HOME >> MEDICINE >> NEWS
Cervical tissue changes may explain false negative pap smears

LOS ANGELES, June 18- Some women may be getting false negative results on their routine Pap tests- the traditional method to detect cervical cancer early- because aberrant tissue changes can keep abnormal cells from being picked up during the exam, according to a study released today.

Writing in the June issue of the American Journal of Obstetrics & Gynecology, physicians at the Keck School of Medicine of USC and colleagues in California and Taiwan are the first to suggest this explanation for the frequent occurrence of false negative Pap smears.

Nationwide, physicians perform about 55 million Pap tests every year to look for cervical cells that are becoming abnormal, a precursor to cancer. To perform such a smear, a physician inserts a swab through a patient's vagina and scrapes the cervix to collect a sample of cells shed from its surface. Pathologists analyze the cells under a microscope to see if they are healthy.

Unfortunately, as many as four in 10 test results come back negative even when a biopsy shows abnormal lesions, and researchers have not been able to conclusively explain the inconsistencies.

A substance called E-cadherin may lie at the heart of the problem, says the study's lead author, Juan C. Felix, M.D., professor of clinical pathology and obstetrics and gynecology at the Keck School of Medicine of USC.

E-cadherin is a molecule that helps cells in the cervical tissue stick together, Felix explains. Normally, E-cadherin can be found in cervical tissue, except on the cervix's surface (the superficial epithelial layers). With no E-cadherin there, older cells can detach and slough away from the surface of the cervix, much like dead cells are regularly exfoliated from the surface of the skin.

However, the researchers found that in some cervical lesions, E-cadherin also was abnormally present in cells on the cervix's surface, keeping the abnormal epithelial cells anchored to the cells beneath them. Research
'"/>

Contact: Jon Weiner
Jonweine@usc.edu
323-442-2830
University of Southern California
24-Jun-2002


Page: 1 2

Related medicine news :

1. Cervical cancer treatment depends on patient age
2. Cervical cancer A single vaccine could benefit most women
3. Cervical cancer vaccine may lose effectiveness during ovulation
4. Further Evidence On The Effect Of The UK Cervical Screening Programme
5. Cervical Screening Has Reduced Incidence And Mortality From Cervical Cancer
6. Vinegar Offers Dependable Test For Cervical Cancer
7. Women Who Have Invasive Cervical Cancer Benefit From Addition Of Chemotherapy To Radiation Treatment
8. Medical molecules designed to respond to visible light that can penetrate tissue
9. Rice scientist recognized as pioneer in tissue engineering
10. How platelets help cancer invade other tissues
11. Long-term obesity linked to loss of brain tissue in women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/11/2018)... Fla. (PRWEB) , ... August 10, 2018 , ... Johns ... wellness of children in the region by utilizing a population health perspective on care. ... population by ensuring families are being treated at the right facility or setting at ...
(Date:8/9/2018)... ... August 09, 2018 , ... Thousands ... have ruptured, according to cross-referenced data from The American Society of Plastic Surgeons ... rupture rates monitored by the FDA. As an MRI is recommended by FDA ...
(Date:8/9/2018)... ... August 09, 2018 , ... ... medication adherence monitoring with Smart-pill bottle and mobile applications, DoseSmart announced today ... Orchard. , The DoseSmart medication management and medication adherence platform helps hospitals ...
(Date:8/7/2018)... Colo. (PRWEB) , ... August 07, 2018 , ... Josh ... the release of a video preview for the upcoming Leadville 100 MTB. , ... through 100 miles of what he has called “one of the most iconic mountain ...
(Date:8/7/2018)... ... August 07, 2018 , ... The American Psychiatric Nurses Association ... the 2018 Board of Directors Student Scholarship . The APNA student scholarship ... nursing and develop the next generation of leaders in the profession. , ...
Breaking Medicine News(10 mins):
(Date:8/3/2018)... ... August 03, 2018 , ... Flexefits, a pioneer in direct -pay, ... for its allowing participants in Direct Primary Care arrangements to keep HSA eligibility and ... $150 per individual and $300 per family per month.) , “We are very pleased ...
(Date:8/2/2018)... ... August 02, 2018 , ... The ... with four awards on Wednesday, July 11, 2018, recognizing the hospital’s commitment to ... their patients. , , Get With The Guidelines®-Stroke Gold ...
(Date:8/2/2018)... MN (PRWEB) , ... August 02, 2018 , ... ... MN with a gummy smile for custom crown lengthening treatment at ... an uneven gum line and an unsteady self-conscious. Using decades of experience, Dr. ...
Breaking Medicine Technology:
Cached News: