HOME >> MEDICINE >> NEWS
'Cell death' mechanism identified, may lead to improved treatment

DENVER, CO -- The key to unlocking improved therapies for herpes simplex encephalitis may lie in identifying the specific mechanisms of virus-induced neuronal degeneration that occurs with this disease. A significant step in this discovery process has recently been made by researchers who have identified a link between apoptosis, or programmed cell death and herpes simplex encephalitis (HSE), according to a study presented April 17 at the Annual Meeting of the American Academy of Neurology.

This is the first demonstration of apoptotic neuronal death in immunocompetent patients with HSE, explains study author Roberta DeBiasi, M.D., of the University of Colorado Health Sciences Center in Denver. These apoptotic, or dying, neurons appeared to be a result of direct viral injury, rather than as a consequence of secondary inflammatory responses.

Apoptosis is a particular form of cell death. It doesnt just happen to a cell, it is actually a program the cell carries out to kill itself, in response to an environmental signal, such as viral infection. Part of the reason we dont yet have better treatments for HSE is that we dont fully understand how the brain cells die, says DeBiasi. Our study shows that apoptosis is at least one important way that brain cells die in response to HSE viral infection.

HSE is the most common severe encephalitis affecting previously normal people in North America. Twenty percent of HSE patients still die with current treatment options; 40 percent of those who survive end up with significant neurological problems.

Until recently, research of this nature has been limited largely to the study of immunocompromised patients with HIV-related neurologic disease. This study examined ten immunocompetent patients with herpes simplex encephalitis (HSE). The presence of apoptotic cells in HSE was correlated with active infection and occurred in the same distribution as tissue injury.

Apoptotic cells were also
'"/>

Contact: Cheryl Alementi
calementi@aan.com
651-695-2737
American Academy of Neurology
17-Apr-2002


Page: 1 2

Related medicine news :

1. Chemists identify immune system mechanism for methamphetamine binges
2. Mouse gene shows new mechanism behind cardiac infarction in man
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Surprise mechanism behind light-induced blindness
5. Mayo Clinic discovers one mechanism for why men and women differ in immune response
6. Scientists identify key mechanism in estrogens role in preventing bone loss
7. Lab study defines and blocks mechanism that lets brain tumors sidetrack immune response
8. Researchers define mechanism that enables stem cells to track migrating brain tumor cells
9. Bayer and Onyx announce new data on dual mechanism of action of BAY 43-9006
10. Genetic switch proves two mechanisms exist by which immune system cells differentiate
11. Disrupting two cell mechanisms in combination can suppress aggressive breast cancer in mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... transport experience for the millions of people who require these medical transport services ... industry through the use of technology. Now, SmartEMS has put forth an industry-changing ...
(Date:6/26/2016)... PLAINSBORO, N.J. (PRWEB) , ... June 27, 2016 , ... ... same sources, yet in many ways they remain in the eye of the beholder, ... Oncology (EBO), a publication of The American Journal of Managed Care. For the full ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Pixel Film Studios ... X. , "Film editors can give their videos a whole new perspective by using ... - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different ...
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
Breaking Medicine Technology:
Cached News: