HOME >> MEDICINE >> NEWS
Cancer cells can compress blood vessels, block entry of drugs

A growing tumor needs an increased blood supply for its proliferating cells. But the implications of tumor-related angiogenesis the growth of new blood vessels are much more complex than many investigators have realized. Although these new vessels are required to nourish the tumor itself, they are disorganized and abnormal and can actually block therapeutic agents from reaching malignant cells.

In the Feb. 19 issue of Nature, researchers from Massachusetts General Hospital (MGH) describe how proliferating cancer cells compress both blood and lymphatic vessels within tumors. The findings suggest new strategies for improving the success of cancer treatment. Related studies in the February issue of Nature Medicine provide more information about improving the delivery of anticancer drugs to tumor cells.

"We've known for several years that internal pressure can make it difficult for many drugs to penetrate into a tumor," says Rakesh Jain, PhD, director of the Edwin Steele Laboratory in the MGH Department of Radiation Therapy, senior author of the Nature and Nature Medicine papers. "Much of our work has focused on fluid pressure within tumors, but this was the first look at solid pressure."

As described in the Nature study, fluid pressure had been assumed to be the force compressing vessels within tumors, but actual fluid pressures inside both tumors and their blood vessels are almost equal. The MGH team investigated whether solid pressure exerted by proliferating cancer cells could compromise blood supply in the same way that stepping on a hose cuts off the flow of water. Using human tumors implanted in mice, the researchers administered diphtheria toxin, which kills tissue from humans but not from mice, to selectively destroy cancer cells.

Analysis of the toxin-treated tumors found that both blood vessels and lymphatic vessels looked much more open than did vessels from untreated tumors, which were largely collap
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
18-Feb-2004


Page: 1 2 3

Related medicine news :

1. Cancer in patients with hepatitis C
2. Olson family donates $1 million to Arizona Cancer Center
3. Cancer vaccines: A two-pronged attack?
4. Mayo Clinic Cancer Center receives SPORE grant for brain cancer research from NCI
5. ESMO and Imedex announce partnership for the World Congress on Gastrointestinal Cancer
6. UT Southwestern Moncrief Cancer Center is first in Texas to treat patients with TomoTherapy
7. Cancer researchers seek to predict tumor growth
8. UGA professor receives $3 million grant from National Cancer Institute for breast cancer research
9. Cancer patients in Europe unite with doctors
10. Fox Chase Cancer Center researchers identify novel target for detecting ovarian cancer in blood
11. Cancer burden seen even many years after diagnosis

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cancer cells can compress blood vessels block entry drugs

(Date:1/22/2015)... 2015 AngelWeddingDress, the premier women’s dress ... wedding dresses. View website of AngelWeddingDress.com to ... maternity wedding dresses online for a bridal party. AngelWeddingDress ... quality for them. Its maternity wedding dresses are specially ...
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post explaining ... policy . , Auto insurance quotes help many drivers ... longer necessary to call an agent or visit an agency ... a single website: http://autocarinsurancebest.com/ . , Every business who ...
(Date:1/22/2015)... 2015 Yesterday, Senator Holly Mitchell ... Kristin Olsen (R-Modesto) were honored by the California ... biotechnology, biomedical science, medical device and pharmaceutical innovation ... the “2014 Life Sciences Champion” award from CHI ...
(Date:1/22/2015)... January 22, 2015 EBSCO Information Services ... are expanding their relationship in an effort to further promote ... world. While EBSCO has long made AMA journals available via ... agent for The JAMA Network. , Long known ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Step into ... at the Science Museum of Virginia. Wicked Plants, the ... Wicked Plants unearths 75 poisonous, carnivorous and diabolical plants ... each room to uncover the biochemical, physical and neurological ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Wicked Plants are taking over the Science Museum of Virginia 2
(Date:1/23/2015)... , Jan. 23, 2015  HyGreen, Inc., a leader in ... partnership with RCA Medical, a subsidiary of Ascendis Health ... Each year, hundreds of millions of patients ... as organisms are transmitted from patient to patient via ...
(Date:1/23/2015)... , Jan. 23, 2015  Lixte Biotechnology Holdings, Inc. (OTCQB: ... Phase I trial of Lixte,s lead compound, LB‑100, is being ... John S. Kovach , M.D., the founder and ... to be completed at a single site. Accrual of patients, ...
(Date:1/23/2015)... , Jan. 23, 2015  CytoSorbents Corporation (NASDAQ ... its CytoSorb® extracorporeal cytokine adsorber to reduce deadly ... the receipt of $385,642, net of transaction costs, ... the Technology Business Tax Certificate Transfer Program sponsored ...
Breaking Medicine Technology:HyGreen Partners with RCA Medical in Johannesburg, South Africa 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 3CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3
Cached News: