HOME >> MEDICINE >> NEWS
Cedars-Sinai researchers identify a gene that causes insulin resistance in Mexican Americans

(LOS ANGELES December 29, 2003) For over a decade, scientists have known that insulin resistance a syndrome where the body does not respond as well as it should to insulin is linked to the development of heart disease, diabetes, high blood pressure, obesity and polycystic ovary syndrome. In fact, one in four adult Americans has insulin resistance, with Mexican Americans having the highest prevalence. But because people with insulin resistance are so likely to develop diseases such as diabetes and heart disease, scientists have turned their attention on investigating whether a common gene abnormality may be involved.

Now, researchers at Cedars-Sinai Medical Center, in collaboration with investigators at UCLA, have found that lipoprotein lipase (LPL), a gene that controls the delivery of fatty acids to muscle and tissues in the body, is linked to insulin resistance in Mexican-Americans. Their findings, reported in the January issue of Diabetes, may enable scientists to design therapies that target LPL to prevent insulin resistance, a condition estimated to affect over 80 percent of the 16 million Americans with Type 2 diabetes, and additional millions at risk for heart disease.

"This is the first study to definitively show that LPL is a gene for common insulin resistance," said Jerome I. Rotter, M.D., Director of the Division of Medical Genetics and Director of the Common Disease Genetics Program at Cedars-Sinai Medical Center.

In recent years, LPL has emerged as a likely "gene candidate" to study for insulin resistance because some studies had linked it to high blood pressure, obesity, and atherosclerosis (fatty deposits in the arteries) all of which are associated with the insulin resistance syndrome. But the studies were small, used limited diagnostic tests, and looked at only small portions of the LPL gene.

To determine whether LPL was directly linked to insulin resistance, researchers under Dr. Rotter's direc
'"/>

Contact: Kelli Hanley or Sandy Van
kelli.hanley@cshs.org
310-423-3674
Cedars-Sinai Medical Center
29-Dec-2003


Page: 1 2 3

Related medicine news :

1. Cedars-Sinai medical tipsheet for Dec. 2004
2. Cedars-Sinai October 2004 medical tipsheet
3. Cedars-Sinai Medical tipsheet for May 2004
4. Cedars-Sinai receives full AAHRPP accreditation for all research involving human subjects
5. Cedars-Sinai March medical tipsheet
6. Medical geneticist at Cedars-Sinai awarded $8.5 million NIH research grant
7. Cedars-Sinai researchers detail events that enable brain tumors to weaken immune system
8. Cedars-Sinai Medical tipsheet for July 2003
9. Cedars-Sinai researchers to present findings at Amerian College of Cardiology Scientific Meeting
10. Patients who need cardiac resynchronization therapy may be eligible for Cedars-Sinai clinical trials
11. Study at Cedars-Sinai Medical Center investigates effectiveness of two popular dietary supplements to improve symptoms of osteoarthritis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/20/2017)... , ... February 20, 2017 , ... ... offering a full range of emergency dental care at his office, Antoine Dental ... When patients experience dental emergencies, they are at risk for serious complications and ...
(Date:2/20/2017)... FL (PRWEB) , ... February 20, 2017 , ... ... gift from Constellation Brands to purchase a new ultrasound-enhanced thrombolysis machine, a state-of-the-art ... waves. The gift was facilitated by the Pepin Family Foundation. , “We greatly ...
(Date:2/19/2017)... ... February 19, 2017 , ... "At your fingertips" electronic access ... and the Delaware Health Information Network (DHIN) have partnered to improve connectivity of ... health information exchange, DHIN stores and shares real-time health data for more than ...
(Date:2/18/2017)... ... February 17, 2017 , ... Butler Mobility invited Ken Matthews to visit ... Butler products. Ken was impressed with the safety and reliability of the Stannah ... on his show. This endorsement by Ken Matthews can be heard on News ...
(Date:2/18/2017)... MANDEVILLE, La. (PRWEB) , ... February 18, 2017 ... ... Network released today provides the latest information and contact points to easily connect ... including home care, assisted living, and elder-care funding. It also conveys material on ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... -- Acute, Chronic and Prophylaxis GVHD The global ... of 7% from 2016-2021 and CAGR of 3% from 2021-2027. The market ... 2027. The market is estimated at $0.36bn in 2016, $0.51bn in 2021, ... How ... can exploit the future business opportunities emerging in this sector. ...
(Date:2/19/2017)... , February 18, 2017 Marapharm ... to purchase a Medical Delivery Service with the specific ... transactions between qualified patients and caregivers. The delivery service ... located in the Coachella Valley, California ... Los Angeles area to the West, population ...
(Date:2/18/2017)... Feb. 17, 2017 Research and Markets has announced ... report to their offering. ... The report provides separate comprehensive analytics for the US, Canada ... Asia-Pacific , Latin America , and ... 2015 through 2022. Also, a six-year historic analysis is provided for these ...
Breaking Medicine Technology:
Cached News: