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CRESTOR leads in 1st international prospective study of statins in the metabolic syndrome

as defined by the US NCEP ATP III) and raised LDL-C show:
  • CRESTOR 10mg reduces LDL-C significantly more than atorvastatin 10mg at six weeks (-42% and -36%, respectively; p<0.001)1
  • CRESTOR 20mg reduces LDL-C significantly more than atorvastatin 20mg at 12 weeks (-49% vs -43%, respectively; p<0.001)1
  • CRESTOR 10mg significantly increases HDL-C by 9.3% at six weeks, almost double that of atorvastatin 10mg, which raised HDL-C by 4.8% (p<0.01)1 and CRESTOR 20mg increases HDL-C significantly more than atorvastatin 20mg at 12 weeks (10.5% vs 5.7%, respectively; p<0.01).1
  • CRESTOR 10mg and 20mg are as effective as atorvastatin 10mg and 20mg at lowering patients' triglyceride levels (-19% vs -20% at six weeks and -24% vs -24% at 12 weeks, respectively; n.s.).1

    Lead investigator of the COMETS study, Professor Stalenhoef of University Medical Centre Nijmegen, The Netherlands, comments, "With the number of people with the metabolic syndrome increasing, results such as these for CRESTOR are welcomed by the medical community as here we see a treatment that both lowers LDL-C (a key cardiovascular risk factor) with the added benefit of raising HDL-C."

    New data from the MERCURY I study in a subset of 547 patients with type 2 diabetes were also presented at the EASD this week showing that CRESTOR 10mg reduces LDL-C in patients with type 2 diabetes and dyslipidaemia significantly more than atorvastatin at the same dose (47% vs 37%, respectively: p<0.0001).9 In addition, CRESTOR achieves a significantly greater reduction in non-HDL-C compared to atorvastatin (-42% vs -33%, respectively: p<0.0001) and increases HDL-C. 9

    People with type 2 diabetes are three times more likely to die from a heart attack or stroke than people without diabetes with the same cholesterol level and up to 80% of people with type 2 diabetes die from cardiovascular disease.10,11 Rece
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    • Contact: Rachael Wood
    rachael.wood@astrazeneca.com
    44-162-551-9514
    Shire Health International
    6-Sep-2004


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