HOME >> MEDICINE >> NEWS
Cervical tissue changes may explain false negative pap smears

ers theorize that this bond keeps these telltale aberrant cells from being collected during testing.

"I am convinced that the findings of this study are extremely important in understanding the biology of the false negative Pap smear," Felix says. "Never before have we seen such clear evidence that barriers to exfoliation are linked to false negative Pap smears." The team conducted the study with tissue samples from 25 women known to have cervical dysplasia (aberrant cells preceding cancer). Researchers analyzed whether the tissue samples showed normal distribution of E-cadherin, and then compared each tissue sample to its corresponding Pap smear result.

Of the 25 women, 12 had had a normal Pap smear. All 12 of these women, however, had a positive result through speculoscopy with PapSure. PapSure is a testing system that includes a special light used during the pelvic examination, allowing physicians to actually see suspicious lesions on the cervix.

The remaining 13 women had abnormal Pap smears. Researchers were able to analyze E-cadherin distribution in 10 of these samples. Eight of 10 of these samples showed normal distribution of E-cadherin.

In contrast, of the 12 women with false negative Pap smears, 10 of 11 samples that could be examined showed the abnormal presence of E-cadherin in the superficial layers of the cervix.

"Of the patients with known cervical abnormalities who had normal Pap smears, 91 percent had an abnormal distribution of the E-cadherin adhesion molecule," Felix says. Felix cautions, however, that larger studies with randomly selected patients are needed to verify the findings. Other adhesion molecules also may be involved in the process.

Possible alternative reasons for false-negative Pap smears include poor cell sample collection, mistakes in transferring cells to slides and human error in evaluating the collected cells.


'"/>

Contact: Jon Weiner
Jonweine@usc.edu
323-442-2830
University of Southern California
24-Jun-2002


Page: 1 2

Related medicine news :

1. Cervical cancer treatment depends on patient age
2. Cervical cancer A single vaccine could benefit most women
3. Cervical cancer vaccine may lose effectiveness during ovulation
4. Further Evidence On The Effect Of The UK Cervical Screening Programme
5. Cervical Screening Has Reduced Incidence And Mortality From Cervical Cancer
6. Vinegar Offers Dependable Test For Cervical Cancer
7. Women Who Have Invasive Cervical Cancer Benefit From Addition Of Chemotherapy To Radiation Treatment
8. Medical molecules designed to respond to visible light that can penetrate tissue
9. Rice scientist recognized as pioneer in tissue engineering
10. How platelets help cancer invade other tissues
11. Long-term obesity linked to loss of brain tissue in women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Global Healthcare ... scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare ... activity. The fun run is geared towards children of all ages; it is ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... DevOps and Agile Software Development, has been awarded a contract by the Center ... Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed a ... and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been ... standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized health ... expanded their existing home health joint venture through an agreement, effective October 1, ... joint venture home health company with Asante, delivering clinically integrated care, for the ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Texas , Oct. 11, 2017  Caris Life ... focused on fulfilling the promise of precision medicine, today ... has joined Caris, Precision Oncology Alliance™ (POA) as its ... cancer centers, the St. Jude Crosson Cancer Institute will ... advance the use of tumor profiling, making cancer treatment ...
(Date:10/10/2017)... --  West Pharmaceutical Services, Inc. (NYSE: WST), a ... today shared the results of a study highlighting the ... administration of polio vaccines. The study results were presented ... by Dr. Ondrej Mach , Clinical Trials and ... and recently published in the journal Vaccine. i ...
(Date:10/4/2017)... -- According to the Centers for Disease Control and Prevention (CDC), influenza ... Care is helping communities across Massachusetts , ... no-cost* flu shots through the end of the month. *Some ... ... flu shot is by the end of October, according to the Centers ...
Breaking Medicine Technology:
Cached News: