HOME >> MEDICINE >> NEWS
Cancer vaccines: A two-pronged attack?

(Brussels, January 17th) The latest findings in cancer vaccine development suggest that cancer vaccines may have two modes of action; specific immunization and non-specific activation of immune cells paralyzed by the tumor.

The human immune system fights cancer partly through the production of many populations of specialized immune cells called cytolytic T cells (CTL). Each CTL population recognizes a different, specific marker, an 'antigen', on the cancer cell surface. Cancer vaccines are designed to tip the balance in favor of the immune system by stimulating the production of CTLs against the particular antigen in the vaccine. However, in back-to-back articles published today in the Journal of Experimental Medicine, investigators at the Brussels Branch of the Ludwig Institute for Cancer Research (LICR) and Brussel's Louvain University have shown that a cancer vaccine not only specifically stimulates the production of CTLs against the vaccine antigen, it also non-specifically activates spontaneously produced CTL populations against multiple cancer antigens.

According to Dr. Thierry Boon, the Director of the LICR Brussels Branch, this observation opens a new way of thinking about how cancer vaccines might work. "We have always thought that cancer vaccines could only be effective if massive numbers of vaccine-specific CTLs were produced. But it seems that, in about 10% of patients with metastatic melanoma, the vaccine might actually be reawakening different CTL populations that have been effectively deactivated by the tumor."

The research team also found that metastases were enriched with inactive CTLs, and they are now assessing exactly how vaccination can 'spark' the reactivation of CTLs. "We believe that these CTLs in the metastatic lesions could potentially eliminate the bulk of the tumor," says Dr. Boon. "Now we have to elucidate why this non-specific process works in some patients and not in others, and then to learn how to harness t
'"/>

Contact: Sarah L. White
swhite@licr.org
1-212-450-1543
Ludwig Institute for Cancer Research
17-Jan-2005


Page: 1 2

Related medicine news :

1. Cancer in patients with hepatitis C
2. Olson family donates $1 million to Arizona Cancer Center
3. Mayo Clinic Cancer Center receives SPORE grant for brain cancer research from NCI
4. ESMO and Imedex announce partnership for the World Congress on Gastrointestinal Cancer
5. UT Southwestern Moncrief Cancer Center is first in Texas to treat patients with TomoTherapy
6. Cancer researchers seek to predict tumor growth
7. UGA professor receives $3 million grant from National Cancer Institute for breast cancer research
8. Cancer patients in Europe unite with doctors
9. Fox Chase Cancer Center researchers identify novel target for detecting ovarian cancer in blood
10. Cancer burden seen even many years after diagnosis
11. Cancer cell detection technology wins Kaye Award for Hebrew University researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2019)... ... August 15, 2019 , ... Jon O'Brien, president of Catholics ... clinics to provide written assurance that they will comply with the Trump Administration’s ... Gag Rule, the new policy restricts providers and clinics that receive federal Title ...
(Date:8/14/2019)... ... August 14, 2019 , ... ScribeAmerica, the nation’s most ... a place on the Inc. magazine 500/5000 list today for the ninth consecutive ... of ScribeAmerica’s recognition as one of the fastest growing companies in America. ...
(Date:8/14/2019)... ... , ... In a recent Trivedi Effect workshop, Master Dahryn Trivedi spoke about ... “Doubt can obliterate your old beliefs,” said Master Dahryn. “Doubt helps you look at ... understanding and your awareness. Trust that the Divine has put you here for a ...
(Date:8/12/2019)... ... 2019 , ... Eco Pump Services is an experienced, licensed, and ... over 25 years, Eco Pump Services has served customers with excellence and exceptional customer ... Eco Pump’s steady five-star ratings and excellent customer reactions throughout numerous online review sources ...
(Date:8/12/2019)... ... 2019 , ... Injured veterans from across the U.S. will ... annual Lockton Warfighter Sports Charity Challenge being held on September 9 at Trump ... event again this year will be fifty wounded warfighters and Craig Stadler, 1982 ...
Breaking Medicine News(10 mins):
(Date:8/17/2019)... ... August 17, 2019 , ... Inc. Magazine Unveils Its Annual ... No. 2502 on the 2019 Inc. 5000 with Three-Year Revenue Growth of 157% ... recruitment firm is No. 2502 on its annual Inc. 5000 list, the most ...
(Date:8/16/2019)... ... August 16, 2019 , ... SignatureCare Emergency Center has ... Houston, TX including Montrose, Heights, Memorial City, and Bellaire, TX. , The one-day ... Heights, is aimed at helping Houston families get their children caught up on ...
(Date:8/16/2019)... NEW YORK (PRWEB) , ... August 16, 2019 ... ... first-in-class brain aminopeptidase inhibitor (BAPAI) that could potentially treat treatment-resistant hypertension by acting ... that there are around 150 million people worldwide that are affected by treatment-resistant ...
Breaking Medicine Technology:
Cached News: