells and another portion to interact with BioSET's drug-binding agent HepaSilTM, a heparin-based product. The peptide, called B2A2, is one of a series of synthetic analogs of naturally occurring growth factors being developed in the Brookhaven/BioSET collaboration.

This research is reported in the November 8th online version of the Journal of Bone & Mineral Research.

"Our study shows that a small amount of the peptide that we developed increases the effectiveness of BMP-2 as much as 40 times," said Brookhaven scientist Louis Pea, senior author of the paper. "This peptide unlocks a synergy with BMP-2. In a cell culture model, we used BMP at doses too low to have any observable effect by itself, and the same was true for the B2A2 peptide. But when the two were added together in the same low doses, the cells were strongly triggered to develop into bone-forming cells.

"First-generation BMP-impregnated medical devices are currently used clinically for spine repair and to accelerate the healing of long bones," Pea continued. "These devices show effectiveness in inducing bone repair, but there is concern over the high levels of the growth factors that are currently required. An agent that decreases the amount of BMP needed or one that can recruit the body's own growth factors to be more effective could have a substantial clinic
'"/>

Contact: Diane Greenberg
greenb@bnl.gov
631-344-2347
DOE/Brookhaven National Laboratory
9-Nov-2004


Page: 1 2

Related medicine news :

1. Brookhaven spotlights: News from the March 2003 American Chemical Society Meeting
2. Brookhaven lab scientist wins Glenn T. Seaborg Award for Nuclear Chemistry
3. Late developers may run higher risk of infection than sexually mature younger teens
4. Hospital acquired infections present major problem for infants in developing countries
5. Targeting mutant B-Raf protein reduces melanoma development
6. Liverpool to lead 20M Department of Health initiative to develop medicines for children
7. Helping answer needs by developing specialists in autism
8. Common anesthetics appear safe for developing fetal brain
9. UCSD-Utah team develops mouse model to test therapies for macular degeneration
10. Hopkins convenes consensus conference to develop blueprint for nationwide matching program
11. Daily supplement may boost birthweight of babies in the developing world

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2019)... , ... April 18, 2019 , ... She went from ... pair of eyeglasses, said her mother, Cheryl Reilly. Those “goofy tests,” performed by ... Mikayla Reilly, then 12 years old, had such narrow range of visual awareness, she ...
(Date:4/18/2019)... ... April 18, 2019 , ... As cannabis ... Cannabis Industry Report . The study—which considers consumers’ perceptions of, attitudes about, and ... manufacturing, offering insight into what kinds of products consumers want to see. , ...
(Date:4/17/2019)... ATLANTA (PRWEB) , ... April 17, 2019 , ... Kadan ... nearly 35 years, announced today that it has received both the 2019 Best of ... Pulse. These awards are granted only to the top-ranking home care providers, based on ...
(Date:4/17/2019)... SAN DIEGO (PRWEB) , ... April 17, 2019 ... ... supplement created to help reduce hangover symptoms. This California-made supplement was designed ... productive routines. It is now available for purchase via GotPurpleTree.com and ...
(Date:4/17/2019)... , ... April 17, 2019 , ... ... on advances in revolutionary diagnostic technologies. This episode is scheduled to air 3Q ... this segment, Innovations will focus on Credo Biomedical Pte. Ltd. (Credo Biomedical), a ...
Breaking Medicine News(10 mins):
(Date:4/17/2019)... ... April 17, 2019 , ... Stealth ... mitochondrial dysfunction, announced yesterday at the 2019 Muscular Dystrophy Association (MDA) Clinical ... (OLE) clinical trial evaluating efficacy of elamipretide, an investigational product that targets ...
(Date:4/17/2019)... ... April 17, 2019 , ... The Job Research Foundation has ... into the causes of and treatments for Job Syndrome. , The Foundation awarded ... place around the globe in three countries, and on three continents. The recipients are: ...
(Date:4/17/2019)... ... April 17, 2019 , ... Kennywood is making a commitment ... spectrum, have an amazing experience. As part of this commitment, the amusement park ... Board of Credentialing and Continuing Education Standards (IBCCES) to organizations who have completed ...
Breaking Medicine Technology:
Cached News: