HOME >> MEDICINE >> NEWS
Cervical cancer vaccine may lose effectiveness during ovulation

A new study has found that a vaccine against human papillomavirus 16 (HPV16), the virus that causes cervical cancer, produces antibodies against HPV16 at the site where cervical cancer develops--a promising indication of the vaccine's effectiveness. However, antibody levels appear to decrease around ovulation, raising the possibility that the vaccine may be less effective during that time. The findings appear in the August 6 issue of the Journal of the National Cancer Institute.

A vaccine is considered promising if it can produce an immune response (determined by levels of antibodies) at disease-specific sites such as the cervix. Past studies have shown that an HPV16 vaccine can trigger an immune response and protect against HPV16 infection. However, most of these studies involved women who were taking oral contraceptives (which regulate menstruation), and it is unclear what effect changes in hormone levels during the natural menstrual cycle would have on the vaccine's effectiveness.

To examine the influence of menstrual cycle stage and oral contraceptive use on antibody levels, Denise Nardelli-Haefliger, Ph.D., of the Centre Hospitalier Universitaire Vaudois in Lausanne, Switzerland, and Douglas R. Lowy, M.D., of the National Cancer Institute, and their colleagues administered the HPV 16 vaccine to seven women who were taking oral contraceptives and 11 women who were ovulating. The researchers collected blood and cervical secretions twice a week for 5 weeks and determined concentrations of anti-HPV16 antibodies during different phases of the menstrual cycle.

All of the women had relatively high levels of antibodies in their cervical secretions after immunization. Among women taking oral contraceptives, antibody levels remained relatively constant throughout the menstrual cycle. In contrast, levels of vaccine-specific and total antibodies in ovulating women were highest during the proliferative phase of the menstrual cycle and lowes
'"/>

Contact: Linda Wang
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
5-Aug-2003


Page: 1 2

Related medicine news :

1. Cervical cancer treatment depends on patient age
2. Cervical cancer A single vaccine could benefit most women
3. Cervical tissue changes may explain false negative pap smears
4. Further Evidence On The Effect Of The UK Cervical Screening Programme
5. Cervical Screening Has Reduced Incidence And Mortality From Cervical Cancer
6. Vinegar Offers Dependable Test For Cervical Cancer
7. Women Who Have Invasive Cervical Cancer Benefit From Addition Of Chemotherapy To Radiation Treatment
8. Hormonal treatment improves survival in high-risk prostate cancer patients
9. International breast cancer prevention study launches in the United States and Canada
10. Unexpected benefit seen in treating HER-2 breast cancer with new preoperative drug combo
11. Cultural and social factors influence prostate cancer treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/2/2018)... (PRWEB) , ... August 02, 2018 , ... Dr. ... psychology and brain biology of why some people could care less, demonstrating a “whatever” ... While there are many reasons for this, one often overlooked reason relates to being ...
(Date:8/2/2018)... ... August 02, 2018 , ... ... recruit caregivers to participate in brain cancer caregiver and patient clinical trials at ... Health Services of Southern California. , At the Pacific Neuroscience Institute ...
(Date:8/2/2018)... (PRWEB) , ... August 02, ... ... national medical claims management solutions provider, announced today that it has acquired ... evaluations (IMEs), medical record reviews, peer reviews, and related services. , Medlogix ...
(Date:8/2/2018)... (PRWEB) , ... August 02, 2018 , ... Josh Sprague, ... hydration products for high-intensity athletes, recently sat down with SGB Media to discuss his ... a simple philosophy. His goal was to create better, more efficient gear to help ...
(Date:8/1/2018)... ... August 01, 2018 , ... Matt ... and Vice President, Addiction Treatment Services, Behavioral Health Division of Universal ... Services business of Universal Health Services, which includes the FRN portfolio comprised of ...
Breaking Medicine News(10 mins):
(Date:8/2/2018)... ... ... What: The Wharton School is pleased to invite business journalists to apply ... who cover aspects of public policy to attend the Wharton Seminars for Business ... cost of tuition, course materials, most group meals, lodging for three nights and airfare ...
(Date:8/2/2018)... ... August 02, 2018 , ... Periodontist, Dr. Andres Sanchez, welcomes ... lengthening treatment at his Eden Prairie, MN practice. Aesthetic crown lengthening or ... decades of experience, Dr. Sanchez is excited to welcome new patients for a ...
(Date:8/2/2018)... ... August 02, 2018 , ... Clay and Associates DDS, PLC is excited ... Wallingford will join Dr. John Clay and Dr. Shaun O’Neill as an associate dentist ... for all of their patients' dental hygiene, encapsulates the core values of the professional ...
Breaking Medicine Technology:
Cached News: