HOME >> MEDICINE >> NEWS
Buck researcher makes progress in fight against Huntington's Disease

Novato, CA -- Scientists at the Buck Institute for Age Research have announced a new understanding of how damage occurs in the brains of Huntington's disease patients. The discovery of a "new player" among harmful proteases advances the fight against Huntington's disease, an inherited neurodegenerative disorder. As it progresses, the disease causes uncontrollable movements, rigidity, dementia and death. The most famous victim of Huntington's disease was American folk singer Woody Guthrie.

Lisa Ellerby, Ph.D., who directs a laboratory at the Buck Institute, suggests that the protease calpain could play an important role in Huntington's disease and therefore be a target for drugs designed to slow or stop the progression of brain damage in the disease. Previous work in the field, including studies conducted by Dr. Ellerby, showed that caspases were involved in Huntington's disease progression. Now, she said, it is clear that "a new player from the calpain family" also is implicated.

A protease is a naturally occurring enzyme, which is responsible for the processing of a protein. Calpains are calcium-modulated proteases. Certain proteases have been implicated in the development of neurodegenerative disorders, either directly by killing neurons or indirectly by cleaving proteins into smaller toxic fragments that threaten the survival of neurons. "Previous work on Huntington's disease showed that calcium dysregulation was involved in pathogenesis, and the calpain discovery ties this knowledge together nicely," Dr. Ellerby said.

"This is not the one cause for Huntington's Disease," she added. "The relationship between calpains and Huntington's disease progression will require further work." Both post-mortem disease tissue and cell culture models were used in the study. Design of calpain inhibitors represents a therapeutic drug target for a number of pharmaceutical companies and therefore may represent a viable treatment strategy for the
'"/>

Contact: Elizabeth Eshoo
eeshoo@buckinstitute.org
415-209-2261
Buck Institute for Age Research
19-Jun-2002


Page: 1 2

Related medicine news :

1. U of M researcher says Viagra may cause permanent vision loss in some men
2. Indiana University researchers closer to helping hearing-impaired using stem cells
3. Protein that helps skin cancer spread identified by Stanford researchers
4. US life expectancy about to decline, researchers say
5. Gene for age-related macular degeneration discovered by Yale researchers
6. Dartmouth researchers find where musical memories are stored in the brain
7. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
8. US cancer researchers launch first American-Israeli cancer conference
9. Mayo Clinic researcher calls for improved newborn screening
10. Hard choices: Pitt researcher presents findings on when to accept organ transplants
11. Brain-scanning technologies need standards, according to Stanford researcher

Post Your Comments:
(Date:11/24/2014)... November 24, 2014 Mental health ... day. They break up families, ruin careers, and ... hope for those that suffer,” says Hardy ... is showing that our specialized nutritional treatments can ... appear on “Mind Over Matter”, the premiere episode ...
(Date:11/24/2014)... Dr. Michael Kettel , a leading fertility expert ... to discuss egg freezing as a viable and increasingly accessible ... news recently, with new company benefits at Facebook and Apple ... “[The companies] see it as a way to take care ... Says Dr. Kettel. , Up until a few weeks ago, ...
(Date:11/23/2014)... The report, “Market Snapshot: Aesthetic ... - Asia-Pacific” provides quantitative analysis of the three ... invasive body contouring devices, non-invasive body contouring devices ... size data by revenue and volume over the ... Japan, South Korea, Australia and India. It uses ...
(Date:11/23/2014)... News) -- The holidays can be a challenge for ... trigger major meltdowns, an expert says. "Holidays with ... but when you have children with special needs, some ... professor at University of the Sciences in Philadelphia, said ... let your hosts or visitors know what special requirements ...
(Date:11/23/2014)... New York, NY (PRWEB) November 23, 2014 ... over the past month in a federal litigation involving ... over similar diabetes medications, Bernstein Liebhard LLP reports. ... that 566 claims over a class of Type 2 ... been filed in the U.S. District Court, Southern District ...
Breaking Medicine News(10 mins):Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 2Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 3Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 2Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 2Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 4Health News:Holidays Can Be Sensory Overload for Kids With Autism 2Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 2Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 3Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 4
(Date:11/24/2014)...  Marta Rendon, MD, founder of the Rendon Center for ... FL and international key opinion leader in dermatology, was one of ... States to attend the international Aesthetic Experts Summit ... Here, at this gathering of over 600 physicians from 57 ... surgery experts from Asia and ...
(Date:11/24/2014)...  GlySens Incorporated announced today that it has been ... National Institute of Diabetes and Digestive and Kidney Diseases ... (NIH).  The grant is intended to support human clinical ... implantable glucose monitoring system.  Final preparations for launch of ... begin before the end of 2014. "We ...
(Date:11/23/2014)... Calif. , Nov. 23, 2014 Anthera ... that Paul F. Truex , President and Chief ... 2014 Annual Piper Jaffray Healthcare Conference. ... , at the Palace Hotel in New ... Pharmaceuticals Anthera Pharmaceuticals is a biopharmaceutical company ...
Breaking Medicine Technology:Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 2Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 3GlySens Incorporated Awarded $2 Million Grant from the National Institutes of Health 2Anthera Pharmaceuticals to Present at Annual Piper Jaffray Healthcare Conference 2
Cached News: