Carcinogen in cigarettes causes mutation linked to lung cancer

l. Then they observed the effects of the chemical using their mapping technique. They found that the carcinogen preferentially bound to the K-RAS gene at a mutational hot-spot called codon 12, an area especially vulnerable to mutation. Moreover, the researchers found that this site was not able to repair itself very well. The chemical did not bind significantly to other members of the RAS gene family.

Genes comprise codons, sequences of three chemicals that spell out the code for amino acids, the building blocks of proteins. The mapping technique relies in part on special enzymes that cut DNA where it has been damaged by the binding of a carcinogen, which is technically called a DNA adduct. Adducts cause mutations in codons.

Dr. Tang says that the study's findings provide further proof that smoking does cause lung cancer because the carcinogen bound most strongly to the precise site in the K-RAS gene that is frequently mutated in lung cancer. Using the same mapping technique, he says it may be possible to discover the environmental agent or agents that are causing the gene to mutate in pancreatic cancer, which is far more commonly associated with a codon 12 mutation than is lung cancer.

"If we could identify the agents that are causing the mutations, then we might be able to design effective measures to prevent this type of cancer," says Dr. Tang.

In the future, Dr. Tang hopes to identify the mechanisms that make the codon in the K-RAS gene more susceptible to damage. He also plans to explore the possibility that there may be individual differences in susceptibility to damage at this site, meaning that some people may be more prone to certain types of cancer.

In an editorial accompanying the study in the same issue of the Journal of the National Cancer Institute, researchers Michael J. Kelley and Susan J. Littman of Duke University Medical Center, Durham, NC, write: "[U]nderstanding the bio

Contact: Pam McDonnell
New York University Medical Center and School of Medicine

Page: 1 2 3

Related medicine news :

1. Cherry Hamburgers Lower In Suspected Carcinogens
2. Restaurant Meats Higher In Suspected Carcinogens
3. Tobacco-company-sponsored parties with free cigarettes may encourage students to start smoking
4. Majority of cigarettes in the US smoked by nicotine-dependent or psychiatrically ill persons
5. Activism prompts teen smokers to cut back on cigarettes, Stanford study finds
6. Heavy smokers see cigarettes as friends
7. Low tar cigarettes do not cut lung cancer risk
8. UNC study shows Internet offers youths easy way to buy cigarettes
9. Rising cost of cigarettes may help smokers honor new years resolution to quit
10. Brain chemicals can thwart desire to smoke cigarettes
11. It is easy for adolescents to purchase cigarettes illegally in North Carolina

Post Your Comments:

(Date:12/1/2015)... N.C. (PRWEB) , ... December 01, 2015 , ... The ... to drive awareness and funds for Multiple System Atrophy (MSA) research, timed today to ... Atrophy takes many things from patients including their ability to work and be productive, ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... Royal River ... a new study that found post-menopausal women who took the nutritional supplement creatine, along ... women who trained but did not take creatine. , The report is part of ...
(Date:12/1/2015)... ... December 01, 2015 , ... Baptist Medical Center Jacksonville has ... the only hospital in the region providing what is known as the world’s ... patients were revealed recently at a medical conference and published in The New ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... ... identification tests to continue the expansion of the company’s growing product line of ... for Chinook (Oncorhynchus tshawytscha) and Sockeye (Oncorhynchus nerka) – allow InstantLabs to offer ...
(Date:12/1/2015)... ... December 01, 2015 , ... Diabetic foot wounds ... Podiatrists are well aware that psychology-based patient non-compliance (disobedience of a health care ... to diseases of the diabetic foot. The American Board of Multiple Specialties ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... --> --> ... Acid Labeling Market by Product (Reagents & Kits, Services), ... Vitro Transcription, Reverse Transcription, End Labeling), by Region - ... market is expected to reach USD 1,925.7 Million by ... a CAGR of 8.65%. Browse 77 market ...
(Date:12/1/2015)... 1, 2015 Building on its 25-year ... Johnson (NYSE: JNJ ) today announced four ... to significantly reduce the burden of HIV incidence, ... percent of new HIV infections among adolescents in ... Day, these new initiatives include collaborations with the ...
(Date:12/1/2015)... DUBLIN , Dec. 01, 2015 ... ) has announced the addition of ... Testing Market: Campylobacter, Cryptosporidium, E. Coli, ... Yersinia" report to their offering. ... announced the addition of the ...
Breaking Medicine Technology:
Cached News: