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Calcium channel blocker reduces adverse cardiovascular events in certain patients

events. "The number needed to treat for amlodipine is 16, i.e., for every 16 patients who receive amlodipine, there will be on average 1 adverse cardiovascular event avoided during the 2-year period compared with patients who receive placebo," the authors write. "Enalapril treatment also reduced blood pressure by an average of 5/2 mm Hg. However, the observed 15.3 percent relative reduction compared to placebo (2.9 percent absolute reduction; 20.2 percent event rate in the enalapril group) in cardiovascular events was not statistically significant."

The IVUS substudy showed evidence of slowing of progression of coronary artery atherosclerosis with amlodipine.

" the current study provides important new findings regarding the administration of antihypertensive agents to patients with CAD and a 'normal' blood pressure," the researchers write. "These results suggest that the optimal blood pressure range for patients with CAD may be substantially lower than indicated by current guidelines."


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Contact: Alicia Sokol
216-445-9661
JAMA and Archives Journals
9-Nov-2004


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