HOME >> MEDICINE >> NEWS
Cancer drug proves effective in treating sickle cell disease

Researchers at the University of Illinois at Chicago College of Medicine have demonstrated that a drug long used to treat cancer is also effective in combating sickle cell disease.

The drug, called decitabine, works even in patients who don't respond to hydroxyurea, the standard treatment, and appears to produce fewer side effects.

"The results of our study are compelling," said Joseph DeSimone, professor of hematology and oncology and a member of the UIC Cancer Center. "Clearly, decitabine is an effective therapy for patients who do not benefit from the traditional treatment. It is possibly even an improvement, although more studies will have to be done."

The clinical trial was conducted at the University of Illinois Medical Center at Chicago, which houses the area's only clinic specializing in sickle cell disease. Results of the study will appear in the June 1 issue of the scientific journal Blood.

Sickle cell disease is caused by a single mutation in a gene that manufactures hemoglobin, the molecule in red blood cells that delivers oxygen to tissues throughout the body.

The defective form of hemoglobin, called hemoglobin S (for sickle), causes serious health problems. Red blood cells take on a characteristic crescent, or sickle, shape and stick to blood vessel walls.

As a result, the cells cannot squeeze through capillaries. Blood supply is blocked, depriving tissues and organs of oxygen and causing short- and long-term damage. Patients suffer episodes of intense pain, typically in the arms, legs and back, but also in the liver, kidney and abdomen.

In some severe cases, transfusions may be required because the aberrant red blood cells have a much shorter life span than normal red blood cells (10 days vs. 100) and the body can't manufacture enough new red blood cells to keep up, leading to anemia.

Patients may also suffer what is called acute chest syndrome, a particularly serious complication and th
'"/>

Contact: Sharon Butler
sbutler@uic.edu
312-355-2522
University of Illinois at Chicago
17-May-2002


Page: 1 2 3

Related medicine news :

1. Cancer in patients with hepatitis C
2. Olson family donates $1 million to Arizona Cancer Center
3. Cancer vaccines: A two-pronged attack?
4. Mayo Clinic Cancer Center receives SPORE grant for brain cancer research from NCI
5. ESMO and Imedex announce partnership for the World Congress on Gastrointestinal Cancer
6. UT Southwestern Moncrief Cancer Center is first in Texas to treat patients with TomoTherapy
7. Cancer researchers seek to predict tumor growth
8. UGA professor receives $3 million grant from National Cancer Institute for breast cancer research
9. Cancer patients in Europe unite with doctors
10. Fox Chase Cancer Center researchers identify novel target for detecting ovarian cancer in blood
11. Cancer burden seen even many years after diagnosis

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cancer drug proves effective treating sickle cell disease

(Date:3/28/2015)... (PRWEB) March 28, 2015 Designers and ... new overlay entitled Scratches 5K from Pixel Film Studios. ... effects to any media inside Final Cut Pro X” ... Corporate saves time and is an effective tool for ... FCPX Overlay Scratches 5K's intuitive grunge overlays. Simply drag ...
(Date:3/28/2015)... LTW Cyber is an innovation hub ... the purpose of addressing the needs of the global ... own opportunities to grow while seeking collaborative opportunities with ... , Ventures in LTW Cyber focus on secure application ... identifying vulnerabilities and analyzing open source. As the ...
(Date:3/27/2015)... Tampa, FL (PRWEB) March 27, 2015 Florida ... Bay Storm as the team’s exclusive health care provider for ... care provider, Florida Hospital provides medical care and an athletic ... Bay Storm will kick off its season against the Cleveland ... , “This partnership is extremely important to us as ...
(Date:3/27/2015)... 2015 Top medical tourism firm, ... to the Dominican Republic to benefit from the experience ... turning the medical tourism industry upside-down and becoming a ... trustworthy services becoming the central influence. , “Trust ... Patients are not only attracted to low-cost surgical enhancement, ...
(Date:3/27/2015)... Dallas, TX (PRWEB) March 27, 2015 ... Landscape – Germany” is an essential source of ... and reimbursement landscape in Germany. Germany’s increasingly elderly ... drivers of its pharmaceutical market. In 2013, the ... expected to increase at Compound Annual Growth Rate ...
Breaking Medicine News(10 mins):Health News:Pixel Film Studios Unveiled Scratches 5k for Final Cut Pro X Editors 2Health News:Canadian Cybersecurity Ventures Globalize as a Collective 2Health News:Canadian Cybersecurity Ventures Globalize as a Collective 3Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 2Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 3Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 2Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 3Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 2Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 3Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 4
(Date:3/27/2015)... 27, 2015 Concord Medical Services Holdings ... CCM ), a leading specialty hospital management solution ... radiotherapy and diagnostic imaging centers in ... a purchase agreement under which Concord Medical Services ... the Company, agreed to acquire the Fortis Surgical ...
(Date:3/26/2015)... , March 26, 2015  The Burzynski Research ... study independently conducted by the Department of Surgery ... Japan have been published. The study, ... hepatic arterial infusion as post-operative adjuvant therapy with ... of the liver. A total ...
(Date:3/26/2015)... March 26, 2015 Huntington Memorial Hospital is ... perform transcatheter aortic valve replacement (TAVR), a minimally invasive ... revolutionary new way to replace an aortic valve without ... lung machine. The procedure is performed by ... Azhil ( Alex) Durairaj , MD, interventional cardiologist and ...
Breaking Medicine Technology:Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 2Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 3Huntington Memorial Hospital Performs Groundbreaking Minimally Invasive Replacement of Heart Valves 2
Cached News: