Despite more than 30 years of clinical trials, uncertainty has existed regarding the optimal use of antihypertensive drugs in patients with coronary artery disease (CAD), according to background information in the article.
Steven E. Nissen, M.D., of the Cleveland Clinic Lerner School of Medicine, Cleveland, and colleagues examined the effects of antihypertensive drugs in 1,991 patients with CAD and normal blood pressure in the Comparison of Amlodipine vs. Enalapril to Limit Occurrences of Thrombosis (CAMELOT) study, a double-blind, randomized, multicenter 24-month trial (enrollment April 1999-April 2002). Patients received either the calcium channel blocker amlodipine (10 mg); the angiotensin-converting enzyme (ACE) inhibitor enalapril (20 mg); or placebo. In addition, a subset of 274 patients underwent serial intravascular ultrasound (IVUS) examinations to determine if either or both medications reduced the progression of atherosclerosis.
The primary end point was the time to first occurrence of an adverse cardiovascular event such as cardiovascular death, nonfatal heart attack, coronary revascularization, hospitalization for angina pectoris, hospitalization for congestive heart failure, fatal or nonfatal stroke, or diagnosis of vascular disease.
The researchers found that for patients with a baseline systolic blood pressure averaging only 129/78 mm Hg, amlodipine reduced blood pressure an average of 5/3 mm Hg and compared to placebo, produced a 31 percent relative reduction (6.5 percent absolute reduction; 23.1 percent event-rate for placebo, 16.6 percent event rate for amlodipine) in cardiovascular
Contact: Alicia Sokol
JAMA and Archives Journals