HOME >> MEDICINE >> NEWS
COX-2 inhibitor could be safest anti-inflammatory drug for older people

A Canadian study involving over 130,000 older people in this week's issue of THE LANCET shows how the anti-inflammatory cyclo-oxygenase-2 (COX-2) inhibitor celecoxib may have a lower risk of congestive heart failure compared with other non-steroidal anti-inflammatory drugs.

Non-selective, non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used by older people to relieve arthritis symptoms, but are associated with an increased risk of congestive heart failure. Less is known about the cardiovascular effects of COX-2 inhibitors, a newer group of NSAIDS.

Muhammad Mamdani from the Institute for Clinical Evaluative Sciences (ICES), Toronto, Canada, and colleagues assessed retrospectively the risk of hospital admission for heart failure for around 14,500 people using the COX-2 inhibitor rofecoxib, around 19,000 using the COX-2 inhibitor celecoxib, and around 5400 people who had been using non-selective NSAIDs. 100,000 people not using NSAIDs were used as a control group.

Compared with non-NSAID users, patients on rofecoxib had an 80% increase in hospital admission for heart failure; people using non-selective NSAIDS had a 40% increased admission risk. However, users of celecoxib had the same rate of hospital admission for heart failure as people who had never used NSAIDs.

Dr Mamdani comments: "our findings suggest significant differences between non-selective NSAIDs and individual COX-2 inhibitors with respect to risk of admission for congestive heart failure. The clinical relevance of these findings, in view of the widespread use of the drugs, warrants the implementation of large-scale randomised controlled trials to examine this issue further".


'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
27-May-2004


Page: 1

Related medicine news :

1. COX-2 inhibitors associated with blood pressure elevation
2. COX-2 product offers good and bad news in test tube strokes
3. COX-2 inhibitor increases the risk of heart attack in elderly adults with no history of heart attack
4. More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
5. Special JAMA commentary on lessons learned from troubles with COX-2 inhibitors
6. NIH halts use of COX-2 inhibitor in large cancer prevention trial
7. Estrogen-associated COX-2 pathways explain protection from heart disease in female mice
8. Lupus discovery may pave way to better-designed COX-2 inhibitors
9. Study findings question COX-2 drug cost effectiveness
10. COX-2 inhibitors and the elderly
11. Aspirins target, the COX-2 enzyme, linked to cancer of the uterus

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2020)... ... May 26, 2020 , ... ... certain infections can impact the brain causing post infectious encephalitis. The work ... Streptococcal Infections) and PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) could adversely attack the ...
(Date:5/26/2020)... ... ... Sex educator, activist, humanitarian, and Wicked Pictures star jessica drake and ... Audio Visual Award for jessica drake's Guide to Wicked Sex: Senior Sex. The collaborative ... in its demonstrations and narratives and was produced and distributed by Wicked Pictures. ...
(Date:5/21/2020)... , ... May 21, 2020 ... ... Companion to the CRC’s Guide to Coordinating Clinical Research, CenterWatch eLearning , ... research management, The CRC Trainer: An Interactive Companion to the CRC’s Guide ...
(Date:5/21/2020)... ... May 21, 2020 , ... Fujirebio Diagnostics, Inc., a consolidated ... announced today that Cigna has added ROMA® (Risk of Ovarian Malignancy Algorithm) to ... dedicated to improving the health, well-being, and peace of mind of the customers ...
(Date:5/21/2020)... ... May 21, 2020 , ... Friends of Lisa Campbell, ... been endorsed by Planned Parenthood Southeast Advocates (PPSEA). PPSEA educates and ... planning and the full range of reproductive health care. PPSEA educates and lobbies on ...
Breaking Medicine News(10 mins):
(Date:5/26/2020)... ... May 26, 2020 , ... Melwood is proud to be donating thousands of ... food pantries, group homes and nursing homes. “It’s more important than ever to reach ... lines and bring a little cheer to seniors and individuals of differing abilities,” said ...
(Date:5/25/2020)... ... May 24, 2020 , ... May is ... electricians, want the public to know what safety resources are available. Every year ... (ESFI) launches an education campaign to inform the public about safety steps that ...
(Date:5/21/2020)... ... May 21, 2020 , ... In today’s news cycle we often hear things ... shake hands with others; to avoid restaurants, movie theaters, concerts, sporting events or schools; ... AppleTV+, YoutubeTV or Prime Video subscriptions. But as things begin to return to normal ...
Breaking Medicine Technology:
Cached News: