HOME >> MEDICINE >> NEWS
Buck researcher makes progress in fight against Huntington's Disease

Novato, CA -- Scientists at the Buck Institute for Age Research have announced a new understanding of how damage occurs in the brains of Huntington's disease patients. The discovery of a "new player" among harmful proteases advances the fight against Huntington's disease, an inherited neurodegenerative disorder. As it progresses, the disease causes uncontrollable movements, rigidity, dementia and death. The most famous victim of Huntington's disease was American folk singer Woody Guthrie.

Lisa Ellerby, Ph.D., who directs a laboratory at the Buck Institute, suggests that the protease calpain could play an important role in Huntington's disease and therefore be a target for drugs designed to slow or stop the progression of brain damage in the disease. Previous work in the field, including studies conducted by Dr. Ellerby, showed that caspases were involved in Huntington's disease progression. Now, she said, it is clear that "a new player from the calpain family" also is implicated.

A protease is a naturally occurring enzyme, which is responsible for the processing of a protein. Calpains are calcium-modulated proteases. Certain proteases have been implicated in the development of neurodegenerative disorders, either directly by killing neurons or indirectly by cleaving proteins into smaller toxic fragments that threaten the survival of neurons. "Previous work on Huntington's disease showed that calcium dysregulation was involved in pathogenesis, and the calpain discovery ties this knowledge together nicely," Dr. Ellerby said.

"This is not the one cause for Huntington's Disease," she added. "The relationship between calpains and Huntington's disease progression will require further work." Both post-mortem disease tissue and cell culture models were used in the study. Design of calpain inhibitors represents a therapeutic drug target for a number of pharmaceutical companies and therefore may represent a viable treatment strategy for the
'"/>

Contact: Elizabeth Eshoo
eeshoo@buckinstitute.org
415-209-2261
Buck Institute for Age Research
19-Jun-2002


Page: 1 2

Related medicine news :

1. U of M researcher says Viagra may cause permanent vision loss in some men
2. Indiana University researchers closer to helping hearing-impaired using stem cells
3. Protein that helps skin cancer spread identified by Stanford researchers
4. US life expectancy about to decline, researchers say
5. Gene for age-related macular degeneration discovered by Yale researchers
6. Dartmouth researchers find where musical memories are stored in the brain
7. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
8. US cancer researchers launch first American-Israeli cancer conference
9. Mayo Clinic researcher calls for improved newborn screening
10. Hard choices: Pitt researcher presents findings on when to accept organ transplants
11. Brain-scanning technologies need standards, according to Stanford researcher

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2016)... ... February 11, 2016 , ... According to an article ... a weight loss dietary supplement, is being recalled due to the discovery that it ... there is not a single supplement on the market proven to help people safety ...
(Date:2/11/2016)... ... February 11, 2016 , ... Dr. ... range of cosmetic procedures. Along with performing procedures, the magazine also highlights that ... many cosmetic procedures. One of the most common procedures he performs is his ...
(Date:2/11/2016)... ... ... The president released a FY 2017 budget request on Tuesday that includes $48.8 ... burden to military beneficiaries. , MOAA’s president, retired Air Force Lt. Gen. Dana ... quantifiable benefit fixes mixed with numerous beneficiary fee hikes. , “We were hoping to ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... dermatology and women’s health, is pleased to announce the promotions of Allison Kelly ... sales team, Steve Catone to executive vice president of North American capital sales, ...
(Date:2/11/2016)... Mount Laurel, NJ (PRWEB) , ... February 11, ... ... Commission) announces the call for nominations seeking candidates for the Board of Commissioners. ... individuals with passion, skills and experience with diversity of clinical practice settings and ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 11, 2016 Transformational M&A achieved through ...   --> Transformational M&A achieved through NPS and ... --> Transformational M&A achieved through NPS and Dyax ... Positioned for future growth with most robust pipeline in Shire ... for future growth with most robust pipeline in Shire ...
(Date:2/11/2016)... Brain Cancer patients in the Mid-South now ... Cancer Center . Optune™, a portable device ... replication causing death of cancer cells, is the first ... a significant extension in overall survival rates for newly ... Center is the only medical center in ...
(Date:2/11/2016)... Jeffrey Zucker , vice president of Feasibility and ... year,s Summit for Clinical Operations Executives (SCOPE), being held Feb. ... Zucker will discuss how sponsors can rebuild and ... Site Study Activation and Performance" portion of the conference. His ... a.m. --> --> In ...
Breaking Medicine Technology:
Cached News: