Cell degradation is topic of science review

Molecular biologist discusses role of autophagy

Autophagy, the process of self-digestion of cell components through the action of enzymes within a cell, plays a vital role in cell maintenance and development, but in recent years has also been linked to a growing number of human diseases, including neurodegenerative conditions, cardiovascular disease and breast cancer.

In the Dec. 1, 2000 issue of the journal Science, UCSD professor of cellular and molecular medicine and Howard Hughes Medical Institute investigator Scott D. Emr, Ph.D., reviews recent findings regarding autophagy and advances made in identifying its molecular components.

Along with co-author Daniel J. Klionsky from the University of Michigan, Emr notes that autophagy, the breakdown and recycling of cellular material, is seen in yeast, plants and animals. Although first identified more than 20 years ago, scientific interest in autophagy was fairly modest until the identification about five years ago of several of the molecular components underlying this important process. Since then, some 30 genes have been identified as part of the autophagy pathway. Within the past two years, researchers have identified a link between decreased levels of one of these genes, called beclin 1, and breast cancer.

There are many lines of evidence that connect autophagy to human disease, Emr says. Lower levels of autophagy genes have been linked to cancer and heart disease, while elevated expression of autophagy is associated with neurodegenerative diseases such as Parkinsons.

In the Science review, Emr and Klionsky note that several questions remain for researchers, including the mechanism by which cells sense the need for autophagy and the specific roles of genes within the autophagy pathway.


Contact: Sue Pondrom
University of California - San Diego

Page: 1

Related medicine news :

1. UCSD researchers determine mechanism for degradation of G proteins
2. New ways to design safer & more effective topical (transdermal) drug delivery announced in the PNAS
3. 2004s top 10 hot topics in plastic surgery
4. Media update: GSA underscores hottest meeting topics
5. Health benefits of citrus topic at American Chemical Society meeting in Philadelphia
6. Adding menthol to topical creams for osteoarthritis provides significant pain relief
7. Herbal supplements testing topic of discussion at chemistry meeting March 30
8. Experts present new research on the hot topics of aging at GSAs Annual Meeting
9. Air safety, election forecasting lead topics as operations researchers meet in Miami beach
10. Yale researchers create topical estrogen that alleviates sexual dysfunction in menopausal women and eliminates side effects of conventional estrogen
11. Cutting-edge research on nicotine and mind alertness, topical migraine treatment, nursing home under treatment, and more to be presented at conference

Post Your Comments:

(Date:11/30/2015)... ... November 30, 2015 , ... ... released information for caregivers and held two webinars on topics of ‘Medical and ... free of charge at http://www.curemeso.org/caregivers . , With a loved one's diagnosis ...
(Date:11/30/2015)... ... November 30, 2015 , ... According to research ... U.S. require dental technicians to be certified or obtain continuing education. To increase ... “What’s In Your Mouth?” campaign to inform dentists that the technicians they trust ...
(Date:11/30/2015)... ... 2015 , ... An extensive directory of chiropractors has recently ... chiropractic clinics in the US. , The team at Chiropractic-Care.net understands how important ... pain sets in. When people are experiencing back and neck pain, the task ...
(Date:11/30/2015)... ... November 30, 2015 , ... The Museum ... summer, ushering in a new era of publicly accessible automated technology. Now, by ... continue to offer guests an up-close look at the shuttle at MOSI’s main ...
(Date:11/30/2015)... Michigan (PRWEB) , ... November 30, 2015 , ... ... safe and fun atmosphere for Halloween festivities, the Word of Life Christian Church ... children’s board game, and featuring a giant 1.25 ton pile of candy dubbed ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... global cell culture market is expected ... bn by 2022 at a CAGR of 7.1% therein. --> ... its 2013 value of US$6.1 bn to US$11.3 bn by 2022 ... Research has announced the release of a new market research study, ... ,Cell Culture Market - Global Industry Analysis, Size, Share, Growth, Trends ...
(Date:11/30/2015)... and BOCA RATON, Fla. ... for the Commercialization of Public Research (the Institute) ... with KynderMed , a medical device start-up company ... supports new company creation based on publicly-funded research, and ... Florida -based universities and research institutions. ...
(Date:11/30/2015)... 30 September 2015 2014RestatedChange%Turnover 545,575 , 518,852 , 5.2 ... 384,242 , 9.8 Hospital Management Service Income , ... Medical Insurance Administration Service Income , 2,780 , ... Sales , 89,645 , 94,580 , ... , 2,917 , (3.3) Gross Profit 395,857 ...
Breaking Medicine Technology:
Cached News: