HOME >> MEDICINE >> NEWS
Canadian discovery promises treatment for HIV dementia

VANCOUVER, CANADA -- Millions of HIV patients who suffer from dementia now have hope of a treatment, thanks to a breakthrough discovery by Canadian researchers.

Scientists from the University of Calgary in Alberta and the University of British Columbia in Vancouver have found that HIV triggers an enzyme in white blood cells that kills nerve cells in the brain. The enzyme, known as Metalloproteinase-2 or MMP2, changes a molecule required for normal brain growth and function. The altered molecule becomes highly toxic and destroys brain nerve cells, giving rise to symptoms of dementia.

It is the first study to unravel the mechanics of how dementia and memory loss is caused in HIV patients. In addition, the researchers also found they could block the toxic effects of MMP2 by using drugs already in clinical trials for cancer treatment.

"We now understand how this enzyme becomes a killing machine," says Christopher Overall, Canada Research Chair in Metalloproteinase Biology at UBC. "This is exciting news for patients because we think dementia can be slowed or stopped by adding another protease blocker to the drug cocktails now used to treat HIV."

More than 20 per cent of people with AIDS experience dementia during the course of their illness. A rapidly progressive condition, HIV dementia is characterized by impaired concentration and problem solving, forgetfulness, as well as motor abnormalities such as slurred speech and difficulties with movement.

The findings of the two-year study, completed with principal co-investigator Christopher Power of the University of Calgary, were reported recently in Nature Neuroscience. Members of Overall's lab at the UBC Faculty of Dentistry completed biochemical assays and identified the toxic protein that allowed Power, a neurologist who treats people with HIV dementia, to test MMP2 on HIV-infected cells.

"The team and I are revved up about the new avenues of potential treatment for pe
'"/>

Contact: Hilary Thomson
hilary.thomson@ubc.ca
604-822-2644
University of British Columbia
5-Nov-2003


Page: 1 2

Related medicine news :

1. U of T researchers describe Joe Canadian tongue
2. Canadian neurologist wins highest award as American Stroke Association honors five
3. Canadian researchers important discovery in HIV research
4. Impact of 2002 Canadian forest fires felt 700 miles away in Baltimore, Maryland
5. Canadian researchers to develop smart drug to repair psychiatric disorders
6. McMaster named Canadian Research University of the Year
7. Safety of Canadian hospitals
8. Patient safety study provides first national estimate of adverse events in Canadian hospitals
9. Canadian doctors dont know costs of prescribed treatments
10. New Canadian study demonstrates clear survival benefit of treatment in trials and at large centres
11. Most Canadian hospitals below recommended standards

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... Miss. (PRWEB) , ... August 31, 2020 , ... ... (GCPP) recently donated 1,400 N95 face masks to medical first responders across the ... continued to make donations of personal protective equipment (PPE) medical centers , ...
(Date:8/31/2020)... , ... August 31, 2020 , ... The pandemic and topsy-turvy economic outlook continues to ... budgets and look for ways to trim the fat from our monthly expenses and put ... but it’s also important that you have a financial safety net in place in case ...
(Date:8/29/2020)... ... August 29, 2020 , ... When professor and author Randy Pausch was ... most people would. Rather than become melancholic, however, he put together a final lecture ... dreams. Randy Pausch took a negative situation and turned it into something that inspired ...
(Date:8/28/2020)... ... ... Integrated Viral Protection (IVP Air) today announced that the True North Classical ... Indoor Air Protection System that is the first system designed and proven to catch ... the filtration system on September 8th. , The IVP Air S1 model is ...
(Date:8/27/2020)... MORRISTOWN, N.J. (PRWEB) , ... August 27, 2020 ... ... has continued to partner with Evolution Labs to provide their students with Suite360:Mental ... issues related to Mental Health, Substance Abuse and Child Trafficking Prevention. , Florida ...
Breaking Medicine News(10 mins):
(Date:8/28/2020)... ... 2020 , ... Cano Health, LLC, a leading population health ... Antonio is happy to announce that it has selected Tejano musician Jay Perez ... will serve as community advisor, advertising talent, and creative consultant for Cano Health, ...
(Date:8/27/2020)... (PRWEB) , ... August 27, 2020 , ... Austin Oral ... – is pleased to announce Dr. David Szalay, DDS, MD, has joined the practice. ... patients in the new Pflugerville office, which is scheduled to open this fall. The ...
(Date:8/27/2020)... FORT MYERS, Fla. (PRWEB) , ... August 27, 2020 , ... ... its Board of Directors. Dr. Friedman is an adult and pediatric neuro-oncologist who serves ... Duke University and as an educator at Duke University Medical School. , Internationally recognized, ...
Breaking Medicine Technology:
Cached News: