HOME >> MEDICINE >> NEWS
CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide

A protein called CK2 plays a deadly role in colorectal carcinoma by blocking the ability of these tumors to activate a natural self-destruct mechanism that would clear this cancer from the body. This finding, by researchers at St. Jude Children's Research Hospital, is currently published in the online edition of Oncogene.

The renegade CK2 protein keeps the tumor alive and growing by desensitizing the cancer cells to the effects of another protein called TRAIL. Normally, TRAIL triggers apoptosis (cell suicide) in the cancer cells as a way of protecting the body. CK2 is an enzyme composed of four small proteins--two alpha proteins and two beta proteins.

The finding holds promise for developing drugs that help a patient's cancer cells become sensitized to TRAIL-induced apoptosis. For example, treating the tumors with TRAIL to trigger apoptosis while blocking CK2 might enhance anti-cancer treatment for a variety of other solid tumors, such as pediatric rhabdomyosarcoma, according to Janet Houghton, Ph.D., a member of St. Jude Hematology-Oncology. Rhabdomyosarcoma is a tumor originating in cells that have some features of muscle cells.

The St. Jude team showed that CK2 exerts its anti-apoptosis effect within a structure called DISC (death-inducing signaling complex). The DISC is a large jumble of proteins that interact with each other after TRAIL binds to the outer cell membrane. After DISC forms, an enzyme called caspase-8 triggers the cascade of biochemical events outside DISC that eventually leads to cell death. By desensitizing the cell to TRAIL, CK2 disrupts the DISC response, which in turn prevents apoptosis and allows the cancer cell to continue growing.

"The work my laboratory has done using our cell lines of colorectal cancer to investigate the role of CK2 in tumors is now bearing fruit," said Houghton, senior author of the Oncogene report. "We've shown in some detail how CK2 helps cancer cells survive the natural tendency for abnormal cell
'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
23-Feb-2005


Page: 1 2 3

Related medicine news :

1. Targeting mutant B-Raf protein reduces melanoma development
2. Mechanism of RNA recoding: New twists in brain protein production
3. Epstein-Barr virus protein crucial to its role in blood cancers
4. Neuronal death and processing of Tau protein in Alzheimers disease
5. Brain synapse formation linked to proteins, Stanford study finds
6. Stat5 protein inhibits spread of breast cancer cells
7. UCSD-Salk team show proteins gene-silencing role in development of nervous system
8. Controversial drug shown to act on brain protein to cut alcohol use
9. New protein discovered by Hebrew University researchers
10. Reduced progression of atherosclerosis tied to statin drugs lowering fats, protein
11. Blood protein predicts risk of heart attack

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/7/2018)... ... September 07, 2018 , ... Modere, a ... a presence worldwide, today announced that its Chief Executive Officer, Asma Ishaq, has ... Ishaq will be presented the award on Friday, September 7, at the Rice ...
(Date:9/2/2018)... ... September 01, 2018 , ... ... HydraFacial MD® Elite to its leading menu of results-driven aesthetic treatments. HydraFacial ... an infusion of clinically-proven ingredients to dramatically improve your skin’s tone and ...
(Date:9/1/2018)... Texas (PRWEB) , ... September 01, 2018 , ... ... event proclaimed by the International Veterinary Academy of Pain Management (IVAPM) that aims ... Veterinary Medical Association (TVMA) is partnering with IVAPM by educating pet owners of ...
(Date:8/31/2018)... ... August 31, 2018 , ... The ... Heart Association (AHA) to be responsive for procurement purposes. , A 100 million ... now reap the benefits. Companies like Pacific Medical Training are already offering VA ...
(Date:8/31/2018)... Calif. (PRWEB) , ... August 31, 2018 , ... ... is pleased to announce the promotion of Nitin Arneja to Chief Information Officer. ... will lead the efforts to develop technology solutions that protect, optimize, scale, and ...
Breaking Medicine News(10 mins):
(Date:9/12/2018)... ... September 13, 2018 , ... Safety ... Sept. 27, 2018 — 1:30 p.m. – 3:00 p.m. ET, http://info.fdanews.com/safety-reporting-in-global-clinical-trials ... by as much as fifty percent. , This can be due to ...
(Date:9/7/2018)... ... 2018 , ... This year, the California Society of Plastic Surgeons (CSPS) awarded ... IMPLANT® - Seven-Year Clinical Trial Results at the 68th CSPS Annual Meeting. Dr. ... (American Society of Plastic Surgeons) meeting in Chicago this fall. , “I am honored ...
(Date:9/7/2018)... ... ... Pastor and Overseer at The House of Yahweh in Abilene, Texas, has written a new ... is undeniable. , Yisrayl scolds mainstream religions for allowing and even promoting the use of ... great meaning in the Name, and to take that away, shows there is an intentional ...
Breaking Medicine Technology:
Cached News: