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C-reactive proteins do not predict early osteoarthritis

is the primary activator of the C-reactive protein gene in the liver. Interestingly, according to Kraus, fat tissue, especially the "bad" fat that collects around the waist, is the major source of IL-6.

"This is what probably accounts for the strong relationship between C-reactive protein and BMI," she said. "We know that exercise has the ability to decrease levels of C-reactive proteins. For this reason, measuring C-reactive protein levels in our osteoarthritis patients who are prescribed exercise may give us useful information about how patients are responding to therapy."

Osteoarthritis is a growing national health issue, with more than 40 million Americans suffering from the disorder, known as the "wear-and-tear" form of arthritis. The other major form, rheumatoid arthritis, occurs when the body's immune system attacks the linings of joints.

It is estimated that more than 70 percent of Americans over the age of 65 show some signs of osteoarthritis, which is characterized by the slow degeneration of the buffering layer of cartilage within joints. It occurs most commonly in knees, hips, hands, neck and the lower back.


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Contact: Richard Merritt
merri006@mc.duke.edu
919-684-4148
Duke University Medical Center
7-Mar-2004


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