HOME >> MEDICINE >> NEWS
COX-2 product offers good and bad news in 'test tube' strokes

Laboratory studies at Johns Hopkins have revealed that certain products of the enzymes COX-1 and COX-2 can both protect and damage the brain. The findings, published in the February 2005 issue of the Journal of Neurochemistry, offer tantalizing clues to why drugs like Vioxx and Celebrex, which block COX-2, can ease arthritis but potentially harm the heart and brain.

Katrin Andreasson, M.D., an assistant professor in the neurology and neuroscience departments at Hopkins, and lead author of the study, explains that the recent discoveries of cardiovascular complications with long-term use of some COX-2 inhibitors are thought to be due to blocking effects of "good" prostaglandins, which are the downstream products of COX activity, potentially leading to heart attacks and strokes. "Defining which prostaglandin pathways are good and which promote disease would help to design more specific therapeutics," she says.

In their latest laboratory studies, the Hopkins scientists discovered that the prostaglandin PGD2 has a protective or harmful effect in the brain depending on where it docks on a brain cell's surface. After brain cells experience the laboratory equivalent of a stroke, PDG2 can protect them from being killed if it binds to one docking point, or receptor, on the cells' surface, but causes them to die in greater numbers if it binds to a second receptor instead, the researchers report. Prostaglandins are involved in a wide variety of bodily activities including relaxation and contraction of muscles and blood vessels, control of blood pressure and inflammation.

"PGD2 is the most-produced prostaglandin in the brain," says Andreasson. "It trumps all of the rest. So we theorized that high levels are protective. But it was a surprise that it was so effective at protecting neurons."

Because the Hopkins team found that PGD2's positive effects generally outweigh its negative ones, the group speculates that PGD2 may provide a potential target
'"/>

Contact: Joanna Downer or Katherine Unger
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
14-Feb-2005


Page: 1 2

Related medicine news :

1. COX-2 inhibitors associated with blood pressure elevation
2. COX-2 inhibitor increases the risk of heart attack in elderly adults with no history of heart attack
3. More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
4. Special JAMA commentary on lessons learned from troubles with COX-2 inhibitors
5. NIH halts use of COX-2 inhibitor in large cancer prevention trial
6. Estrogen-associated COX-2 pathways explain protection from heart disease in female mice
7. COX-2 inhibitor could be safest anti-inflammatory drug for older people
8. Lupus discovery may pave way to better-designed COX-2 inhibitors
9. Study findings question COX-2 drug cost effectiveness
10. COX-2 inhibitors and the elderly
11. Aspirins target, the COX-2 enzyme, linked to cancer of the uterus

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2020)... ... April 04, 2020 , ... MyAdvisor, a holistic wellness technology ... Yellow Ribbon Fund (YRF) to offer mental health and care coordination services to ... partnership to launch a new initiative throughout the global COVID-19 pandemic, MyAdvisor and ...
(Date:4/2/2020)... ... April 02, 2020 , ... FDA CDS ... Tuesday April 7, 2020, 1:30-3:00 p.m. EDT, https://www.fdanews.com/cdssoftwareregulation ... used to guide clinical management of the Coronavirus.* , Is one’s software regulated ...
(Date:4/2/2020)... ... 2020 , ... Representatives fighting for children born exposed ... and guardians, to file a proof of claim in order to qualify to ... available by Purdue as part of its bankruptcy settlement. , “The COVID-19 national ...
(Date:4/1/2020)... , ... April 01, 2020 , ... ... (PPE) to stay safe while treating Coronavirus-infected patients. , Staffers are in particular ... can transmit coronavirus. Earlier this week, The Wall Street Journal reported that New ...
(Date:3/30/2020)... ... 30, 2020 , ... Achieve Medical Center now offers ... comprehensive and compassionate mental health and wellness services in the midst of the ... telemedicine services including initial consultations, evaluations, and follow-up care. It also allows patients ...
Breaking Medicine News(10 mins):
(Date:3/27/2020)... , ... March 27, 2020 , ... ... youth and families, is changing its name to Nexus Family Healing. For more ... hope for youth and families suffering from mental, emotional and behavioral issues. Moving ...
(Date:3/27/2020)... Wash. (PRWEB) , ... March 27, 2020 , ... ... an online college recruitment platform based on students' holistic portfolios, revealed that college-bound ... COVID-19 pandemic. This pandemic is creating huge new barriers to high school senior’s ...
(Date:3/27/2020)... ... March 27, 2020 , ... PTS Diagnostics, a U.S.-based manufacturer ... as President and Chief Executive Officer. , Mr. Chapman brings 20 years of ... ARKRAY USA, Inc. He joins PTS Diagnostics with an accomplished track record regarding ...
Breaking Medicine Technology:
Cached News: