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Buszaki neuroscience research published in current journals 'Science' & 'Nature'

n the hippocampus. Some of these techniques, and more advanced methods, are part of Buzsaki's recent $1.4 million NIH grant.

$1.4 Million NIH Grant: How Memories Are Formed

The grant from the National Institutes of Health will enable Buzsaki and his co-researchers to further their brain memory research. "The main goal is to understand the formation of memories and the underlying plastic mechanisms in the brain," said Buzsaki. "Current imaging methods such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) do not have either the time or spatial resolution for this task."

Under the NIH grant, the researchers will be taking advantage of the "fast progress in silicon technology and laser-scanning microscopy to directly study the subcellular elements that play a critical role in changing connectivity among neurons and are part of the overall process leading to memory formation," Buzsaki added.

Buzsaki compares the silicon brain probes to earthquake monitoring stations. "To determine the precise position and timing of seismographic activity requires a lot of information from many recording stations to find out what is happening. Similarly, in the brain, multiple monitoring sites at the microscopic level allow researchers to monitor numerous neuronal coalitions to find out what their collective message might be."


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Contact: Helen Paxton
paxton@andromeda.rutgers.edu
973-353-5262
Rutgers, the State University of New Jersey
14-Jun-2002


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