HOME >> MEDICINE >> NEWS
Cedars-Sinai researchers identify a gene that causes insulin resistance in Mexican Americans

(LOS ANGELES December 29, 2003) For over a decade, scientists have known that insulin resistance a syndrome where the body does not respond as well as it should to insulin is linked to the development of heart disease, diabetes, high blood pressure, obesity and polycystic ovary syndrome. In fact, one in four adult Americans has insulin resistance, with Mexican Americans having the highest prevalence. But because people with insulin resistance are so likely to develop diseases such as diabetes and heart disease, scientists have turned their attention on investigating whether a common gene abnormality may be involved.

Now, researchers at Cedars-Sinai Medical Center, in collaboration with investigators at UCLA, have found that lipoprotein lipase (LPL), a gene that controls the delivery of fatty acids to muscle and tissues in the body, is linked to insulin resistance in Mexican-Americans. Their findings, reported in the January issue of Diabetes, may enable scientists to design therapies that target LPL to prevent insulin resistance, a condition estimated to affect over 80 percent of the 16 million Americans with Type 2 diabetes, and additional millions at risk for heart disease.

"This is the first study to definitively show that LPL is a gene for common insulin resistance," said Jerome I. Rotter, M.D., Director of the Division of Medical Genetics and Director of the Common Disease Genetics Program at Cedars-Sinai Medical Center.

In recent years, LPL has emerged as a likely "gene candidate" to study for insulin resistance because some studies had linked it to high blood pressure, obesity, and atherosclerosis (fatty deposits in the arteries) all of which are associated with the insulin resistance syndrome. But the studies were small, used limited diagnostic tests, and looked at only small portions of the LPL gene.

To determine whether LPL was directly linked to insulin resistance, researchers under Dr. Rotter's direc
'"/>

Contact: Kelli Hanley or Sandy Van
kelli.hanley@cshs.org
310-423-3674
Cedars-Sinai Medical Center
29-Dec-2003


Page: 1 2 3

Related medicine news :

1. Cedars-Sinai medical tipsheet for Dec. 2004
2. Cedars-Sinai October 2004 medical tipsheet
3. Cedars-Sinai Medical tipsheet for May 2004
4. Cedars-Sinai receives full AAHRPP accreditation for all research involving human subjects
5. Cedars-Sinai March medical tipsheet
6. Medical geneticist at Cedars-Sinai awarded $8.5 million NIH research grant
7. Cedars-Sinai researchers detail events that enable brain tumors to weaken immune system
8. Cedars-Sinai Medical tipsheet for July 2003
9. Cedars-Sinai researchers to present findings at Amerian College of Cardiology Scientific Meeting
10. Patients who need cardiac resynchronization therapy may be eligible for Cedars-Sinai clinical trials
11. Study at Cedars-Sinai Medical Center investigates effectiveness of two popular dietary supplements to improve symptoms of osteoarthritis

Post Your Comments:
(Date:12/17/2014)... HeartMath® Inc., recognized as one of the ... (HRV), heart coherence and the physiology of emotions, ... algorithms to chipset manufacturers and consumer electronics companies. ... offer its HRV solutions, tap into its HRV ... normative HRV databases and algorithms for developing consumer ...
(Date:12/17/2014)... Appleton, WI (PRWEB) December 17, 2014 ... Benefit Administrators and its Argus Claim Review division ... two of the most common ways savings are achieved ... administrator (TPA) attributes millions of dollars in savings to ... saved in 2013. , As explained by Tom Doney, ...
(Date:12/17/2014)... IL (PRWEB) December 17, 2014 Now ... Awards celebrate the best of the best in senior ... award is only given to communities and agencies that ... the SeniorAdvisor.com site. Of the nearly 100,000 providers currently ... award. Winners of the SeniorAdvisor.com Best of 2015 Awards ...
(Date:12/17/2014)... gas prices rose in recent years, so did motorcyclist ... times of gas increases, more people start using motorcycles ... explained. They examined data gathered between 2002 and ... motorcycle registrations in the United States and the third ... a strong association between rising gas prices and an ...
(Date:12/17/2014)... News) -- Expectant parents should leave prenatal picture-taking to ... Use of ultrasound imaging and heartbeat monitors to ... the agency warns. "Although there is a ... imaging and heartbeat monitors, prudent use of these devices ... an FDA biomedical engineer, said in an agency news ...
Breaking Medicine News(10 mins):Health News:HeartMath® Inc.’s HRV Platform Solutions Available for Licensing 2Health News:HeartMath® Inc.’s HRV Platform Solutions Available for Licensing 3Health News:Out-of-Network & Medical Necessity Reviews among Top Ways TPA Identifies Significant Medical Claim Savings 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 3Health News:When Gas Prices Go Up, So Do Motorcycle Accidents, Study Finds 2Health News:FDA Warns Against Fetal 'Keepsake' Videos 2
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/942kh3/micro_market ... "Micro Market Monitor: North American Dermatology Diagnostic Devices ... http://photos.prnewswire.com/prnh/20130307/600769 Cosmetic ... has resulted in fueling the overall demand of ... of these dermatology devices is to assist in ...
(Date:12/19/2014)... Calif., Dec. 18, 2014 Capnia, Inc. ... development of medical diagnostics based on its proprietary ... flow, today announced financial results for the third ... "Following the completion of our initial ... to maximize the recently initiated CoSense® commercial launch," ...
(Date:12/19/2014)... 2014 Since last month,s FBI shutdown of ... as the leading online black market for illegal drugs ... its offering of drugs and other illegal items.  New ... did succeed in lowering the numbers of drugs and ... markets in August. But some new sites that have ...
Breaking Medicine Technology:Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 2Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 3
Cached News: