HOME >> MEDICINE >> NEWS
Canadian discovery promises treatment for HIV dementia

VANCOUVER, CANADA -- Millions of HIV patients who suffer from dementia now have hope of a treatment, thanks to a breakthrough discovery by Canadian researchers.

Scientists from the University of Calgary in Alberta and the University of British Columbia in Vancouver have found that HIV triggers an enzyme in white blood cells that kills nerve cells in the brain. The enzyme, known as Metalloproteinase-2 or MMP2, changes a molecule required for normal brain growth and function. The altered molecule becomes highly toxic and destroys brain nerve cells, giving rise to symptoms of dementia.

It is the first study to unravel the mechanics of how dementia and memory loss is caused in HIV patients. In addition, the researchers also found they could block the toxic effects of MMP2 by using drugs already in clinical trials for cancer treatment.

"We now understand how this enzyme becomes a killing machine," says Christopher Overall, Canada Research Chair in Metalloproteinase Biology at UBC. "This is exciting news for patients because we think dementia can be slowed or stopped by adding another protease blocker to the drug cocktails now used to treat HIV."

More than 20 per cent of people with AIDS experience dementia during the course of their illness. A rapidly progressive condition, HIV dementia is characterized by impaired concentration and problem solving, forgetfulness, as well as motor abnormalities such as slurred speech and difficulties with movement.

The findings of the two-year study, completed with principal co-investigator Christopher Power of the University of Calgary, were reported recently in Nature Neuroscience. Members of Overall's lab at the UBC Faculty of Dentistry completed biochemical assays and identified the toxic protein that allowed Power, a neurologist who treats people with HIV dementia, to test MMP2 on HIV-infected cells.

"The team and I are revved up about the new avenues of potential treatment for pe
'"/>

Contact: Hilary Thomson
hilary.thomson@ubc.ca
604-822-2644
University of British Columbia
5-Nov-2003


Page: 1 2

Related medicine news :

1. U of T researchers describe Joe Canadian tongue
2. Canadian neurologist wins highest award as American Stroke Association honors five
3. Canadian researchers important discovery in HIV research
4. Impact of 2002 Canadian forest fires felt 700 miles away in Baltimore, Maryland
5. Canadian researchers to develop smart drug to repair psychiatric disorders
6. McMaster named Canadian Research University of the Year
7. Safety of Canadian hospitals
8. Patient safety study provides first national estimate of adverse events in Canadian hospitals
9. Canadian doctors dont know costs of prescribed treatments
10. New Canadian study demonstrates clear survival benefit of treatment in trials and at large centres
11. Most Canadian hospitals below recommended standards

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Canadian discovery promises treatment for HIV dementia

(Date:3/3/2015)... (PRWEB) March 03, 2015 eMedEvents, ... and continuing medical education (CME) credit information, has ... for doctors was initially launched in the United ... of its kind in the field of healthcare ... launch of this Denver, Colorado-based start-up company was ...
(Date:3/3/2015)... March 03, 2015 Venato, a ... announced that their flagship software solution now provides ... to be uploaded to the National Healthcare Safety ... Medicaid Services (CMS) require that hospitals submit healthcare ... no later than May 15 for each influenza ...
(Date:3/3/2015)... 03, 2015 Volpara Solutions, leaders in ... John D. Pavlidis has joined their Board of Directors. ... and executive management experience in the medical industry, including ... small organizations. , “John’s broad management experience in breast ... will be a tremendous asset to the sales, product ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 A recent ... confirms what water advocate and radio host Sharon Kleyne ... – lack of sufficient water in the body – ... as 90 percent of the US population. Kleyne further ... a factor in nearly all disease, including aging and ...
(Date:3/3/2015)... TX (PRWEB) March 03, 2015 ... Schumaker, RN, BSN, MBA, CEN, CPHQ, FABC as the ... to clinically-focused innovation for unscheduled, episodic care. ... care, making episodic care settings including urgent care and ... segments in healthcare,” said Roger Davis, T-System’s chief executive ...
Breaking Medicine News(10 mins):Health News:eMedEvents Launches Online Medical Conference, Speaker and CME Platform in India 2Health News:Venato Incorporates Automated NHSN Reporting Tool to Their Software Solution 2Health News:Volpara Solutions Adds Medical Imaging Veteran John Pavlidis to Board of Directors 2Health News:Volpara Solutions Adds Medical Imaging Veteran John Pavlidis to Board of Directors 3Health News:Study linking dehydration and stroke severity supports fresh water advocate’s warnings 2Health News:Study linking dehydration and stroke severity supports fresh water advocate’s warnings 3Health News:T-System Renews Commitment to Clinically-Driven Innovation and Appoints Industry Leader as CNO 2Health News:T-System Renews Commitment to Clinically-Driven Innovation and Appoints Industry Leader as CNO 3
(Date:3/3/2015)... 3, 2015   Mary,s Medicinals today announced ... for the legal-cannabis community with the latest nutritional science ... supplement line enriched with Cannabidiol (CBD) and other ... looking for accurately dosed, cleanly delivered CBD treatments. Due ... cannabis products out of Colorado . ...
(Date:3/3/2015)... , March 3, 2015 Men with ... the prostate is enlarged but not cancerous, have ... invasive and has fewer complications than other minimally ... prostate and surgical options, according to research presented ...  (SIR,s) Annual Scientific Meeting . Using an ...
(Date:3/3/2015)... 3, 2015 Although lung cancer is the ... are only 18 drugs in the market for its ... are nearing their patent expiry in 2015 and 2017 ... vast potential that drug manufacturers are vying to tap ... cell lung cancer (SCLC) and non-small cell lung cancer ...
Breaking Medicine Technology:Mary's Medicinals Unveils Mary's Nutritionals, a Nationally Available Line of Wellness Supplements Enriched with CBD and Plant Nutrients 2Mary's Medicinals Unveils Mary's Nutritionals, a Nationally Available Line of Wellness Supplements Enriched with CBD and Plant Nutrients 3Interventional radiology offers new treatment for enlarged prostates 2Interventional radiology offers new treatment for enlarged prostates 3Interventional radiology offers new treatment for enlarged prostates 4Targeted Lung Cancer Therapies Are Supplanting Conventional Treatments 2Targeted Lung Cancer Therapies Are Supplanting Conventional Treatments 3
Cached News: