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CREST study finds cilostazol reduces restenosis by almost 40 percent

nt, where restenosis was reduced from 37 percent to 16.9 percent, is particularly exciting."

Dr. Douglas and co-investigators William Weintraub, MD, Director of the Emory Center for Outcomes Research and David Holmes, MD, of the Mayo Clinic, directed CREST, a multicenter, randomized, double-blind, placebo-controlled trial with 705 patients enrolled at 19 clinical sites across the U.S. Patients received standard therapy of aspirin and clopidogrel (which prevents clot formation) plus cilostazol (a phosphodiesterase III inhibitor) or placebo after successful coronary stent implantation. Treatment with study medication (cilostazol or placebo) was continued for six months, when coronary angiography was performed to determine the presence of restenosis. In addition to renarrowing, careful attention was paid to complications, costs, and quality of life issues.


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Contact: Sherry Baker
emoryheartnews@aol.com
404-377-1398
Emory University Health Sciences Center
9-Nov-2003


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