By Losing (Molecular) Weight, A Clot-Dissolving Drug May Be In Better Shape To,,Help People Avoid A Repeat Heart Attack

DALLAS, July 28 -- In the future, people who have had mild heart attacks or suffer from chest pain may be able to inject themselves with a drug at home to prevent a heart attack or episodes of chest pain, say scientists.

In a study and editorial in today's Circulation: Journal of the American Heart Association, researchers say that enoxaparin -- a slimmed-down form of the commonly used clot-dissolving drug heparin -- could help stifle a clot-forming protein that enters the bloodstream after the heart is damaged.

The release of clot-inducing proteins into the bloodstream continues months after chest pain or mild heart attacks. Researchers say people affected could one day fight back with a regular therapy of at-home enoxaparin injections. "It seems logical to not only provide effective anti-clotting therapy during the initial episode of chest pain or just after the heart attack, but to also use that therapy in the months following that event," says the editorial's lead author Elliott Antman, M.D., director, Samuel A. Levine Cardiac Unit, Brigham and Women's Hospital in Boston. "In theory, this new research might allow physicians to prescribe relatively unsupervised long-term self-administration of anti-clotting therapy, sort of an insulin-like injection for coronary artery disease."

By using enoxaparin, researchers were able to control von Willebrand factor, a "reactant" protein released into the bloodstream when blood vessels are inflamed or when a person has a heart attack or chest pain. The scientists found enoxaparin to be superior to heparin in controlling von Willebrand factor. When released into the bloodstream, von Willebrand factor plays the role of traffic cop. It directs platelets -- disk-shaped blood particles that help form clots -- to the damaged area of blood vessels, leading to a particle pile-up that can form blood clots. By suppressing von Willebrand factor, potential clots can be avoided.

Scientists studied which of the "react

Contact: Brian Henry
American Heart Association

Page: 1 2 3

Related medicine news :

1. Losing a job near retirement age significantly increases risk of stroke
2. Losing consciousness can stop you getting posttraumatic stress disorder
3. Losing hostility makes heart patients healthier
4. Innovation prize finalists announced in Science of Better
5. Disaster management: Better management of hospital resources and staff is the answer
6. Better research needed to assess psychological and social effects of cannabis
7. Better predictors are needed for posttraumatic stress disorder in children
8. Better brain imaging helps surgeons avoid damage to language functions
9. Better outcome for ICU patients after removal of bacteria from digestive tract
10. Better care and better communication urgently needed
11. Better access to health care is key to higher survival rates for African-Americans with colon cancer

Post Your Comments:

(Date:8/5/2020)... ... 05, 2020 , ... In its often-heroic ongoing response to ... of the obstacle - shortages of tests, ventilators and ICU beds; strained lab ... postponement of all nonessential services - providers across the country have found new ...
(Date:8/5/2020)... , ... August 05, 2020 , ... ... animal health industry, as president of the largest veterinarian-owned purchasing Cooperative in the ... ANIMALE in various roles where she gained extensive knowledge and experience in the ...
(Date:8/5/2020)... ... August 04, 2020 , ... Total ... Autism Spectrum Disorder (ASD) in Wisconsin, is delighted to announce the grand opening ... opening of their newest center, Total Spectrum now proudly serves ten different locations ...
(Date:8/3/2020)... , ... August 03, 2020 , ... ... will launch its Suite360:Mental Health and Prevention program district-wide, developed to help students ... Trafficking Prevention. , Florida schools and districts must provide their students with ...
(Date:8/3/2020)... ... August 03, 2020 , ... Actuate Therapeutics, Inc. ... with first-line advanced pancreatic cancer in a phase 2 study of 9-ING-41, as ... EudraCT#:2018-003739-32). 9-ING-41 is Actuate’s proprietary small molecule glycogen synthase kinase-3 beta (GSK-3ß) ...
Breaking Medicine News(10 mins):
(Date:8/5/2020)... ... August 04, 2020 , ... Millions of America’s seniors ... health and quality of life unless Congress and the Centers for Medicare & ... (ASHA) warns today. , At issue is CMS’s 2021 proposed Medicare Physician ...
(Date:8/3/2020)... ... August 03, 2020 , ... Seattle’s Infectious ... to amend and restate IDRI’s license with Immune Design, a wholly owned subsidiary ... the amendment, the parties have agreed to modify the licensed fields and indications ...
(Date:8/3/2020)... ... August 03, 2020 , ... LaVoieHealthScience (LHS), an integrated investor and ... Donna L. LaVoie, President, CEO and Founder of LHS, has been named to the ... 2005, the PharmaVOICE 100 has honored more than 1,500 industry executives for their contributions ...
Breaking Medicine Technology:
Cached News: