HOME >> MEDICINE >> NEWS
Canadian discovery promises treatment for HIV dementia

VANCOUVER, CANADA -- Millions of HIV patients who suffer from dementia now have hope of a treatment, thanks to a breakthrough discovery by Canadian researchers.

Scientists from the University of Calgary in Alberta and the University of British Columbia in Vancouver have found that HIV triggers an enzyme in white blood cells that kills nerve cells in the brain. The enzyme, known as Metalloproteinase-2 or MMP2, changes a molecule required for normal brain growth and function. The altered molecule becomes highly toxic and destroys brain nerve cells, giving rise to symptoms of dementia.

It is the first study to unravel the mechanics of how dementia and memory loss is caused in HIV patients. In addition, the researchers also found they could block the toxic effects of MMP2 by using drugs already in clinical trials for cancer treatment.

"We now understand how this enzyme becomes a killing machine," says Christopher Overall, Canada Research Chair in Metalloproteinase Biology at UBC. "This is exciting news for patients because we think dementia can be slowed or stopped by adding another protease blocker to the drug cocktails now used to treat HIV."

More than 20 per cent of people with AIDS experience dementia during the course of their illness. A rapidly progressive condition, HIV dementia is characterized by impaired concentration and problem solving, forgetfulness, as well as motor abnormalities such as slurred speech and difficulties with movement.

The findings of the two-year study, completed with principal co-investigator Christopher Power of the University of Calgary, were reported recently in Nature Neuroscience. Members of Overall's lab at the UBC Faculty of Dentistry completed biochemical assays and identified the toxic protein that allowed Power, a neurologist who treats people with HIV dementia, to test MMP2 on HIV-infected cells.

"The team and I are revved up about the new avenues of potential treatment for pe
'"/>

Contact: Hilary Thomson
hilary.thomson@ubc.ca
604-822-2644
University of British Columbia
5-Nov-2003


Page: 1 2

Related medicine news :

1. U of T researchers describe Joe Canadian tongue
2. Canadian neurologist wins highest award as American Stroke Association honors five
3. Canadian researchers important discovery in HIV research
4. Impact of 2002 Canadian forest fires felt 700 miles away in Baltimore, Maryland
5. Canadian researchers to develop smart drug to repair psychiatric disorders
6. McMaster named Canadian Research University of the Year
7. Safety of Canadian hospitals
8. Patient safety study provides first national estimate of adverse events in Canadian hospitals
9. Canadian doctors dont know costs of prescribed treatments
10. New Canadian study demonstrates clear survival benefit of treatment in trials and at large centres
11. Most Canadian hospitals below recommended standards

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/25/2016)... ... May 25, 2016 , ... For more than fifty years, we've suffered whiplash as each new ... to conform to the latest nutritional advice – advice that was supposed to keep us ... 2 in 3 American adults are considered to be overweight and more than 1 in ...
(Date:5/25/2016)... ... May 25, 2016 , ... Researchers from SUNY State College of ... their work on visual evoked potential and human attention. The article, VEP and ... Diopsys® NOVA™ ERG and VEP Vision Testing System (Diopsys, Inc., Pine Brook, ...
(Date:5/25/2016)... ... May 25, 2016 , ... Stern Environmental Group , of Secaucus, New ... branded as Stern’s Real Time Monitoring (RTM) Device. Stern Environmental Group will ... motel industry, colleges for use in dormitories, shelters, and nursing homes for real time ...
(Date:5/24/2016)... TN (PRWEB) , ... May 24, 2016 , ... ... group, announces its inaugural health care blockchain event, Distributed: Health, to be held ... in Nashville’s downtown Symphony Center. , A 24-hour Hackathon preceding the event will ...
(Date:5/24/2016)... Michigan (PRWEB) , ... May 24, 2016 , ... ... Nurse Midwife, Roberta Jordan. , Roberta Jordan is a Certified Nurse Midwife ... Grand Valley State University and then went on to complete her masters degree ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)...   , Study met ... bowel cleansing and superiority in , ... of the ascending colon   ... Norgine B.V. today announced new positive data from the phase ... preparation) versus standard 2 litre PEG with ascorbate. The study met ...
(Date:5/24/2016)... joined VMS BioMarketing as senior vice president of sales, announced Andrea Heslin Smiley ... lead the company,s business development and sales team, exploring new opportunities for VMS to ... http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
(Date:5/24/2016)... Dutch surgeons have launched a ground-breaking medical ... and treat patients on a global scale. Medical professionals from ... Asia and the US have already signed up for ... in a totally secure environment. Education  "Imagine ... together with a surgeon at Harvard to treat a bomb victim ...
Breaking Medicine Technology:
Cached News: