HOME >> MEDICINE >> NEWS
Cervical cancer vaccine may lose effectiveness during ovulation

A new study has found that a vaccine against human papillomavirus 16 (HPV16), the virus that causes cervical cancer, produces antibodies against HPV16 at the site where cervical cancer develops--a promising indication of the vaccine's effectiveness. However, antibody levels appear to decrease around ovulation, raising the possibility that the vaccine may be less effective during that time. The findings appear in the August 6 issue of the Journal of the National Cancer Institute.

A vaccine is considered promising if it can produce an immune response (determined by levels of antibodies) at disease-specific sites such as the cervix. Past studies have shown that an HPV16 vaccine can trigger an immune response and protect against HPV16 infection. However, most of these studies involved women who were taking oral contraceptives (which regulate menstruation), and it is unclear what effect changes in hormone levels during the natural menstrual cycle would have on the vaccine's effectiveness.

To examine the influence of menstrual cycle stage and oral contraceptive use on antibody levels, Denise Nardelli-Haefliger, Ph.D., of the Centre Hospitalier Universitaire Vaudois in Lausanne, Switzerland, and Douglas R. Lowy, M.D., of the National Cancer Institute, and their colleagues administered the HPV 16 vaccine to seven women who were taking oral contraceptives and 11 women who were ovulating. The researchers collected blood and cervical secretions twice a week for 5 weeks and determined concentrations of anti-HPV16 antibodies during different phases of the menstrual cycle.

All of the women had relatively high levels of antibodies in their cervical secretions after immunization. Among women taking oral contraceptives, antibody levels remained relatively constant throughout the menstrual cycle. In contrast, levels of vaccine-specific and total antibodies in ovulating women were highest during the proliferative phase of the menstrual cycle and lowes
'"/>

Contact: Linda Wang
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
5-Aug-2003


Page: 1 2

Related medicine news :

1. Cervical cancer treatment depends on patient age
2. Cervical cancer A single vaccine could benefit most women
3. Cervical tissue changes may explain false negative pap smears
4. Further Evidence On The Effect Of The UK Cervical Screening Programme
5. Cervical Screening Has Reduced Incidence And Mortality From Cervical Cancer
6. Vinegar Offers Dependable Test For Cervical Cancer
7. Women Who Have Invasive Cervical Cancer Benefit From Addition Of Chemotherapy To Radiation Treatment
8. Hormonal treatment improves survival in high-risk prostate cancer patients
9. International breast cancer prevention study launches in the United States and Canada
10. Unexpected benefit seen in treating HER-2 breast cancer with new preoperative drug combo
11. Cultural and social factors influence prostate cancer treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... services for healthcare compliance program management, will showcase a range of technology and ... for Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed ... consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has ... highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... AccentCare, a leader in post-acute health care, have expanded their existing home health ... Home Health. , AccentCare has been operating a joint venture home health company ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare ... Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during ... , The annual award competition recognizes editorial and design excellence across a range of ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... 28, 2017 Cohen Veterans Bioscience and Early ... of wearable and home sensors for real-time monitoring of ... Foundation, a nonprofit organization focused on disruptive health solutions ... affordable analytical system to record and integrate behavioral, cognitive, ... ...
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017 /PRNewswire/ ... health and big data solutions, today announced that its MyDario product is ... your local TV listings for when The Dr. Oz Show airs in ... The nine-time ... month. ...
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., ... vaccine design, and immune-engineering today announced the launch ... the development of personalized therapeutic cancer vaccines. EpiVax ... provided exclusive access to enabling technologies to the ... MBA will lead EpiVax Oncology as Chief Executive ...
Breaking Medicine Technology:
Cached News: