HOME >> MEDICINE >> NEWS
'Cell death' mechanism identified, may lead to improved treatment

DENVER, CO -- The key to unlocking improved therapies for herpes simplex encephalitis may lie in identifying the specific mechanisms of virus-induced neuronal degeneration that occurs with this disease. A significant step in this discovery process has recently been made by researchers who have identified a link between apoptosis, or programmed cell death and herpes simplex encephalitis (HSE), according to a study presented April 17 at the Annual Meeting of the American Academy of Neurology.

This is the first demonstration of apoptotic neuronal death in immunocompetent patients with HSE, explains study author Roberta DeBiasi, M.D., of the University of Colorado Health Sciences Center in Denver. These apoptotic, or dying, neurons appeared to be a result of direct viral injury, rather than as a consequence of secondary inflammatory responses.

Apoptosis is a particular form of cell death. It doesnt just happen to a cell, it is actually a program the cell carries out to kill itself, in response to an environmental signal, such as viral infection. Part of the reason we dont yet have better treatments for HSE is that we dont fully understand how the brain cells die, says DeBiasi. Our study shows that apoptosis is at least one important way that brain cells die in response to HSE viral infection.

HSE is the most common severe encephalitis affecting previously normal people in North America. Twenty percent of HSE patients still die with current treatment options; 40 percent of those who survive end up with significant neurological problems.

Until recently, research of this nature has been limited largely to the study of immunocompromised patients with HIV-related neurologic disease. This study examined ten immunocompetent patients with herpes simplex encephalitis (HSE). The presence of apoptotic cells in HSE was correlated with active infection and occurred in the same distribution as tissue injury.

Apoptotic cells were also
'"/>

Contact: Cheryl Alementi
calementi@aan.com
651-695-2737
American Academy of Neurology
17-Apr-2002


Page: 1 2

Related medicine news :

1. Chemists identify immune system mechanism for methamphetamine binges
2. Mouse gene shows new mechanism behind cardiac infarction in man
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Surprise mechanism behind light-induced blindness
5. Mayo Clinic discovers one mechanism for why men and women differ in immune response
6. Scientists identify key mechanism in estrogens role in preventing bone loss
7. Lab study defines and blocks mechanism that lets brain tumors sidetrack immune response
8. Researchers define mechanism that enables stem cells to track migrating brain tumor cells
9. Bayer and Onyx announce new data on dual mechanism of action of BAY 43-9006
10. Genetic switch proves two mechanisms exist by which immune system cells differentiate
11. Disrupting two cell mechanisms in combination can suppress aggressive breast cancer in mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2017)... CITY, UTAH (PRWEB) , ... April 28, 2017 ... ... as Account Manager for the North East region. Côté has 20+ years of ... consulting. Prior to Phytomer, Côté worked with an array of high-end cosmetic brands, ...
(Date:4/28/2017)... , ... April 28, 2017 , ... ... and advanced nutraceutical supplements, through its Nova Skin Sciences division, recently announced ... benefits of a moisturizer with the power of an anti-aging concentrate. ...
(Date:4/28/2017)... ... 28, 2017 , ... Rob Lowe is a popular actor that has been ... to an educational purpose as the host of the “Informed” series. The program focuses ... recent episode, the series focuses on thyroid cancer. , Although thyroid cancer is an ...
(Date:4/28/2017)... ... 2017 , ... Christie Medical Holdings, Inc. , with its market-leading ... Medical Inc. , a leader in infusion therapy and pain management. , Intravenous ... percent of hospital patients receiving a peripheral IV catheter as part of their treatment ...
(Date:4/27/2017)... ... April 27, 2017 , ... The Incentive ... and Recognition: A Nudge Guide," a groundbreaking analysis of how behavioral economics can ... to apply immediately to IRR programs, the report highlights proven behavioral economics approaches ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... Mass. , April 20, 2017  RXi ... developing innovative therapeutics that address significant unmet medical ... data from the Company,s consumer product development program, ... at the Society for Investigative Dermatology (SID) 76 ... to advance and promote the sciences relevant to ...
(Date:4/20/2017)... Research and Markets has announced the addition of the ... Outlook, Growth Trends, Key Players, Competitive Strategies and Forecasts, 2014 ... ... US$ 7,167.6 Mn in 2015, and is expected to reach ... 5.6% from 2016 to 2024. The global ...
(Date:4/19/2017)... 2017 Cardiology devices segment is anticipated to reach ... The Cardiology Devices segment is likely to create absolute $ ... 2018 over 2017. By the end of 2027, Cardiology Devices ... US$ 700 Mn, expanding at a CAGR of 18.4% over ... Asia Pacific reprocessed medical devices market in ...
Breaking Medicine Technology:
Cached News: