HOME >> MEDICINE >> NEWS
Cell degradation is topic of science review

Molecular biologist discusses role of autophagy

Autophagy, the process of self-digestion of cell components through the action of enzymes within a cell, plays a vital role in cell maintenance and development, but in recent years has also been linked to a growing number of human diseases, including neurodegenerative conditions, cardiovascular disease and breast cancer.

In the Dec. 1, 2000 issue of the journal Science, UCSD professor of cellular and molecular medicine and Howard Hughes Medical Institute investigator Scott D. Emr, Ph.D., reviews recent findings regarding autophagy and advances made in identifying its molecular components.

Along with co-author Daniel J. Klionsky from the University of Michigan, Emr notes that autophagy, the breakdown and recycling of cellular material, is seen in yeast, plants and animals. Although first identified more than 20 years ago, scientific interest in autophagy was fairly modest until the identification about five years ago of several of the molecular components underlying this important process. Since then, some 30 genes have been identified as part of the autophagy pathway. Within the past two years, researchers have identified a link between decreased levels of one of these genes, called beclin 1, and breast cancer.

There are many lines of evidence that connect autophagy to human disease, Emr says. Lower levels of autophagy genes have been linked to cancer and heart disease, while elevated expression of autophagy is associated with neurodegenerative diseases such as Parkinsons.

In the Science review, Emr and Klionsky note that several questions remain for researchers, including the mechanism by which cells sense the need for autophagy and the specific roles of genes within the autophagy pathway.


'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
30-Nov-2000


Page: 1

Related medicine news :

1. UCSD researchers determine mechanism for degradation of G proteins
2. New ways to design safer & more effective topical (transdermal) drug delivery announced in the PNAS
3. 2004s top 10 hot topics in plastic surgery
4. Media update: GSA underscores hottest meeting topics
5. Health benefits of citrus topic at American Chemical Society meeting in Philadelphia
6. Adding menthol to topical creams for osteoarthritis provides significant pain relief
7. Herbal supplements testing topic of discussion at chemistry meeting March 30
8. Experts present new research on the hot topics of aging at GSAs Annual Meeting
9. Air safety, election forecasting lead topics as operations researchers meet in Miami beach
10. Yale researchers create topical estrogen that alleviates sexual dysfunction in menopausal women and eliminates side effects of conventional estrogen
11. Cutting-edge research on nicotine and mind alertness, topical migraine treatment, nursing home under treatment, and more to be presented at conference

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cell degradation topic science review

(Date:10/22/2014)... Texas (PRWEB) October 22, 2014 ... of completing their continuing education at home or ... have access to 20 brand new, premium Seminar-on-Demand ... robust catalog of over 2,000 hours ... fully customize their educational experience. With such a ...
(Date:10/22/2014)... 2014 Richard Carlson, Managing Partner of ... with over 25 years experience. Mr. Carlson is ... areas related to EDI, B2B Commerce, RFID and Internet/Intranet ... Advisory Board member for Pharmaceutical Commerce Magazine and a ... Group is a management and technology consulting firm focused ...
(Date:10/22/2014)... 2014 (HealthDay News) -- Two sisters in high school ... Ilina and Medha Krishen use electronic stethoscopes, which ... trouble in breathing patterns or heartbeats. Ilina, a ... wanted to find a way to detect early lung ... an electronic stethoscope, Ilina recorded one breath cycle each ...
(Date:10/22/2014)... Dennis Thompson HealthDay ... U.S. health officials on Monday officially tightened guidelines for health ... no skin exposure and use of a respirator at all ... decided to issue the tougher rules after two Dallas nurses ... in the United States, Liberian national Thomas Eric Duncan. Nina ...
(Date:10/20/2014)... 2014 Allegheny General Hospital’s (AGH) Cardiovascular ... physicians to repair a damaged mitral valve as the ... system, developed by Abbott Vascular , is designed ... life-threatening condition in which the heart’s mitral valve leaflets ... from the heart’s left ventricle into the left atrium. ...
Breaking Medicine News(10 mins):Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3
(Date:10/22/2014)... HOUSTON , Oct. 22, 2014  Charlene Vernak, RPh, ... York , recently was awarded the George Roentsch ... Vernak received the award in Houston ... The scholarship is awarded annually to an independent pharmacist ... nature of George Roentsch , a well-known pharmacist ...
(Date:10/22/2014)... A new report by Allied ... Form, End user, Application and Geography) - Size, Share, ... Opportunities, Segmentation and Forecast, 2013 - 2020", considers commercial ... key trends tracked, it is anticipated that the market ... 2020, registering a CAGR of 6.2% from 2014 to ...
(Date:10/22/2014)... LOUIS , Oct. 21, 2014  Early ... often subtle or unnoticed, but new technology, coupled ... outcomes and leading to earlier detection of eye ... affects 29 million Americans. If left untreated, these ... even blindness. Recently, optometric researchers ...
Breaking Medicine Technology:PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 2Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 3
Cached News: